{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:30:16Z","timestamp":1790166616558,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Beh\u00e7et\u2019s disease is a systemic inflammatory disorder with recurrent episodes of oral ulceration, skin lesions, genital ulceration, and intraocular inflammation (uveitis). The intraocular inflammation is strictly associated with Th effector cells. IL-22 is a member of the IL-10 cytokine family that is involved in inflammatory processes. Recently, Th22 cells were identified as a Th cell population that produces IL-22 and TNF-\u03b1 and are distinct from Th1, Th2, and Th17 cells. In this study, we established Th22-type T cell clones from ocular samples taken from Beh\u00e7et\u2019s disease patients with active uveitis. These clones produced large amounts of IL-22 and TNF-\u03b1 but not the Th1 cytokine IFN-\u03b3 and the Th17 cytokine IL-17. CD4+ T cells from the peripheral blood of Beh\u00e7et\u2019s disease patients differentiated into Th22 cells in the presence of IL-6 and TNF-\u03b1 in vitro. The polarized Th22 cell lines produced large amounts of IL-22, and the polarized Th1 and Th17 cells also produced IL-22. In the presence of anti\u2013TNF-\u03b1\u2013 and anti\u2013IL-6\u2013blocking Abs, Beh\u00e7et\u2019s disease Th22-type T cells failed to produce IL-22. In addition, infliximab-pretreated Th22 cells and Th22-type ocular T cells produced less IL-22 and TNF-\u03b1. Moreover, IL-22\u2013producing T cells were isolated from mice with experimental autoimmune uveitis, an animal model of Beh\u00e7et\u2019s disease, and the intraocular T cells from uveitis models produced large amounts of IL-22 in the presence of retinal Ags. Our results suggest that inflammatory cytokines IL-22 and TNF-\u03b1 may play a key role in the ocular immune response in Beh\u00e7et\u2019s disease.<\/jats:p>","DOI":"10.4049\/jimmunol.1202677","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T03:01:52Z","timestamp":1367290912000},"page":"5799-5808","source":"Crossref","is-referenced-by-count":74,"title":["Role of IL-22\u2013 and TNF-\u03b1\u2013Producing Th22 Cells in Uveitis Patients with Beh\u00e7et\u2019s Disease"],"prefix":"10.1093","volume":"190","author":[{"given":"Sunao","family":"Sugita","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences , Tokyo 113-8519,","place":["Japan"]},{"name":"Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology , Kobe 650-0047,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Kawazoe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences , Tokyo 113-8519,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayano","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences , Tokyo 113-8519,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsushi","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences , Tokyo 113-8519,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences , Tokyo 113-8519,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Keino","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyorin University School of Medicine , Tokyo 181-8611,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayo","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology , Kobe 650-0047,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences , Tokyo 113-8519,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,6,1]]},"reference":[{"key":"2025032407030312500_r1","first-page":"329","article-title":"Divergent cytokine production profile in Beh\u00e7et\u2019s disease. 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