{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T04:02:17Z","timestamp":1743048137650,"version":"3.40.3"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Experimental autoimmune thyroiditis, induced in mice after challenge with thyroglobulin (Tg), is known to be under the genetic control of the H2Ak locus. Because cathepsins are known to influence proteolytic processing of Tg in vivo, we examined in this study whether putative H2Ak-binding Tg epitopes, located near cathepsin cleavage sites within mouse Tg, have immunopathogenic properties. Cathepsin L, B, and D cleavage sites in mouse Tg were predicted based on homology with known cathepsin cleavage sites in rabbit Tg. We used an algorithm-based approach to identify H2Ak-binding motifs within 20-aa residue segments adjacent to cathepsin cleavage sites, and five 12mer peptides encompassing these sequences were synthesized. Two of them, p2369 (aa 2369\u20132380) and p2439 (aa 2439\u20132450) were immunogenic, eliciting significant proliferative T cell responses using lymph node cells from peptide-primed mice and production of IL-2 and IFN-\u03b3 in recall assays in vitro. Both peptides induced experimental autoimmune thyroiditis upon direct challenge of CBA\/J mice with peptide in CFA and by adoptive transfer of peptide-primed lymph node cells into naive recipient hosts, but neither peptide was characterized as dominant.<\/jats:p>","DOI":"10.4049\/jimmunol.1202529","type":"journal-article","created":{"date-parts":[[2013,1,12]],"date-time":"2013-01-12T06:45:04Z","timestamp":1357973104000},"page":"1466-1471","source":"Crossref","is-referenced-by-count":3,"title":["Identification of Pathogenic T Cell Epitopes Near Cathepsin Cleavage Sites in Thyroglobulin"],"prefix":"10.1093","volume":"190","author":[{"given":"Panayota","family":"Kolypetri","sequence":"first","affiliation":[{"name":"Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland , St. John\u2019s, Newfoundland and Labrador A1B 3V6,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland , St. John\u2019s, Newfoundland and Labrador A1B 3V6,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Carayanniotis","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland , St. John\u2019s, Newfoundland and Labrador A1B 3V6,","place":["Canada"]},{"name":"Division of Endocrinology, Faculty of Medicine, Memorial University of Newfoundland , St. John\u2019s, Newfoundland and Labrador A1B 3V6,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,2,15]]},"reference":[{"key":"2025032406332583600_r1","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1084\/jem.145.5.1250","article-title":"Induction of autoimmunity in good and poor responder mice with mouse thyroglobulin and lipopolysaccharide","volume":"145","author":"Esquivel","year":"1977","journal-title":"J. Exp. Med."},{"key":"2025032406332583600_r2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.4049\/jimmunol.106.3.698","article-title":"Murine thyroiditis: importance of adjuvant and mouse strain for the induction of thyroid lesions","volume":"106","author":"Rose","year":"1971","journal-title":"J. Immunol."},{"key":"2025032406332583600_r3","first-page":"788","article-title":"Autoimmune thyroid disease: further developments in our understanding","volume":"15","author":"Weetman","year":"1994","journal-title":"Endocr. Rev."},{"key":"2025032406332583600_r4","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.174.4014.1137","article-title":"Autoimmune murine thyroiditis relation to histocompatibility (H-2) type","volume":"174","author":"Vladutiu","year":"1971","journal-title":"Science"},{"key":"2025032406332583600_r5","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/BF00364266","article-title":"Regulation of experimental autoimmune thyroiditis: mapping of susceptibility to the I-A subregion of the mouse H-2","volume":"15","author":"Beisel","year":"1982","journal-title":"Immunogenetics"},{"key":"2025032406332583600_r6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s002510050277","article-title":"Role of mouse and human class II transgenes in susceptibility to and protection against mouse autoimmune thyroiditis","volume":"46","author":"Kong","year":"1997","journal-title":"Immunogenetics"},{"key":"2025032406332583600_r7","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0008-8749(85)90394-6","article-title":"Induction of experimental autoimmune thyroiditis in mice with in vitro activated splenic T cells","volume":"93","author":"Braley-Mullen","year":"1985","journal-title":"Cell. Immunol."},{"key":"2025032406332583600_r8","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.4049\/jimmunol.131.5.2316","article-title":"T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice","volume":"131","author":"Maron","year":"1983","journal-title":"J. Immunol."},{"key":"2025032406332583600_r9","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.4049\/jimmunol.138.4.1092","article-title":"Transfer of experimental autoimmune thyroiditis with T cell clones","volume":"138","author":"Romball","year":"1987","journal-title":"J. Immunol."