{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:55:15Z","timestamp":1778576115451,"version":"3.51.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We have previously shown that regulatory T (Treg) cells that accumulate in the airways of allergic mice upregulate CC-chemokine receptor 4 (CCR4) expression. These Treg cells suppressed in vitro Th2 cell proliferation but not type 2 cytokine production. In the current study, using a well-established murine model of allergic lung disease or oral tolerance, we evaluated the in vivo activity of Treg cells in allergic airway inflammation with special focus on CCR4 function. We found that allergic, but not tolerant, mice treated with anti-CD25 Ab showed increased airway eosinophilia and IL-5\u2013 or IL-4\u2013producing Th2 cells when compared with untreated mice. Notably, mice with CCR4 deficiency displayed an augmented airway allergic inflammation compared with wild-type or CCR2 knockout (KO) mice. The allergic phenotype of CCR4KO mice was similar to that observed in anti-CD25\u2013treated mice. The exacerbated allergic inflammation of CCR4KO mice was directly associated with an impaired migration of Treg cells to airways and augmented frequency of pulmonary Th2 cells. Adoptive transfer of CD25+CD4+ T cells expressing high levels of CCR4, but not CCR4KO CD25+CD4+ T cells, attenuated the severe airway Th2 response of CCR4KO mice. Our results show that CCR4 is critically involved in the migration of Treg cells to allergic lungs that, in turn, attenuate airway Th2 activation and allergic eosinophilic inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.1202354","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T07:22:05Z","timestamp":1360221725000},"page":"2614-2621","source":"Crossref","is-referenced-by-count":65,"title":["Regulatory T Cells Migrate to Airways via CCR4 and Attenuate the Severity of Airway Allergic Inflammation"],"prefix":"10.1093","volume":"190","author":[{"given":"Lucas","family":"Faustino","sequence":"first","affiliation":[{"name":"Department of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo , Sao Paulo, SP 05508-900,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise Morais","family":"da Fonseca","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of S\u00e3o Paulo , Ribeirao Preto, SP 14049-900,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maisa Carla","family":"Takenaka","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, S\u00e3o Paulo School of Medicine, Federal University of S\u00e3o Paulo , S\u00e3o Paulo, SP 04023-062,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Mirotti","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo , Sao Paulo, SP 05508-900,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther Borges","family":"Florsheim","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo , Sao Paulo, SP 05508-900,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia Grando","family":"Guereschi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, S\u00e3o Paulo School of Medicine, Federal University of S\u00e3o Paulo , S\u00e3o Paulo, SP 04023-062,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Santana","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of S\u00e3o Paulo , Ribeirao Preto, SP 14049-900,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Salgado","family":"Basso","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, S\u00e3o Paulo School of Medicine, Federal University of S\u00e3o Paulo , S\u00e3o Paulo, SP 04023-062,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momtchilo","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo , Sao Paulo, SP 05508-900,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"key":"2025032406414953600_r1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1172\/JCI0213696","article-title":"Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology","volume":"109","author":"Temann","year":"2002","journal-title":"J. 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Immunol."},{"key":"2025032406414953600_r38","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1067\/mai.2001.112601","article-title":"CCR4 memory CD4+ T lymphocytes are increased in peripheral blood and lesional skin from patients with atopic dermatitis","volume":"107","author":"Nakatani","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025032406414953600_r39","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/intimm\/dxf109","article-title":"Preferential expression of T(h)2-type chemokine and its receptor in atopic dermatitis","volume":"14","author":"Uchida","year":"2002","journal-title":"Int. Immunol."},{"key":"2025032406414953600_r40","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1034\/j.1398-9995.2003.00149.x","article-title":"Accumulation of CCR4-expressing CD4+ T cells and high concentration of its ligands (TARC and MDC) in bronchoalveolar lavage fluid of patients with eosinophilic pneumonia","volume":"58","author":"Katoh","year":"2003","journal-title":"Allergy"},{"key":"2025032406414953600_r41","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jaci.2004.11.049","article-title":"Pulmonary chemokines and their receptors differentiate children with asthma and chronic cough","volume":"115","author":"Hartl","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025032406414953600_r42","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev.immunol.26.021607.090312","article-title":"T cell trafficking in allergic asthma: the ins and outs","volume":"26","author":"Medoff","year":"2008","journal-title":"Annu. Rev. Immunol."},{"key":"2025032406414953600_r43","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/ni.f.213","article-title":"Orchestrating the orchestrators: chemokines in control of T cell traffic","volume":"9","author":"Bromley","year":"2008","journal-title":"Nat. Immunol."},{"key":"2025032406414953600_r44","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.jaci.2005.03.052","article-title":"IL-4-expressing bronchoalveolar T cells from asthmatic and healthy subjects preferentially express CCR 3 and CCR 4","volume":"116","author":"Morgan","year":"2005","journal-title":"J. Allergy Clin. 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