{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:38:12Z","timestamp":1787769492679,"version":"build-2784847793"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We investigated the role of effector CD8 T cells in the pathogenesis of immune glomerular injury. BALB\/c mice are not prone to autoimmune disease, but after 12 immunizations with OVA they developed a variety of autoantibodies and glomerulonephritis accompanied by immune complex (IC) deposition. In these mice, IFN-\u03b3\u2013producing effector CD8 T cells were significantly increased concomitantly with glomerulonephritis. In contrast, after 12 immunizations with keyhole limpet hemocyanin, although autoantibodies appeared, IFN-\u03b3\u2013producing effector CD8 T cells did not develop, and glomerular injury was not induced. In \u03b22-microglobulin\u2013deficient mice lacking CD8 T cells, glomerular injury was not induced after 12 immunizations with OVA, despite massive deposition of IC in the glomeruli. In mice containing a targeted disruption of the exon encoding the membrane-spanning region of the Ig \u03bc-chain (\u03bcMT mice), 12 immunizations with OVA induced IFN-\u03b3\u2013producing effector CD8 T cells but not IC deposition or glomerular injury. When CD8 T cells from mice immunized 12 times with OVA were transferred into naive recipients, glomerular injury could be induced, but only when a single injection of OVA was also given simultaneously. Importantly, injection of OVA could be replaced by one injection of the sera from mice that had been fully immunized with OVA. This indicates that deposition of IC is required for effector CD8 T cells to cause immune tissue injury. Thus, in a mouse model of systemic lupus erythematosus, glomerular injury is caused by effector CD8 T cells that recognize Ag presented as IC on the target renal tissue.<\/jats:p>","DOI":"10.4049\/jimmunol.1203217","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T21:44:48Z","timestamp":1369863888000},"page":"91-96","source":"Crossref","is-referenced-by-count":13,"title":["IFN-\u03b3\u2013Producing Effector CD8 T Lymphocytes Cause Immune Glomerular Injury by Recognizing Antigen Presented as Immune Complex on Target Tissue"],"prefix":"10.1093","volume":"191","author":[{"given":"Ken","family":"Tsumiyama","sequence":"first","affiliation":[{"name":"Department of Medicine, Kyushu University Beppu Hospital , Beppu 874-0838,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hashiramoto","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Kobe University Graduate School of Health Science , Kobe 654-0142,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Takimoto","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Kobe University Graduate School of Health Science , Kobe 654-0142,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiyo","family":"Tsuji-Kawahara","sequence":"additional","affiliation":[{"name":"Department of Immunology, Kinki University School of Medicine , Osaka-Sayama 589-8511,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Department of Immunology, Kinki University School of Medicine , Osaka-Sayama 589-8511,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Shiozawa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Kyushu University Beppu Hospital , Beppu 874-0838,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,7,1]]},"reference":[{"key":"2025032405042606800_r1","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1172\/JCI105479","article-title":"Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus","volume":"45","author":"Tan","year":"1966","journal-title":"J. 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