},{"key":"2025032406332583600_r10","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0008-8749(75)80010-4","article-title":"Cellular basis of the genetic control of immune responsiveness to murine thyroglobulin in mice","volume":"17","author":"Vladutiu","year":"1975","journal-title":"Cell. Immunol."},{"key":"2025032406332583600_r11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0008-8749(89)90085-3","article-title":"Depletion of L3T4+ and Lyt-2+ cells by rat monoclonal antibodies alters the development of adoptively transferred experimental autoimmune thyroiditis","volume":"122","author":"Flynn","year":"1989","journal-title":"Cell. Immunol."},{"key":"2025032406332583600_r12"},{"key":"2025032406332583600_r13","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0140-6736(56)92249-8","article-title":"Autoantibodies in Hashimoto\u2019s disease","volume":"268","author":"Roitt","year":"1956","journal-title":"Lancet"},{"key":"2025032406332583600_r14","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1089\/thy.2007.0199","article-title":"Recognition of thyroglobulin by T cells: the role of iodine","volume":"17","author":"Carayanniotis","year":"2007","journal-title":"Thyroid"},{"key":"2025032406332583600_r15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/clin.1997.4428","article-title":"Cloning and characterization of murine thyroglobulin cDNA","volume":"85","author":"Caturegli","year":"1997","journal-title":"Clin. Immunol. Immunopathol."},{"key":"2025032406332583600_r16","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.4049\/jimmunol.149.3.1039","article-title":"Identification of a thyroiditogenic sequence within the thyroglobulin molecule","volume":"149","author":"Chronopoulou","year":"1992","journal-title":"J. Immunol."},{"key":"2025032406332583600_r17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cellimm.2004.07.002","article-title":"Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis","volume":"229","author":"Flynn","year":"2004","journal-title":"Cell. Immunol."},{"key":"2025032406332583600_r18","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.4049\/jimmunol.176.7.4479","article-title":"Iodination of tyrosyls in thyroglobulin generates neoantigenic determinants that cause thyroiditis","volume":"176","author":"Li","year":"2006","journal-title":"J. Immunol."},{"key":"2025032406332583600_r19","doi-asserted-by":"crossref","first-page":"5332","DOI":"10.4049\/jimmunol.169.9.5332","article-title":"Delineation of five thyroglobulin T cell epitopes with pathogenic potential in experimental autoimmune thyroiditis","volume":"169","author":"Verginis","year":"2002","journal-title":"J. Immunol."},{"key":"2025032406332583600_r20","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.4049\/jimmunol.148.11.3405","article-title":"Characterization and sequencing of a 40-amino-acid peptide from human thyroglobulin inducing experimental autoimmune thyroiditis","volume":"148","author":"Texier","year":"1992","journal-title":"J. Immunol."},{"key":"2025032406332583600_r21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1084\/jem.174.2.363","article-title":"Identification of a thyroxine-containing self-epitope of thyroglobulin which triggers thyroid autoreactive T cells","volume":"174","author":"Champion","year":"1991","journal-title":"J. Exp. Med."},{"key":"2025032406332583600_r22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0065-2776(08)00606-8","article-title":"Peptides presented in vivo by HLA-DR in thyroid autoimmunity","volume":"99","author":"Muix\u00ed","year":"2008","journal-title":"Adv. Immunol."},{"key":"2025032406332583600_r23","doi-asserted-by":"crossref","first-page":"795","DOI":"10.4049\/jimmunol.181.1.795","article-title":"Thyroglobulin peptides associate in vivo to HLA-DR in autoimmune thyroid glands","volume":"181","author":"Muix\u00ed","year":"2008","journal-title":"J. Immunol."},{"key":"2025032406332583600_r24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0165-2478(93)90036-2","article-title":"A common T-cell epitope between human thyroglobulin and human thyroid peroxidase is related to murine experimental autoimmune thyroiditis","volume":"37","author":"Hoshioka","year":"1993","journal-title":"Immunol. Lett."},{"key":"2025032406332583600_r25","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1146\/annurev.iy.11.040193.003501","article-title":"Dominance and crypticity of T cell antigenic determinants","volume":"11","author":"Sercarz","year":"1993","journal-title":"Annu. Rev. Immunol."},{"key":"2025032406332583600_r26","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/08916930310001602975","article-title":"The cryptic self in thyroid autoimmunity: the paradigm of thyroglobulin","volume":"36","author":"Carayanniotis","year":"2003","journal-title":"Autoimmunity"},{"key":"2025032406332583600_r27","doi-asserted-by":"crossref","first-page":"20198","DOI":"10.1016\/S0021-9258(18)54909-7","article-title":"Thyroglobulin processing by thyroidal proteases. Major sites of cleavage by cathepsins B, D, and L","volume":"266","author":"Dunn","year":"1991","journal-title":"J. Biol. Chem."