{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:33:38Z","timestamp":1787506418131,"version":"build-2736575974"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although studies investigating the nature of Ab-secreting cells (ASCs) during acute infection with influenza or dengue virus found that the ASC response was dominated by virus-specific IgG secretion, the Ag specificity and phenotype of ASCs during primary acute viral infection were not identified. To this end, we investigated the nature of ASCs in direct ex vivo assays from patients with acute hepatitis A caused by primary infection with hepatitis A virus (HAV). We found that the frequency of CD27highCD38high ASCs was markedly increased in the peripheral blood during the acute phase of HAV infection. Moreover, substantial numbers of ASCs were non-HAV\u2013specific and dominantly secreted IgM. We detected HAV-specific ASCs by staining with fluorochrome-tagged HAV-VP1 protein. As compared with HAV-specific ASCs, non-HAV\u2013specific ASCs were Ki-67lowCD138highCD31highCD38high, demonstrating that non-HAV\u2013specific ASCs had a bone marrow plasma cell\u2013like phenotype whereas HAV-specific ASCs had a phenotype typical of circulating plasmablasts. These data suggest that non-HAV\u2013specific ASCs might be mobilized plasma cells from the bone marrow or the spleen, whereas HAV-specific ASCs were newly generated plasmablasts. In this study, we provide evidence that pre-existing plasma cells are released into the circulation and contribute to Ag-nonspecific secretion of IgM during primary HAV infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1203540","type":"journal-article","created":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T01:15:07Z","timestamp":1370049307000},"page":"127-134","source":"Crossref","is-referenced-by-count":17,"title":["Antibody-Secreting Cells with a Phenotype of Ki-67low, CD138high, CD31high, and CD38high Secrete Nonspecific IgM during Primary Hepatitis A Virus Infection"],"prefix":"10.1093","volume":"191","author":[{"given":"Seokchan","family":"Hong","sequence":"first","affiliation":[{"name":"Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology , Daejeon 305-701,","place":["Republic of Korea"]},{"name":"Laboratory of Molecular Biology, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology , Daejeon 305-701,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Woong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chung-Ang University Hospital , Seoul 156-756,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Yeop","family":"Chang","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology , Daejeon 305-701,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sooseong","family":"You","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology , 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Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongeun","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yonsei University College of Medicine , Seoul 120-752,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Hyub","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yonsei University College of Medicine , Seoul 120-752,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ook Joon","family":"Yoo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology , Daejeon 305-701,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui-Cheol","family":"Shin","sequence":"additional","affiliation":[{"name":"Laboratory of 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