{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:27:39Z","timestamp":1787030859983,"version":"build-2736575974"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>NF-\u03baB is one of the key transcription factors activated by receptor activator of NF-\u03baB ligand (RANKL) during osteoclast differentiation. The 8-kDa dynein L chain (LC8) was previously identified as a novel NF-\u03baB regulator. However, its physiological role as an NF-\u03baB inhibitor remains elusive. In this study, we showed the inhibitory role of LC8 in RANKL-induced osteoclastogenesis and signaling pathways and its protective role in osteolytic animal models. LC8 suppressed RANKL-induced osteoclast differentiation, actin ring formation, and osteoclastic bone resorption. LC8 inhibited RANKL-induced phosphorylation and subsequent degradation of I\u03baB\u03b1, the expression of c-Fos, and the consequent activation of NFATc1, which is a pivotal determinant of osteoclastogenesis. LC8 also inhibited RANKL-induced activation of JNK and ERK. LC8-transgenic mice exhibited a mild osteopetrotic phenotype. Moreover, LC8 inhibited inflammation-induced bone erosion and protected against ovariectomy-induced bone loss in mice. Thus, our results suggest that LC8 inhibits osteoclast differentiation by regulating NF-\u03baB and MAPK pathways and provide the molecular basis of a new strategy for treating osteoporosis and other bone diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1202525","type":"journal-article","created":{"date-parts":[[2013,1,5]],"date-time":"2013-01-05T02:24:25Z","timestamp":1357352665000},"page":"1312-1318","source":"Crossref","is-referenced-by-count":20,"title":["Dynein Light Chain LC8 Inhibits Osteoclast Differentiation and Prevents Bone Loss in Mice"],"prefix":"10.1093","volume":"190","author":[{"given":"Hyeryeon","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Life and Pharmaceutical Sciences, Department of Life Sciences, and Research Center for Cellular Homeostasis, Ewha Womans University , Seoul 120-750,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungha","family":"Hyeon","sequence":"additional","affiliation":[{"name":"Division of Life and Pharmaceutical Sciences, Department of Life Sciences, and Research Center for Cellular Homeostasis, Ewha Womans University , Seoul 120-750,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Life and Pharmaceutical Sciences, Department of Life Sciences, and Research Center for Cellular Homeostasis, Ewha Womans University , Seoul 120-750,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoohee","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Life and Pharmaceutical Sciences, Department of Life Sciences, and Research Center for Cellular Homeostasis, Ewha Womans University , Seoul 120-750,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Huh","sequence":"additional","affiliation":[{"name":"Division of Life and Pharmaceutical Sciences, Department of Life Sciences, and Research Center for Cellular Homeostasis, Ewha Womans University , Seoul 120-750,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doo Ri","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Life and Pharmaceutical Sciences, Department of Life Sciences, and Research Center for Cellular Homeostasis, Ewha Womans University , Seoul 120-750,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyojung","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Life and Pharmaceutical Sciences, Department of Life Sciences, and Research Center for Cellular Homeostasis, Ewha Womans University , Seoul 120-750,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hyun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Health Sciences, Institute of Medical Engineering, Yonsei University , Wonju 220-710,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Health Sciences, Institute of Medical Engineering, Yonsei University , Wonju 220-710,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Life and Pharmaceutical Sciences, Department of Life Sciences, and Research Center for Cellular Homeostasis, Ewha Womans University , Seoul 120-750,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woojin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Life and Pharmaceutical Sciences, Department of Life Sciences, and Research Center for Cellular Homeostasis, Ewha Womans University , Seoul 120-750,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"2025032406295303900_r1","first-page":"115","article-title":"Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis","volume":"21","author":"Manolagas","year":"2000","journal-title":"Endocr. 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