},{"key":"2025032406332583600_r28","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/S0006-291X(05)81531-1","article-title":"The origin of the electrophoretic doublet of thyroglobulin","volume":"186","author":"Gentile","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025032406332583600_r29","doi-asserted-by":"crossref","first-page":"12620","DOI":"10.1016\/S0021-9258(18)63901-8","article-title":"Thyroid hormone residues are released from thyroglobulin with only limited alteration of the thyroglobulin structure","volume":"264","author":"Rousset","year":"1989","journal-title":"J. Biol. Chem."},{"key":"2025032406332583600_r30","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1432-1033.1993.tb18414.x","article-title":"Preferential sites of proteolytic cleavage of bovine, human and rat thyroglobulin. The use of limited proteolysis to detect solvent-exposed regions of the primary structure","volume":"218","author":"Gentile","year":"1993","journal-title":"Eur. J. Biochem."},{"key":"2025032406332583600_r31","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.4049\/jimmunol.162.10.5888","article-title":"Involvement of epitope mimicry in potentiation but not initiation of autoimmune disease","volume":"162","author":"Rao","year":"1999","journal-title":"J. Immunol."},{"key":"2025032406332583600_r32","doi-asserted-by":"crossref","first-page":"9909","DOI":"10.1073\/pnas.95.17.9909","article-title":"A single amino acid change in the acetylcholinesterase-like domain of thyroglobulin causes congenital goiter with hypothyroidism in the cog\/cog mouse: a model of human endoplasmic reticulum storage diseases","volume":"95","author":"Kim","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032406332583600_r33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0161-5890(94)90133-3","article-title":"Sequence features that correlate with MHC restriction","volume":"31","author":"Altuvia","year":"1994","journal-title":"Mol. Immunol."},{"key":"2025032406332583600_r34","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/BF01246676","article-title":"Mapping of thyroglobulin epitopes: presentation of a 9mer pathogenic peptide by different mouse MHC class II isotypes","volume":"40","author":"Rao","year":"1994","journal-title":"Immunogenetics"},{"key":"2025032406332583600_r35","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1046\/j.1365-2567.2003.01607.x","article-title":"Induction of murine thyroiditis by a non dominant E(k)-restricted peptide of human thyroglobulin","volume":"108","author":"Karras","year":"2003","journal-title":"Immunology"},{"key":"2025032406332583600_r36","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jaut.2005.02.002","article-title":"Human thyroglobulin peptide p2340 induces autoimmune thyroiditis in HLA-DR3 transgenic mice","volume":"24","author":"Karras","year":"2005","journal-title":"J. Autoimmun."},{"key":"2025032406332583600_r37","doi-asserted-by":"crossref","first-page":"34231","DOI":"10.1074\/jbc.M109.041574","article-title":"Employing a recombinant HLA-DR3 expression system to dissect major histocompatibility complex II-thyroglobulin peptide dynamism: a genetic, biochemical, and reverse immunological perspective","volume":"284","author":"Jacobson","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2025032406332583600_r38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1074\/jbc.M110.159483","article-title":"Revisiting iodination sites in thyroglobulin with an organ-oriented shotgun strategy","volume":"286","author":"Dedieu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2025032406332583600_r39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4049\/jimmunol.165.1.20","article-title":"Cutting edge: introduction of an endopeptidase cleavage motif into a determinant flanking region of hen egg lysozyme results in enhanced T cell determinant display","volume":"165","author":"Schneider","year":"2000","journal-title":"J. Immunol."},{"key":"2025032406332583600_r40","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/ni754","article-title":"Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP","volume":"3","author":"Manoury","year":"2002","journal-title":"Nat. Immunol."},{"key":"2025032406332583600_r41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/ni756","article-title":"Influence of a dominant cryptic epitope on autoimmune T cell tolerance","volume":"3","author":"Anderton","year":"2002","journal-title":"Nat. Immunol."},{"key":"2025032406332583600_r42","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1089\/10507250150500667","article-title":"Megalin in thyroid physiology and pathology","volume":"11","author":"Marin\u00f2","year":"2001","journal-title":"Thyroid"},{"key":"2025032406332583600_r43","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1172\/JCI15990","article-title":"Thyroid functions of mouse cathepsins B, K, and L","volume":"111","author":"Friedrichs","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2025032406332583600_r44","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2091-10-23","article-title":"Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions","volume":"10","author":"Jordans","year":"2009","journal-title":"BMC Biochem."},{"key":"2025032406332583600_r45","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1515\/BC.2007.155","article-title":"Two decades of thyroglobulin type-1 domain research","volume":"388","author":"Mihelic","year":"2007","journal-title":"Biol. Chem."