{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:27:15Z","timestamp":1787030835349,"version":"build-2736575974"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Experimental autoimmune prostatitis (EAP) is considered a valid model for the human disease chronic prostatitis\/chronic pelvic pain syndrome. In this report, we analyzed phenotypic characteristics of T cells that gain access to the prostate and induce leukocyte recruitment in mice with different susceptibility to EAP. After EAP induction, NOD mice developed a specific cellular response characterized by a mixed Th1\/Th17 pattern with specific T cells mainly expressing CXCR3 that infiltrated and damaged the prostate. In contrast, BALB\/c mice, as well as NOD-IFN-\u03b3\u2212\/\u2212, exhibited only Th17 cells mainly expressing CCR6 that were not capable of infiltrating the prostate gland. Adoptive transfer experiments of T cells from NOD or NOD\u2013IFN-\u03b3\u2212\/\u2212 mice to NOD-SCID recipients showed that only T cells from NOD mice successfully infiltrated the prostate. However, after \u201cin vitro\u201d or \u201cin vivo\u201d treatment with rIFN-\u03b3, T cells from NOD\u2013IFN-\u03b3\u2212\/\u2212 mice became capable of homing to the prostate and induced leukocyte recruitment. Chemokine levels in prostate tissue from NOD mice showed increased expression levels of CXCR3 ligands. Additional experiments using adoptive transfer of sorted CXCR3+CD3+ T cells or administrating a CXCR3 antagonist treatment confirmed these previous results. Altogether, our results demonstrate that the expression of CXCR3 on effector T cells is essential for their homing to the prostate gland in EAP. CXCR3 emerges as a potential therapeutic target to control chronic prostatitis\/chronic pelvic pain syndrome.<\/jats:p>","DOI":"10.4049\/jimmunol.1202482","type":"journal-article","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T05:23:49Z","timestamp":1362201829000},"page":"3121-3133","source":"Crossref","is-referenced-by-count":54,"title":["Expression of CXCR3 on Specific T Cells Is Essential for Homing to the Prostate Gland in an Experimental Model of Chronic Prostatitis\/Chronic Pelvic Pain Syndrome"],"prefix":"10.1093","volume":"190","author":[{"given":"Maria L","family":"Breser","sequence":"first","affiliation":[{"name":"Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba , C\u00f3rdoba, 5016","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben D","family":"Motrich","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba , C\u00f3rdoba, 5016","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo R","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba , C\u00f3rdoba, 5016","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P","family":"Mackern-Oberti","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba , C\u00f3rdoba, 5016","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia E","family":"Rivero","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba , C\u00f3rdoba, 5016","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,4,1]]},"reference":[{"key":"2025032406485889300_r1","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/S0022-5347(01)63564-X","article-title":"How common is prostatitis? A national survey of physician visits","volume":"159","author":"Collins","year":"1998","journal-title":"J. Urol."},{"key":"2025032406485889300_r2","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1056\/NEJMcp060423","article-title":"Clinical practice. Chronic prostatitis and the chronic pelvic pain syndrome","volume":"355","author":"Schaeffer","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"2025032406485889300_r3","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1001\/jama.282.3.236","article-title":"NIH consensus definition and classification of prostatitis","volume":"282","author":"Krieger","year":"1999","journal-title":"JAMA"},{"key":"2025032406485889300_r4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1615\/CritRevImmunol.v27.i1.30","article-title":"Autoimmune etiology in chronic prostatitis syndrome: an advance in the understanding of this pathology","volume":"27","author":"Rivero","year":"2007","journal-title":"Crit. Rev. Immunol."},{"key":"2025032406485889300_r5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.clim.2005.03.011","article-title":"Presence of INFgamma-secreting lymphocytes specific to prostate antigens in a group of chronic prostatitis patients","volume":"116","author":"Motrich","year":"2005","journal-title":"Clin. Immunol."},{"key":"2025032406485889300_r6","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0090-4295(97)00456-1","article-title":"Autoimmune prostatitis: evidence of T cell reactivity with normal prostatic proteins","volume":"50","author":"Alexander","year":"1997","journal-title":"Urology"},{"key":"2025032406485889300_r7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1046\/j.1365-2249.2002.01853.x","article-title":"Autoimmune T cell responses to seminal plasma in chronic pelvic pain syndrome (CPPS)","volume":"128","author":"Batstone","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"2025032406485889300_r8","first-page":"2031","article-title":"An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans","volume":"119","author":"Hou","year":"2009","journal-title":"J. Clin. Invest."