{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:29:02Z","timestamp":1791091742785,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recently, patients with mutations in DOCK8 have been reported to have a combined immunodeficiency characterized by cutaneous viral infections and allergies. NK cells represent a first-line defense against viral infections, suggesting that DOCK8 might participate in NK cell function. In this study, we demonstrate that DOCK8-suppressed human NK cells showed defects in natural cytotoxicity as well as specific activating receptor-mediated NK cytotoxicity. Additionally, compared with control NK cells, NK cells depleted of DOCK8 showed defective conjugate formation, along with decreased polarization of LFA-1, F-actin, and cytolytic granules toward the cytotoxic synapse. Using a proteomic approach, we found that DOCK8 exists in a macromolecular complex with the Wiskott-Aldrich syndrome protein, an actin nucleation-promoting factor activated by CDC42, as well as talin, which is required for integrin-mediated adhesion. Taken together, our results demonstrate an important role for DOCK8 in NK cell effector function and provide important new mechanistic insight into how DOCK8 regulates F-actin and integrin-mediated adhesion in immune cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1202792","type":"journal-article","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T10:23:49Z","timestamp":1362219829000},"page":"3661-3669","source":"Crossref","is-referenced-by-count":107,"title":["Dedicator of Cytokinesis 8 Interacts with Talin and Wiskott-Aldrich Syndrome Protein To Regulate NK Cell Cytotoxicity"],"prefix":"10.1093","volume":"190","author":[{"given":"Hyoungjun","family":"Ham","sequence":"first","affiliation":[{"name":"Department of Immunology, College of Medicine, Mayo Clinic , Rochester, MN 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrice","family":"Guerrier","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton College , Northfield, MN 55057"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JungJin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Oncology Research, Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic , Rochester, MN 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee A","family":"Schoon","sequence":"additional","affiliation":[{"name":"Division of Oncology Research, Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic , Rochester, MN 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik L","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Immunology, College of Medicine, Mayo Clinic , Rochester, MN 55905"},{"name":"Biology Department, Bemidji State University , Bemidji, MN 56601"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Hamann","sequence":"additional","affiliation":[{"name":"Biology Department, Bemidji State University , Bemidji, MN 56601"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenkun","family":"Lou","sequence":"additional","affiliation":[{"name":"Division of Oncology Research, Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic , Rochester, MN 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D","family":"Billadeau","sequence":"additional","affiliation":[{"name":"Department of Immunology, College of Medicine, Mayo Clinic , Rochester, MN 55905"},{"name":"Division of Oncology Research, Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic , Rochester, MN 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,4,1]]},"reference":[{"key":"2025032406503839500_r1","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1242\/jcs.00219","article-title":"Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity","volume":"115","author":"C\u00f4t\u00e9","year":"2002","journal-title":"J. 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