{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:12:51Z","timestamp":1792721571224,"version":"4.5.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pseudogout is an autoinflammatory condition triggered by calcium pyrophosphate dehydrate (CPPD) crystal deposition in the joints. The innate immune system is irritated by and responds to the presence of the crystals with an inflammatory response. The synovial fluid contains activated inflammatory macrophages and neutrophil granulocytes. Several details of crystal-induced macrophage activation were recently uncovered, but very little is known about interactions of CPPD crystals with neutrophils. In this study, we show that human neutrophils engulf CPPD crystals and form large amounts of neutrophil extracellular traps (NETs) in vitro. Released extracellular DNA binds myeloperoxidase and citrullinated histone H4. CPPD crystal\u2013stimulated neutrophils and their nuclear DNA undergo morphological changes characteristic for NET formation. The ERK\/MEK signaling pathway, heat shock protein 90, PI3K, and an intact cytoskeleton are required for CPPD-induced NET formation. Blocking crystal-activated respiratory burst has, however, no effect on NETs. Human neutrophils release IL-1\u03b2 and IL-8 in response to CPPD crystals, and blocking CXCR2, the main IL-8R, diminishes NET formation. Proinflammatory cytokines, TNF-\u03b1, GM-CSF, and IL-1\u03b2, increase NET release by the crystals. Enhanced bacterial killing by CPPD-induced NETs demonstrates their ability to cause cellular damage. Our work documents and provides details about extracellular trap release in human neutrophils activated by CPPD microcrystals. We suggest that crystal-triggered NET formation can be a novel contributor to inflammatory conditions observed in CPPD crystal\u2013driven synovitis.<\/jats:p>","DOI":"10.4049\/jimmunol.1203215","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T04:23:15Z","timestamp":1368678195000},"page":"6488-6500","source":"Crossref","is-referenced-by-count":78,"title":["Pseudogout-Associated Inflammatory Calcium Pyrophosphate Dihydrate Microcrystals Induce Formation of Neutrophil Extracellular Traps"],"prefix":"10.1093","volume":"190","author":[{"given":"Lan","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia , Athens, GA 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig P","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia , Athens, GA 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Buac","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Georgia , Athens, GA 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-goon","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia , Athens, GA 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Rada","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia , Athens, GA 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,6,15]]},"reference":[{"key":"2025032407080460300_r1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jbspin.2004.12.010","article-title":"Monosodium urate and calcium pyrophosphate dihydrate (CPPD) crystals, inflammation, and cellular signaling","volume":"72","author":"Liu-Bryan","year":"2005","journal-title":"Joint Bone Spine"},{"key":"2025032407080460300_r2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/BOR.0b013e3283432d1f","article-title":"Crystals, inflammation, and osteoarthritis","volume":"23","author":"Rosenthal","year":"2011","journal-title":"Curr. 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Rheumatol."},{"key":"2025032407080460300_r22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s10753-007-9047-x","article-title":"Neutrophil migration induced by IL-1beta depends upon LTB4 released by macrophages and upon TNF-alpha and IL-1beta released by mast cells","volume":"31","author":"Oliveira","year":"2008","journal-title":"Inflammation"},{"key":"2025032407080460300_r23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.imlet.2012.01.013","article-title":"The role of neutrophils in autoimmune diseases","volume":"143","author":"N\u00e9meth","year":"2012","journal-title":"Immunol. Lett."},{"key":"2025032407080460300_r24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cellsig.2003.07.003","article-title":"Calcium pyrophosphate dihydrate crystal associated induction of neutrophil activation and repression of TNF-alpha-induced apoptosis is mediated by the p38 MAP kinase","volume":"16","author":"Tudan","year":"2004","journal-title":"Cell. Signal."},{"key":"2025032407080460300_r25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00011-009-0073-z","article-title":"Calcium pyrophosphate dihydrate crystal-induced inhibition of neutrophil apoptosis: involvement of Bcl-2 family members","volume":"59","author":"Higo","year":"2010","journal-title":"Inflamm. 