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In this study, we studied the chaperone-like activity of HMGB1 and found that HMGB1 inhibited the chemically induced aggregation of insulin and lysozyme, as well as the heat-induced aggregation of citrate synthase. HMGB1 also restored the heat-induced suppression of cytoplasmic luciferase activity as a reporter protein in hamster lung fibroblast O23 cells with expression of HMGB1. Next, we demonstrated that HMGB1 inhibited the formation of aggregates and toxicity caused by expanded polyglutamine (polyQ), one of the main causes of Huntington disease. HMGB1 directly interacted with polyQ on immunofluorescence and coimmunoprecipitation assay, whereas the overexpression of HMGB1 or exogenous administration of recombinant HMGB1 protein remarkably reduced polyQ aggregates in SHSY5Y cells and hmgb1\u2212\/\u2212 mouse embryonic fibroblasts upon filter trap and immunofluorescence assay. Finally, overexpressed HMGB1 proteins in mouse embryonic primary striatal neurons also bound to polyQ and decreased the formation of polyQ aggregates. To this end, we have demonstrated that HMGB1 exhibits chaperone-like activity and a possible therapeutic candidate in polyQ disease.<\/jats:p>","DOI":"10.4049\/jimmunol.1202472","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T16:40:55Z","timestamp":1357836055000},"page":"1797-1806","source":"Crossref","is-referenced-by-count":47,"title":["Chaperone-like Activity of High-Mobility Group Box 1 Protein and Its Role in Reducing the Formation of Polyglutamine Aggregates"],"prefix":"10.1093","volume":"190","author":[{"given":"Hyun Jin","family":"Min","sequence":"first","affiliation":[{"name":"Department of Microbiology, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]},{"name":"Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ae","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]},{"name":"Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]},{"name":"Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Kyung","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Sup","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seoul National University Boramae Hospital, Seoul National University College of Medicine , Seoul 110-799,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]},{"name":"Department of Anatomy, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeon-Soo","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]},{"name":"Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]},{"name":"Severance Biomedical Science Institute, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]},{"name":"Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine , Seoul 120-752,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,2,15]]},"reference":[{"key":"2025032406325211500_r1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1432-1033.1973.tb03026.x","article-title":"A new group of chromatin-associated proteins with a high content of acidic and basic amino acids","volume":"38","author":"Goodwin","year":"1973","journal-title":"Eur. 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