{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:31:45Z","timestamp":1761489105615,"version":"3.40.3"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for adult T cell leukemia\/lymphoma (ATL) caused by human T cell leukemia virus type 1 (HTLV-1). We previously reported that Tax-specific CD8+ cytotoxic T lymphocyte (CTL) contributed to graft-versus-ATL effects in ATL patients after allo-HSCT. However, the role of HTLV-1\u2013specific CD4+ T cells in the effects remains unclear. In this study, we showed that Tax-specific CD4+ as well as CD8+ T cell responses were induced in some ATL patients following allo-HSCT. To further analyze HTLV-1\u2013specific CD4+ T cell responses, we identified a novel HLA-DRB1*0101\u2013restricted epitope, Tax155\u2013167, recognized by HTLV-1\u2013specific CD4+ Th1-like cells, a major population of HTLV-1\u2013specific CD4+ T cell line, which was established from an ATL patient at 180 d after allo-HSCT from an unrelated seronegative donor by in vitro stimulation with HTLV-1\u2013infected cells from the same patient. Costimulation of PBMCs with both the identified epitope (Tax155\u2013167) and known CTL epitope peptides markedly enhanced the expansion of Tax-specific CD8+ T cells in PBMCs compared with stimulation with CTL epitope peptide alone in all three HLA-DRB1*0101+ patients post\u2013allo-HSCT tested. In addition, direct detection using newly generated HLA-DRB1*0101\/Tax155\u2013167 tetramers revealed that Tax155\u2013167-specific CD4+ T cells were present in all HTLV-1\u2013infected individuals tested, regardless of HSCT. These results suggest that Tax155\u2013167 may be the dominant epitope recognized by HTLV-1\u2013specific CD4+ T cells in HLA-DRB1*0101+\u2013infected individuals and that Tax-specific CD4+ T cells may augment the graft-versus-Tax effects via efficient induction of Tax-specific CD8+ T cell responses.<\/jats:p>","DOI":"10.4049\/jimmunol.1202971","type":"journal-article","created":{"date-parts":[[2013,3,9]],"date-time":"2013-03-09T04:09:18Z","timestamp":1362802158000},"page":"4382-4392","source":"Crossref","is-referenced-by-count":10,"title":["Potential Contribution of a Novel Tax Epitope\u2013Specific CD4+ T Cells to Graft-versus-Tax Effect in Adult T Cell Leukemia Patients after Allogeneic Hematopoietic Stem Cell Transplantation"],"prefix":"10.1093","volume":"190","author":[{"given":"Yotaro","family":"Tamai","sequence":"first","affiliation":[{"name":"Department of Immunotherapeutics, Tokyo Medical and Dental University , Tokyo 113-8519,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiko","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Immunotherapeutics, Tokyo Medical and Dental University , Tokyo 113-8519,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Takamori","sequence":"additional","affiliation":[{"name":"Department of Immunotherapeutics, Tokyo Medical and Dental University , Tokyo 113-8519,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amane","family":"Sasada","sequence":"additional","affiliation":[{"name":"Department of Immunotherapeutics, Tokyo Medical and Dental University , Tokyo 113-8519,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuji","family":"Tanosaki","sequence":"additional","affiliation":[{"name":"Clinical Laboratories Division, National Cancer Center Hospital , Tokyo 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