{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:44:25Z","timestamp":1790253865178,"version":"4.1.0"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients who survive severe sepsis often display compromised immune function with impairment in innate and adaptive immune responses. These septic patients are highly susceptible to \u201csecondary\u201d infections with intracellular pathogens that are usually controlled by CD8+ T cells. It is not known when and if this observed immunoparalysis of CD8+ T cell immunity recovers, and the long-term consequences of sepsis on the ability of naive CD8+ T cells to respond to subsequent infections are poorly understood. In this study, using the cecal-ligation and puncture mouse model of sepsis, we show that sepsis induces a rapid loss of naive CD8+ T cells. However, IL-15\u2013dependent numerical recovery is observed a month after initial septic insult. Numerical recovery is accompanied by IL-15\u2013dependent phenotypic changes where a substantial proportion of naive (Ag-inexperienced) CD8+ T cells display a \u201cmemory-like\u201d phenotype (CD44hi\/CD11ahi). Importantly, the impairment of naive CD8+ T cells to respond to viral and bacterial infection was sustained for month(s) after sepsis induction. Incomplete recovery of naive CD8+ T cell precursors was observed in septic mice, suggesting that the availability of naive precursors contributes to the sustained impairment in primary CD8+ T cell responses. Thus, sepsis can result in substantial and long-lasting changes in the available CD8+ T cell repertoire affecting the capacity of the host to respond to new infections.<\/jats:p>","DOI":"10.4049\/jimmunol.1202379","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T21:32:37Z","timestamp":1359149557000},"page":"1991-2000","source":"Crossref","is-referenced-by-count":87,"title":["Sustained and Incomplete Recovery of Naive CD8+ T Cell Precursors after Sepsis Contributes to Impaired CD8+ T Cell Responses to Infection"],"prefix":"10.1093","volume":"190","author":[{"given":"Stephanie A","family":"Condotta","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britnie R","family":"James","sequence":"additional","affiliation":[{"name":"Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S","family":"Griffith","sequence":"additional","affiliation":[{"name":"Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota , Minneapolis, MN 55455"},{"name":"Minneapolis Veterans Affairs Health Care System , Minneapolis, MN 55417"},{"name":"Center for Immunology, University of Minnesota , Minneapolis, MN 55455"},{"name":"Department of Urology, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir P","family":"Badovinac","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa , Iowa City, IA 52242"},{"name":"Interdisciplinary Program in Immunology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"2025032406394463600_r1","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"key":"2025032406394463600_r2","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nrd1854","article-title":"Animal models of sepsis: setting the stage","volume":"4","author":"Buras","year":"2005","journal-title":"Nat. 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