},{"key":"2025032406485889300_r9","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0090-4295(98)00390-2","article-title":"Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis\/chronic pelvic pain syndrome","volume":"52","author":"Alexander","year":"1998","journal-title":"Urology"},{"key":"2025032406485889300_r10","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0022-5347(05)67497-6","article-title":"IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis","volume":"164","author":"Nadler","year":"2000","journal-title":"J. Urol."},{"key":"2025032406485889300_r11","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1093\/humrep\/dei073","article-title":"Reduced semen quality in chronic prostatitis patients that have cellular autoimmune response to prostate antigens","volume":"20","author":"Motrich","year":"2005","journal-title":"Hum. Reprod."},{"key":"2025032406485889300_r12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000052415","article-title":"Noninflammatory chronic pelvic pain syndrome: immunological study in blood, ejaculate and prostate tissue","volume":"39","author":"John","year":"2001","journal-title":"Eur. Urol."},{"key":"2025032406485889300_r13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-3083.2007.01971.x","article-title":"Autoimmune prostatitis: state of the art","volume":"66","author":"Motrich","year":"2007","journal-title":"Scand. J. Immunol."},{"key":"2025032406485889300_r14","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1006\/jaut.1998.0248","article-title":"Non-obese diabetic (NOD) mice are genetically susceptible to experimental autoimmune prostatitis (EAP)","volume":"11","author":"Rivero","year":"1998","journal-title":"J. Autoimmun."},{"key":"2025032406485889300_r15","doi-asserted-by":"crossref","first-page":"957","DOI":"10.4049\/jimmunol.177.2.957","article-title":"Pathogenic consequences in semen quality of an autoimmune response against the prostate gland: from animal models to human disease","volume":"177","author":"Motrich","year":"2006","journal-title":"J. Immunol."},{"key":"2025032406485889300_r16","doi-asserted-by":"crossref","first-page":"R1268","DOI":"10.1152\/ajpregu.00836.2007","article-title":"Experimental autoimmune prostatitis induces chronic pelvic pain","volume":"294","author":"Rudick","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2025032406485889300_r17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0022-5347(17)32871-9","article-title":"Development of a mouse model for nonbacterial prostatitis","volume":"152","author":"Keetch","year":"1994","journal-title":"J. Urol."},{"key":"2025032406485889300_r18","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.4049\/jimmunol.179.3.1559","article-title":"Spontaneous and prostatic steroid binding protein peptide-induced autoimmune prostatitis in the nonobese diabetic mouse","volume":"179","author":"Penna","year":"2007","journal-title":"J. Immunol."},{"key":"2025032406485889300_r19","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.juro.2009.11.008","article-title":"Crucial role of interferon-\u03b3 in experimental autoimmune prostatitis","volume":"183","author":"Motrich","year":"2010","journal-title":"J. Urol."},{"key":"2025032406485889300_r20","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.coi.2011.08.007","article-title":"The many faces of Th17 cells","volume":"23","author":"Peters","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"2025032406485889300_r21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1042\/BJ20081969","article-title":"Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation","volume":"418","author":"Ward","year":"2009","journal-title":"Biochem. J."},{"key":"2025032406485889300_r22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1074-7613(01)00261-8","article-title":"Chemokines and the tissue-specific migration of lymphocytes","volume":"16","author":"Kunkel","year":"2002","journal-title":"Immunity"},{"key":"2025032406485889300_r23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cytogfr.2007.01.004","article-title":"The essential role of chemokines in the selective regulation of lymphocyte homing","volume":"18","author":"Bono","year":"2007","journal-title":"Cytokine Growth Factor Rev."},{"key":"2025032406485889300_r24","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/ni1539","article-title":"TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology","volume":"8","author":"McGeachy","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025032406485889300_r25","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1111\/j.1476-5381.2009.00528.x","article-title":"The chemokine receptor antagonist, TAK-779, decreased experimental autoimmune encephalomyelitis by reducing inflammatory cell migration into the central nervous system, without affecting T cell function","volume":"158","author":"Ni","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"2025032406485889300_r26","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1183\/09031936.00111507","article-title":"A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation","volume":"31","author":"Suzaki","year":"2008","journal-title":"Eur. Respir. J."},{"key":"2025032406485889300_r27","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1002\/eji.200939722","article-title":"Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity","volume":"39","author":"Sallusto","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"2025032406485889300_r28","doi-asserted-by":"crossref","first-page":"7414","DOI":"10.4049\/jimmunol.180.11.7414","article-title":"Both Th1 and Th17 are immunopathogenic but differ in other key biological activities","volume":"180","author":"Cox","year":"2008","journal-title":"J. Immunol."