{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:50:20Z","timestamp":1790650220975,"version":"4.1.0"},"reference-count":93,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The Gram-negative bacterium Yersinia pestis causes plague, a rapidly progressing and often fatal disease. The formation of fibrin at sites of Y. pestis infection supports innate host defense against plague, perhaps by providing a nondiffusible spatial cue that promotes the accumulation of inflammatory cells expressing fibrin-binding integrins. This report demonstrates that fibrin is an essential component of T cell\u2013mediated defense against plague but can be dispensable for Ab-mediated defense. Genetic or pharmacologic depletion of fibrin abrogated innate and T cell\u2013mediated defense in mice challenged intranasally with Y. pestis. The fibrin-deficient mice displayed reduced survival, increased bacterial burden, and exacerbated hemorrhagic pathology. They also showed fewer neutrophils within infected lung tissue and reduced neutrophil viability at sites of liver infection. Depletion of neutrophils from wild-type mice weakened T cell\u2013mediated defense against plague. The data suggest that T cells combat plague in conjunction with neutrophils, which require help from fibrin to withstand Y. pestis encounters and effectively clear bacteria.<\/jats:p>","DOI":"10.4049\/jimmunol.1203253","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T05:23:32Z","timestamp":1363238612000},"page":"4149-4161","source":"Crossref","is-referenced-by-count":28,"title":["Fibrin Facilitates Both Innate and T Cell\u2013Mediated Defense against <i>Yersinia pestis<\/i>"],"prefix":"10.1093","volume":"190","author":[{"given":"Deyan","family":"Luo","sequence":"first","affiliation":[{"name":"Trudeau Institute , Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jr-Shiuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Trudeau Institute , Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A","family":"Parent","sequence":"additional","affiliation":[{"name":"Trudeau Institute , Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isis","family":"Mullarky-Kanevsky","sequence":"additional","affiliation":[{"name":"Trudeau Institute , Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M","family":"Szaba","sequence":"additional","affiliation":[{"name":"Trudeau Institute , Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence W","family":"Kummer","sequence":"additional","affiliation":[{"name":"Trudeau Institute , Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra K","family":"Duso","sequence":"additional","affiliation":[{"name":"Trudeau Institute , Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tighe","sequence":"additional","affiliation":[{"name":"Trudeau Institute , Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Hill","sequence":"additional","affiliation":[{"name":"Defence Science and Technology Laboratory , Porton Down SP4 0JQ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Oregon Health and Science University , Portland, OR 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Mackman","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, University of North Carolina , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gailani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vanderbilt University , Nashville, TN 37232"},{"name":"Department of Medicine, Vanderbilt University , Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T","family":"Smiley","sequence":"additional","affiliation":[{"name":"Trudeau Institute , Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,4,15]]},"reference":[{"key":"2025032406550241000_r1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/CMR.10.1.35","article-title":"Yersinia pestis\u2014etiologic agent of plague","volume":"10","author":"Perry","year":"1997","journal-title":"Clin. 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