},{"key":"2025032406332583600_r46","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0014-5793(96)00708-9","article-title":"The type-1 repeats of thyroglobulin regulate thyroglobulin degradation and T3, T4 release in thyrocytes","volume":"391","author":"Molina","year":"1996","journal-title":"FEBS Lett."},{"key":"2025032406332583600_r47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2567.2004.01861.x","article-title":"Thyroglobulin as an autoantigen: what can we learn about immunopathogenicity from the correlation of antigenic properties with protein structure?","volume":"112","author":"Gentile","year":"2004","journal-title":"Immunology"},{"key":"2025032406332583600_r48","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1126\/science.280.5362.450","article-title":"Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus","volume":"280","author":"Nakagawa","year":"1998","journal-title":"Science"},{"key":"2025032406332583600_r49","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1074-7613(00)80021-7","article-title":"Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice","volume":"10","author":"Nakagawa","year":"1999","journal-title":"Immunity"},{"key":"2025032406332583600_r50","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1172\/JCI1158","article-title":"Cathepsin S activity regulates antigen presentation and immunity","volume":"101","author":"Riese","year":"1998","journal-title":"J. Clin. Invest."},{"key":"2025032406332583600_r51","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1074-7613(00)80020-5","article-title":"Cathepsin S required for normal MHC class II peptide loading and germinal center development","volume":"10","author":"Shi","year":"1999","journal-title":"Immunity"},{"key":"2025032406332583600_r52","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1084\/jem.20020978","article-title":"Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages","volume":"197","author":"Beers","year":"2003","journal-title":"J. Exp. Med."},{"key":"2025032406332583600_r53","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/emboj\/18.4.793","article-title":"Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S","volume":"18","author":"Guncar","year":"1999","journal-title":"EMBO J."},{"key":"2025032406332583600_r54","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0140-6736(83)90629-3","article-title":"Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity","volume":"2","author":"Bottazzo","year":"1983","journal-title":"Lancet"},{"key":"2025032406332583600_r55","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/312639a0","article-title":"Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells","volume":"312","author":"Londei","year":"1984","journal-title":"Nature"},{"key":"2025032406332583600_r56","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1084\/jem.183.2.349","article-title":"Human self-reactive T cell clones expressing identical T cell receptor beta chains differ in their ability to recognize a cryptic self-epitope","volume":"183","author":"Quaratino","year":"1996","journal-title":"J. Exp. Med."},{"key":"2025032406332583600_r57","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0090-1229(90)90065-X","article-title":"Dendritic cells and class II MHC expression on thyrocytes during the autoimmune thyroid disease of the BB rat","volume":"55","author":"Voorby","year":"1990","journal-title":"Clin. Immunol. Immunopathol."},{"key":"2025032406332583600_r58","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1073\/pnas.0801973105","article-title":"Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules","volume":"105","author":"Calderon","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032406332583600_r59","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.coi.2011.11.005","article-title":"Antigen presentation events in autoimmune diabetes","volume":"24","author":"Calderon","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"2025032406332583600_r60","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jaut.2007.01.001","article-title":"Modifying effects of iodine on the immunogenicity of thyroglobulin peptides","volume":"28","author":"Li","year":"2007","journal-title":"J. Autoimmun."},{"key":"2025032406332583600_r61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellimm.2008.02.002","article-title":"A novel H2A-E+ transgenic model susceptible to human but not mouse thyroglobulin-induced autoimmune thyroiditis: identification of mouse pathogenic epitopes","volume":"251","author":"Brown","year":"2008","journal-title":"Cell. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/190\/4\/1466\/62501599\/1202529.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/190\/4\/1466\/62501599\/1202529.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T03:02:54Z","timestamp":1742958174000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/190\/4\/1466\/8004052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,2,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1202529","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[2013,2]]},"published":{"date-parts":[[2013,2]]}}}