},{"key":"2025032406485889300_r29","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.2337\/db08-1113","article-title":"Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice","volume":"58","author":"Emamaullee","year":"2009","journal-title":"Diabetes"},{"key":"2025032406485889300_r30","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1172\/JCI37865","article-title":"Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD\/SCID recipient mice","volume":"119","author":"Bending","year":"2009","journal-title":"J. Clin. Invest."},{"key":"2025032406485889300_r31","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/ni1207-1281","article-title":"IL-10 or not IL-10: that is the question","volume":"8","author":"Jankovic","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025032406485889300_r32","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/eji.200838475","article-title":"Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells","volume":"39","author":"Martin-Orozco","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"2025032406485889300_r33","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.4049\/jimmunol.1001864","article-title":"Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-mediated Th17 bias","volume":"186","author":"Lau","year":"2011","journal-title":"J. Immunol."},{"key":"2025032406485889300_r34","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.4049\/jimmunol.0902822","article-title":"Th17 polarized cells from nonobese diabetic mice following mycobacterial adjuvant immunotherapy delay type 1 diabetes","volume":"184","author":"Nikoopour","year":"2010","journal-title":"J. Immunol."},{"key":"2025032406485889300_r35","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.4049\/jimmunol.1001472","article-title":"NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity","volume":"185","author":"Tse","year":"2010","journal-title":"J. Immunol."},{"key":"2025032406485889300_r36","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4049\/jimmunol.1101215","article-title":"IL-17 silencing does not protect nonobese diabetic mice from autoimmune diabetes","volume":"188","author":"Joseph","year":"2012","journal-title":"J. Immunol."},{"key":"2025032406485889300_r37","doi-asserted-by":"crossref","first-page":"11548","DOI":"10.1073\/pnas.1108924108","article-title":"Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice","volume":"108","author":"Kriegel","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032406485889300_r38","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/ni.1736","article-title":"A protective function for interleukin 17A in T cell-mediated intestinal inflammation","volume":"10","author":"O\u2019Connor","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025032406485889300_r39","first-page":"121","article-title":"CXCL10\/IP-10 in infectious diseases pathogenesis and potential therapeutic implications","volume":"22","author":"Liu","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"key":"2025032406485889300_r40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/mi.2008.84","article-title":"The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut","volume":"2","author":"Wang","year":"2009","journal-title":"Mucosal Immunol."},{"key":"2025032406485889300_r41","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1600-065X.2012.01140.x","article-title":"T-cell trafficking in the central nervous system","volume":"248","author":"Sallusto","year":"2012","journal-title":"Immunol. Rev."},{"key":"2025032406485889300_r42","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ni.1716","article-title":"C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE","volume":"10","author":"Reboldi","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025032406485889300_r43","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.diff.2011.04.003","article-title":"Chemokines and BPH\/LUTS","volume":"82","author":"Macoska","year":"2011","journal-title":"Differentiation"},{"key":"2025032406485889300_r44","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.urology.2009.02.064","article-title":"Evaluation of interleukin-8 in expressed prostatic secretion as a reliable biomarker of inflammation in benign prostatic hyperplasia","volume":"74","author":"Liu","year":"2009","journal-title":"Urology"},{"key":"2025032406485889300_r45","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/j.juro.2008.01.028","article-title":"Monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha as possible biomarkers for the chronic pelvic pain syndrome","volume":"179","author":"Desireddi","year":"2008","journal-title":"J. Urol."},{"key":"2025032406485889300_r46","doi-asserted-by":"crossref","first-page":"R580","DOI":"10.1152\/ajpregu.00240.2012","article-title":"CCL2 and CCL3 are essential mediators of pelvic pain in experimental autoimmune prostatitis","volume":"303","author":"Quick","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/190\/7\/3121\/62506027\/1202482.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/190\/7\/3121\/62506027\/1202482.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T01:02:38Z","timestamp":1742950958000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/190\/7\/3121\/8004283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,1]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,4,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1202482","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,4]]},"published":{"date-parts":[[2013,4,1]]}}}