{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:59:41Z","timestamp":1777517981289,"version":"3.51.4"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alterations to dendritic cell (DC) progenitors in the bone marrow (BM) may contribute to long-lasting systemic immunosuppression (&amp;gt;28 d) following exposure of the skin of mice to erythemal UV radiation (UVR). DCs differentiated in vitro from the BM of mice 3 d after UVR (8 kJ\/m2) have a reduced capacity to initiate immunity (both skin and airways) when adoptively transferred into naive mice. Studies in IL-10\u2212\/\u2212 mice suggested that UV-induced IL-10 was not significantly involved. To investigate the immune capabilities of peripheral tissue DCs generated in vivo from the BM of UV-irradiated mice, chimeric mice were established. Sixteen weeks after reconstitution, contact hypersensitivity responses were significantly reduced in mice reconstituted with BM from UV-irradiated mice (UV-chimeric). When the dorsal skin of UV-chimeric mice was challenged with innate inflammatory agents, the hypertrophy induced in the draining lymph nodes was minimal and significantly less than that measured in control-chimeric mice challenged with the same inflammatory agent. When DCs were differentiated from the BM of UV-chimeric mice using FLT3 ligand or GM-CSF + IL-4, the cells maintained a reduced priming ability. The diminished responses in UV-chimeric mice were not due to different numerical or proportional reconstitution of BM or the hematopoietic cells in blood, lymph nodes, and skin. Erythemal UVR may imprint a long-lasting epigenetic effect on DC progenitors in the BM and alter the function of their terminally differentiated progeny.<\/jats:p>","DOI":"10.4049\/jimmunol.1202786","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T07:57:10Z","timestamp":1367481430000},"page":"5471-5484","source":"Crossref","is-referenced-by-count":40,"title":["Altered Immunity and Dendritic Cell Activity in the Periphery of Mice after Long-Term Engraftment with Bone Marrow from Ultraviolet-Irradiated Mice"],"prefix":"10.1093","volume":"190","author":[{"given":"Royce L X","family":"Ng","sequence":"first","affiliation":[{"name":"Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia , Perth 6008, Western Australia,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi M","family":"Scott","sequence":"additional","affiliation":[{"name":"Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia , Perth 6008, Western Australia,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah H","family":"Strickland","sequence":"additional","affiliation":[{"name":"Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia , Perth 6008, Western Australia,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley","family":"Gorman","sequence":"additional","affiliation":[{"name":"Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia , Perth 6008, Western Australia,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele A","family":"Grimbaldeston","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, South Australia Pathology , Adelaide 5000, South Australia,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Norval","sequence":"additional","affiliation":[{"name":"Biomedical Sciences, University of Edinburgh Medical School , Edinburgh EH8 9AG,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Waithman","sequence":"additional","affiliation":[{"name":"Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia , Perth 6008, Western Australia,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prue H","family":"Hart","sequence":"additional","affiliation":[{"name":"Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia , Perth 6008, Western Australia,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,6,1]]},"reference":[{"key":"2025032407030984400_r1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/j.1751-1097.2011.00969.x","article-title":"The consequences of UV-induced immunosuppression for human health","volume":"87","author":"Norval","year":"2011","journal-title":"Photochem. 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Pathol."},{"key":"2025032407030984400_r50","doi-asserted-by":"crossref","first-page":"11797","DOI":"10.1073\/pnas.91.25.11797","article-title":"Toxicity of 5-aza-2\u2032-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation","volume":"91","author":"J\u00fcttermann","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032407030984400_r51","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nm.2608","article-title":"Prostaglandin E2 promotes intestinal tumor growth via DNA methylation","volume":"18","author":"Xia","year":"2012","journal-title":"Nat. Med."},{"key":"2025032407030984400_r52","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/ni1503","article-title":"Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B","volume":"8","author":"Grimbaldeston","year":"2007","journal-title":"Nat. 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