{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:34:15Z","timestamp":1789594455582,"version":"build-2803163510"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Systemic lupus erythematosus is considered to be under the control of polygenic inheritance, developing according to the cumulative effects of susceptibility genes with polymorphic alleles; however, the mechanisms underlying the roles of polygenes based on functional and pathological genomics remain uncharacterized. In this study, we substantiate that a CD72 polymorphism in the membrane-distal extracellular domain impacts on both the development of glomerulonephritis and vasculitis in a lupus model strain of mice, MRL\/MpJ-Faslpr, and the reactivity of BCR signal stimulation. We generated mice carrying a bacterial artificial chromosome transgene originating from C57BL\/6 (B6) mice that contains the Cd72b locus (Cd72B6 transgenic [tg]) or the modified Cd72b locus with an MRL-derived Cd72c allele at the polymorphic region corresponding to the membrane-distal extracellular domain (Cd72B6\/MRL tg). Cd72B6 tg mice, but not Cd72B6\/MRL tg mice, showed a significant reduction in mortality following a marked improvement of disease associated with decreased serum levels of IgG3 and anti-dsDNA Abs. The number of splenic CD4\u2212CD8\u2212 T cells in Cd72B6 tg mice was decreased significantly in association with a reduced response to B cell receptor signaling. These results indicate that the Cd72 polymorphism affects susceptibility to lupus phenotypes and that novel functional rescue by a bacterial artificial chromosome transgenesis is an efficient approach with wide applications for conducting a genomic analysis of polygene diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1202196","type":"journal-article","created":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T03:55:32Z","timestamp":1359604532000},"page":"2129-2137","source":"Crossref","is-referenced-by-count":10,"title":["A Bacterial Artificial Chromosome Transgene with Polymorphic <i>Cd72<\/i> Inhibits the Development of Glomerulonephritis and Vasculitis in MRL-<i>Faslpr<\/i> Lupus Mice"],"prefix":"10.1093","volume":"190","author":[{"given":"Hisashi","family":"Oishi","sequence":"first","affiliation":[{"name":"Department of Anatomy and Embryology, Graduate School of Comprehensive Human Sciences, University of Tsukuba , Tsukuba 305-8575,","place":["Japan"]},{"name":"Department of Pathogenomics, Ehime University Graduate School of Medicine , Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Tsubaki","sequence":"additional","affiliation":[{"name":"Department of Pathogenomics, Ehime University Graduate School of Medicine , Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiko","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Pathogenomics, Ehime University Graduate School of Medicine , Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Tohoku University Graduate School of Medicine , Sendai 980-8575,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Nose","sequence":"additional","affiliation":[{"name":"Department of Pathogenomics, Ehime University Graduate School of Medicine , Ehime 791-0295,","place":["Japan"]},{"name":"Department of Histopathology, Tohoku University Graduate School of Medicine , Sendai 980-8575,","place":["Japan"]},{"name":"Proteo-Medicine Research Center, Ehime University , Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Graduate School of Comprehensive Human Sciences, University of Tsukuba , Tsukuba 305-8575,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"2025032406393674800_r1","first-page":"911","volume-title":"Arthritis and Allied Conditions.","author":"Rothfield","year":"1985"},{"key":"2025032406393674800_r2","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1126\/science.1076641","article-title":"Finding genes that underlie complex traits","volume":"298","author":"Glazier","year":"2002","journal-title":"Science"},{"key":"2025032406393674800_r3"},{"key":"2025032406393674800_r4","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1084\/jem.148.5.1198","article-title":"Spontaneous murine lupus-like syndromes. 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