{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:04:46Z","timestamp":1791065086025,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>TLR7 activation is implicated in the pathogenesis of systemic lupus erythematosus. Mice that overexpress TLR7 develop a lupus-like disease with autoantibodies and glomerulonephritis and early death. To determine whether degradation of the TLR7 ligand RNA would alter the course of disease, we created RNase A transgenic (Tg) mice. We then crossed the RNase Tg to TLR7 Tg mice to create TLR7 \u00d7 RNase double Tg (DTg) mice. DTg mice had a significantly increased survival associated with reduced activation of T and B lymphocytes and reduced kidney deposition of IgG and C3. We observed massive hepatic inflammation and cell death in TLR7 Tg mice. In contrast, hepatic inflammation and necrosis were strikingly reduced in DTg mice. These findings indicate that high concentrations of serum RNase protect against immune activation and inflammation associated with TLR7 stimulation and that RNase may be a useful therapeutic strategy in the prevention or treatment of inflammation in systemic lupus erythematosus and, possibly, liver diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1202689","type":"journal-article","created":{"date-parts":[[2013,2,5]],"date-time":"2013-02-05T04:05:25Z","timestamp":1360037125000},"page":"2536-2543","source":"Crossref","is-referenced-by-count":50,"title":["Increased Ribonuclease Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice"],"prefix":"10.1093","volume":"190","author":[{"given":"Xizhang","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Wiedeman","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H","family":"Teal","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L","family":"Hudkins","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E","family":"Alpers","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bolland","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergic and Infectious Diseases, National Institutes of Health , Rockville, MD 20852"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew B","family":"Buechler","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, WA 98195"},{"name":"Immunology Program, Benaroya Research Institute at Virginia Mason , Seattle, WA 98101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A","family":"Hamerman","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, WA 98195"},{"name":"Immunology Program, Benaroya Research Institute at Virginia Mason , Seattle, WA 98101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A","family":"Ledbetter","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denny","family":"Liggitt","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith B","family":"Elkon","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195"},{"name":"Department of Immunology, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"key":"2025032406441366400_r1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMra071297","article-title":"Systemic lupus erythematosus","volume":"358","author":"Rahman","year":"2008","journal-title":"N. 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