{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:16:31Z","timestamp":1792588591824,"version":"4.5.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chikungunya virus (CHIKV) is an alphavirus that causes chronic and incapacitating arthralgia in humans. Injury to the joint is believed to occur because of viral and host immune-mediated effects. However, the exact involvement of the different immune mediators in CHIKV-induced pathogenesis is unknown. In this study, we assessed the roles of T cells in primary CHIKV infection, virus replication and dissemination, and virus persistence, as well as in the mediation of disease severity in adult RAG2\u2212\/\u2212, CD4\u2212\/\u2212, CD8\u2212\/\u2212, and wild-type CHIKV C57BL\/6J mice and in wild-type mice depleted of CD4+ or CD8+ T cells after Ab treatment. CHIKV-specific T cells in the spleen and footpad were investigated using IFN-\u03b3 ELISPOT. Interestingly, our results indicated that CHIKV-specific CD4+, but not CD8+, T cells are essential for the development of joint swelling without any effect on virus replication and dissemination. Infection in IFN-\u03b3\u2212\/\u2212 mice demonstrated that pathogenic CD4+ T cells do not mediate inflammation via an IFN-\u03b3\u2013mediated pathway. Taken together, these observations strongly indicate that mechanisms of joint pathology induced by CHIKV in mice resemble those in humans and differ from infections caused by other arthritogenic viruses, such as Ross River virus.<\/jats:p>","DOI":"10.4049\/jimmunol.1202177","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T10:40:21Z","timestamp":1354617621000},"page":"259-269","source":"Crossref","is-referenced-by-count":233,"title":["A Pathogenic Role for CD4+ T Cells during Chikungunya Virus Infection in Mice"],"prefix":"10.1093","volume":"190","author":[{"given":"Teck-Hui","family":"Teo","sequence":"first","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis , Singapore 138648"},{"name":"National University of Singapore Graduate School for Integrative Sciences and Engineering, National University of Singapore , Singapore 117456"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fok-Moon","family":"Lum","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis , Singapore 138648"},{"name":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore , Singapore 117597"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Claser","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis , Singapore 138648"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Lulla","sequence":"additional","affiliation":[{"name":"Institute of Technology, University of Tartu , 50411 Tartu,","place":["Estonia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksei","family":"Lulla","sequence":"additional","affiliation":[{"name":"Institute of Technology, University of Tartu , 50411 Tartu,","place":["Estonia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Merits","sequence":"additional","affiliation":[{"name":"Institute of Technology, University of Tartu , 50411 Tartu,","place":["Estonia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"R\u00e9nia","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis , Singapore 138648"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa F P","family":"Ng","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis , Singapore 138648"},{"name":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore , Singapore 117597"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"2025032406214051200_r1","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1099\/vir.0.82858-0","article-title":"Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus","volume":"88","author":"Powers","year":"2007","journal-title":"J. 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