{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:15:34Z","timestamp":1789784134132,"version":"4.0.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recent studies have begun to define the role of micro-RNAs in regulating the immune response. Micro-RNA155 (mir-155) has been shown to play a role in germinal center formation, T cell inflammation, and regulatory T cell development. In this study, we evaluated the role of mir-155 in cytotoxic T cell function. We report in this study that mice lacking mir-155 have impaired CD8+ T cell responses to infections with lymphocytic choriomeningitis virus and the intracellular bacteria Listeria monocytogenes. We show by a series of adoptive transfer studies that the impaired CD8+ T cell response to L. monocytogenes is T cell intrinsic. In addition, we observed that CD8+ T cells lacking mir-155 have impaired activation of the prosurvival Akt pathway after TCR cross-linking. These data suggest that mir-155 may be a good target for therapies aimed at modulating immune responses.<\/jats:p>","DOI":"10.4049\/jimmunol.1202700","type":"journal-article","created":{"date-parts":[[2012,12,29]],"date-time":"2012-12-29T04:54:08Z","timestamp":1356756848000},"page":"1210-1216","source":"Crossref","is-referenced-by-count":104,"title":["Micro-RNA 155 Is Required for Optimal CD8+ T Cell Responses to Acute Viral and Intracellular Bacterial Challenges"],"prefix":"10.1093","volume":"190","author":[{"given":"Evan F","family":"Lind","sequence":"first","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute , Toronto, Ontario M5G 2C1,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha R","family":"Elford","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute , Toronto, Ontario M5G 2C1,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela S","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute , Toronto, Ontario M5G 2C1,","place":["Canada"]},{"name":"Department of Immunology, University of Toronto , Toronto, Ontario M5G 2M9,","place":["Canada"]},{"name":"Department of Medical Biophysics, University of Toronto , Toronto, Ontario M5G 2M9,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"2025032406304353900_r1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrm2085","article-title":"Illuminating the silence: understanding the structure and function of small RNAs","volume":"8","author":"Rana","year":"2007","journal-title":"Nat. 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