{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:03:28Z","timestamp":1790737408680,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Annexin A1 (AnxA1) is recognized as an endogenous anti-inflammatory molecule. However, its effects on the adaptive immune response and, in particular, on T cells remain unclear. In this study, we investigated the actions of AnxA1 in three distinct models of T cell\u2013mediated inflammation. In contact hypersensitivity, collagen-induced arthritis, and inflammation induced by OT-II TCR transgenic T cells responding to OVA, AnxA1 deficiency significantly increased Ag-induced T cell proliferation and the resultant level of inflammation. In the contact hypersensitivity model, this was associated with increased adhesion of CD4+ T cells, CD8+ T cells, and neutrophils in the dermal microvasculature, as well as increased T cell expression of ROR\u03b3t and IL-17A. In collagen-induced arthritis, deficiency of endogenous AnxA1 increased susceptibility to arthritis and Ag-specific T cell activation. Deficiency of AnxA1 also increased OVA-induced cutaneous delayed-type hypersensitivity and IFN-\u03b3 and IL-17 release. Transfer experiments using CD4+ T cells from AnxA1\u2212\/\u2212 mice demonstrated that the absence of AnxA1 solely in T cells resulted in increased inflammatory responses in wild-type recipients. Similarly, experiments using AnxA1\u2212\/\u2212 OT-II CD4+ T cells demonstrated that the absence of AnxA1 in T cells was sufficient to induce increased Ag-specific CD4+ T cell proliferation in vivo, augment T cell production of IFN-\u03b3, IL-17, TNF, and IL-6, and increase Akt, ERK, and p38 activation. Together, these findings indicate that T cell\u2013expressed AnxA1 functions to attenuate T cell\u2013driven inflammatory responses via T cell\u2013intrinsic effects on intracellular signaling, proliferation, and Th1\/Th17 cytokine release.<\/jats:p>","DOI":"10.4049\/jimmunol.1202236","type":"journal-article","created":{"date-parts":[[2012,12,25]],"date-time":"2012-12-25T04:02:26Z","timestamp":1356408146000},"page":"997-1007","source":"Crossref","is-referenced-by-count":66,"title":["Deficiency of Annexin A1 in CD4+ T Cells Exacerbates T Cell\u2013Dependent Inflammation"],"prefix":"10.1093","volume":"190","author":[{"given":"Yuan H","family":"Yang","sequence":"first","affiliation":[{"name":"Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Monash University Faculty of Medicine, Nursing and Health Sciences, Monash Medical Centre , Clayton, Victoria 3168,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuqi","family":"Song","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Monash University Faculty of Medicine, Nursing and Health Sciences, Monash Medical Centre , Clayton, Victoria 3168,","place":["Australia"]},{"name":"Department of Microbiology, The Heilongjiang Key Laboratory of Immunity and Infection, Pathogenic Biology, Harbin Medical University , Harbin 150081,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A","family":"Deane","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Monash University Faculty of Medicine, Nursing and Health Sciences, Monash Medical Centre , Clayton, Victoria 3168,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenping","family":"Kao","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Monash University Faculty of Medicine, Nursing and Health Sciences, Monash Medical Centre , Clayton, Victoria 3168,","place":["Australia"]},{"name":"Department of Microbiology, The Heilongjiang Key Laboratory of Immunity and Infection, Pathogenic Biology, Harbin Medical University , Harbin 150081,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D","family":"Ooi","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Monash University Faculty of Medicine, Nursing and Health Sciences, Monash Medical Centre , Clayton, Victoria 3168,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi","family":"Ngo","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Monash University Faculty of Medicine, Nursing and Health Sciences, Monash Medical Centre , Clayton, Victoria 3168,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Richard","family":"Kitching","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Monash University Faculty of Medicine, Nursing and Health Sciences, Monash Medical Centre , Clayton, Victoria 3168,","place":["Australia"]},{"name":"Department of Nephrology, Monash Medical Centre , Clayton, Victoria 3168,","place":["Australia"]},{"name":"Department of Pediatric Nephrology, Monash Medical Centre , Clayton, Victoria 3168,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric F","family":"Morand","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Monash University Faculty of Medicine, Nursing and Health Sciences, Monash Medical Centre , Clayton, Victoria 3168,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Hickey","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Monash University Faculty of Medicine, Nursing and Health Sciences, Monash Medical Centre , Clayton, Victoria 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Neuroimmunol."},{"key":"2025032406300791800_r16","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1046\/j.1365-2222.2001.01137.x","article-title":"An annexin 1 (ANXA1)-derived peptide inhibits prototype antigen-driven human T cell Th1 and Th2 responses in vitro","volume":"31","author":"Kamal","year":"2001","journal-title":"Clin. Exp. Allergy"},{"key":"2025032406300791800_r17","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1182\/blood-2006-05-022798","article-title":"Annexin-1 modulates T-cell activation and differentiation","volume":"109","author":"D\u2019Acquisto","year":"2007","journal-title":"Blood"},{"key":"2025032406300791800_r18","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1002\/eji.200636792","article-title":"Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells","volume":"37","author":"D\u2019Acquisto","year":"2007","journal-title":"Eur. J. 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Immunol."