{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:38:39Z","timestamp":1791398319381,"version":"4.3.3"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The molecular mechanisms of Fas (CD95\/Apo-1)-mediated apoptosis are increasingly understood. However, the role of Fas-mediated production of proinflammatory cytokines such as IL-18 and IL-1\u03b2 in bacterial infection is unclear. We demonstrate the importance of Fas-mediated signaling in IL-18\/IL-1\u03b2 production postinfection with Listeria monocytogenes without the contribution of caspase-1 inflammasome. IL-18\/IL-1\u03b2 production in L. monocytogenes\u2013infected peritoneal exudate cells from Fas-deficient mice was lower than those from wild type mice, indicating that Fas signaling contributes to cytokine production. L. monocytogenes infection induced Fas ligand expression on NK cells, which stimulates Fas expressed on the infected macrophages, leading to the production of IL-18\/IL-1\u03b2. This was independent of caspase-1, caspase-11, and nucleotide-binding domain and leucine-rich repeat\u2013containing receptors (NLRs) such as Nlrp3 and Nlrc4, but dependent on apoptosis-associated speck-like protein containing a caspase recruitment domain. Wild type cells exhibited caspase-8 activation, whereas Fas-deficient cells did not. L. monocytogenes\u2013induced caspase-8 activation was abrogated by inhibitor for intracellular reactive oxygen species, N-acetyl-l-cysteine. L. monocytogenes\u2013infected macrophages produced type-I IFNs such as IFN-\u03b21, which was required for Il18 gene expression. Thus, Fas signaling regulates innate inflammatory cytokine production in L. monocytogenes infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1203059","type":"journal-article","created":{"date-parts":[[2013,3,16]],"date-time":"2013-03-16T08:26:44Z","timestamp":1363422404000},"page":"4245-4254","source":"Crossref","is-referenced-by-count":28,"title":["Fas-Mediated Inflammatory Response in <i>Listeria monocytogenes<\/i> Infection"],"prefix":"10.1093","volume":"190","author":[{"given":"Ryosuke","family":"Uchiyama","sequence":"first","affiliation":[{"name":"Department of Microbiology, Hyogo College of Medicine , Nishinomiya, 663-8501,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Yonehara","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Biology, Graduate School of Biostudies, Kyoto University , Sakyo-ku, Kyoto, 606-8501,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Tsutsui","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hyogo College of Medicine , Nishinomiya, 663-8501,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,4,15]]},"reference":[{"key":"2025032406514497200_r1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.immuni.2009.01.001","article-title":"The many roles of FAS receptor signaling in the immune system","volume":"30","author":"Strasser","year":"2009","journal-title":"Immunity"},{"key":"2025032406514497200_r2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cell.2007.04.031","article-title":"The CD95 receptor: apoptosis revisited","volume":"129","author":"Peter","year":"2007","journal-title":"Cell"},{"key":"2025032406514497200_r3","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/3276","article-title":"Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand","volume":"4","author":"Miwa","year":"1998","journal-title":"Nat. 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