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Leukoc. Biol."},{"key":"2025032407080460300_r40","doi-asserted-by":"crossref","first-page":"849136","DOI":"10.1155\/2012\/849136","article-title":"The impact of various reactive oxygen species on the formation of neutrophil extracellular traps","volume":"2012","author":"Kirchner","year":"2012","journal-title":"Mediators Inflamm."},{"key":"2025032407080460300_r41","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1056\/NEJMoa1007097","article-title":"Residual NADPH oxidase and survival in chronic granulomatous disease","volume":"363","author":"Kuhns","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"2025032407080460300_r42","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000206173","article-title":"Modifications in the phagocytosis of human neutrophils induced by vinblastine and cytochalasin B: the effects of lithium","volume":"74","author":"Carulli","year":"1985","journal-title":"Acta Haematol."},{"key":"2025032407080460300_r43","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1042\/bj3290121","article-title":"Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function","volume":"329","author":"Coffer","year":"1998","journal-title":"Biochem. J."},{"key":"2025032407080460300_r44","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/j.1745-7254.2005.00235.x","article-title":"Molecular mechanism and regulation of autophagy","volume":"26","author":"Yang","year":"2005","journal-title":"Acta Pharmacol. 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Res.","author":"Zhao","year":"2012"},{"key":"2025032407080460300_r48","doi-asserted-by":"crossref","first-page":"32747","DOI":"10.1074\/jbc.M112.376566","article-title":"Heat shock protein 90 inhibitors reduce trafficking of ATP-gated P2X1 receptors and human platelet responsiveness","volume":"287","author":"Lalo","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2025032407080460300_r49","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1046\/j.1365-2249.1997.4011298.x","article-title":"The priming action of tumour necrosis factor-alpha (TNF-alpha) and granulocyte-macrophage colony-stimulating factor (GM-CSF) on neutrophils activated by inflammatory microcrystals","volume":"108","author":"Burt","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"2025032407080460300_r50","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.4049\/jimmunol.171.8.4392","article-title":"TNF-alpha induces phosphorylation of p47(phox) in human neutrophils: partial phosphorylation of p47phox is a common event of priming of human neutrophils by TNF-alpha and granulocyte-macrophage colony-stimulating factor","volume":"171","author":"Dewas","year":"2003","journal-title":"J. Immunol."},{"key":"2025032407080460300_r51","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/1529-0131(200005)43:5<1145::AID-ANR25>3.0.CO;2-T","article-title":"Extracellular signal-regulated kinase 1\/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells","volume":"43","author":"Liu","year":"2000","journal-title":"Arthritis Rheum."},{"key":"2025032407080460300_r52","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1189\/jlb.0208125","article-title":"The functional significance behind expressing two IL-8 receptor types on PMN","volume":"86","author":"Stillie","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"2025032407080460300_r53","doi-asserted-by":"crossref","first-page":"10095","DOI":"10.1074\/jbc.273.17.10095","article-title":"Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration","volume":"273","author":"White","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2025032407080460300_r54","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/nm.2847","article-title":"Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo","volume":"18","author":"Yipp","year":"2012","journal-title":"Nat. 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Immunol."},{"key":"2025032407080460300_r61","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.4049\/jimmunol.1201167","article-title":"A serpinB1 regulatory mechanism is essential for restricting neutrophil extracellular trap generation","volume":"189","author":"Farley","year":"2012","journal-title":"J. Immunol."},{"key":"2025032407080460300_r62","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fimmu.2013.00045","article-title":"NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury","volume":"4","author":"Almyroudis","year":"2013","journal-title":"Front. Immunol."},{"key":"2025032407080460300_r63","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.bbrc.2004.02.108","article-title":"Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC\/PKCdelta but not Akt","volume":"316","author":"Yamamori","year":"2004","journal-title":"Biochem. Biophys. Res. 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