},{"key":"2025032406300791800_r29","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1681\/ASN.2007030392","article-title":"T-bet deficiency attenuates renal injury in experimental crescentic glomerulonephritis","volume":"19","author":"Phoon","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"2025032406300791800_r30","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1681\/ASN.2010040435","article-title":"The Th17-defining transcription factor ROR\u03b3t promotes glomerulonephritis","volume":"22","author":"Steinmetz","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"2025032406300791800_r31","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1681\/ASN.2011020182","article-title":"Mast cells mediate acute kidney injury through the production of TNF","volume":"22","author":"Summers","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"2025032406300791800_r32","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/art.27330","article-title":"Endogenous estrogen regulation of inflammatory arthritis and cytokine expression in male mice, predominantly via estrogen receptor alpha","volume":"62","author":"Yang","year":"2010","journal-title":"Arthritis Rheum."},{"key":"2025032406300791800_r33","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1681\/ASN.2008080891","article-title":"IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen","volume":"20","author":"Ooi","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"2025032406300791800_r34","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1189\/jlb.0607353","article-title":"The cytoplasmic domain of tissue factor in macrophages augments cutaneous delayed-type hypersensitivity","volume":"83","author":"Apostolopoulos","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"2025032406300791800_r35","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1681\/ASN.2007030386","article-title":"Intrarenal antigens activate CD4+ cells via co-stimulatory signals from dendritic cells","volume":"19","author":"Edgtton","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"2025032406300791800_r36","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1002\/art.20580","article-title":"Expression of mitogen-activated protein kinase phosphatase 1, a negative regulator of the mitogen-activated protein kinases, in rheumatoid arthritis: up-regulation by interleukin-1beta and glucocorticoids","volume":"50","author":"Toh","year":"2004","journal-title":"Arthritis Rheum."},{"key":"2025032406300791800_r37","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.4049\/jimmunol.159.5.2484","article-title":"Repeated elicitation of contact hypersensitivity induces a shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profile","volume":"159","author":"Kitagaki","year":"1997","journal-title":"J. Immunol."},{"key":"2025032406300791800_r38","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1189\/jlb.0405206","article-title":"Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro","volume":"78","author":"Chatterjee","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"2025032406300791800_r39","doi-asserted-by":"crossref","first-page":"510","DOI":"10.4049\/jimmunol.180.1.510","article-title":"Multichannel fluorescence spinning disk microscopy reveals early endogenous CD4 T cell recruitment in contact sensitivity via complement","volume":"180","author":"Norman","year":"2008","journal-title":"J. Immunol."},{"key":"2025032406300791800_r40","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000078765","article-title":"T lymphocyte-mediated immune responses to chemical haptens and metal ions: implications for allergic and autoimmune disease","volume":"134","author":"Martin","year":"2004","journal-title":"Int. Arch. Allergy Immunol."},{"key":"2025032406300791800_r41","first-page":"131","article-title":"The role of CD4+ and CD8+ T cells in contact hypersensitivity and allergic contact dermatitis","volume":"14","author":"Saint-Mezard","year":"2004","journal-title":"Eur. J. Dermatol."},{"key":"2025032406300791800_r42","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.4049\/jimmunol.158.11.5507","article-title":"Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice","volume":"158","author":"Vermeire","year":"1997","journal-title":"J. Immunol."},{"key":"2025032406300791800_r43","doi-asserted-by":"crossref","first-page":"6173","DOI":"10.4049\/jimmunol.171.11.6173","article-title":"Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice","volume":"171","author":"Nakae","year":"2003","journal-title":"J. Immunol."},{"key":"2025032406300791800_r44","first-page":"1154","article-title":"T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice","volume":"118","author":"Jarmin","year":"2008","journal-title":"J. Clin. Invest."},{"key":"2025032406300791800_r45","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.4049\/jimmunol.0903177","article-title":"The p110 delta isoform of phosphatidylinositol 3-kinase controls the quality of secondary anti-Leishmania immunity by regulating expansion and effector function of memory T cell subsets","volume":"184","author":"Liu","year":"2010","journal-title":"J. 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Immunol."},{"key":"2025032406300791800_r48","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1084\/jem.191.6.995","article-title":"Signal transducer and activator of transcription 6 is essential in the induction of contact hypersensitivity","volume":"191","author":"Yokozeki","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025032406300791800_r49","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S1074-7613(02)00391-6","article-title":"Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses","volume":"17","author":"Nakae","year":"2002","journal-title":"Immunity"},{"key":"2025032406300791800_r50","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2332\/allergolint.R-07-160","article-title":"Th17 and allergy","volume":"57","author":"Oboki","year":"2008","journal-title":"Allergol. 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Immunol."},{"key":"2025032406300791800_r54","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1523-1747.2000.00041.x","article-title":"Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes","volume":"115","author":"Albanesi","year":"2000","journal-title":"J. Invest. Dermatol."},{"key":"2025032406300791800_r55","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4049\/jimmunol.177.1.566","article-title":"IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis","volume":"177","author":"Komiyama","year":"2006","journal-title":"J. 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