{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:07:09Z","timestamp":1791281229185,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The development of animal models that mimic human allergic responses is crucial to study the pathophysiology of disease and to generate new therapeutic methodologies. Humanized mice reconstituted with human immune systems are essential to study human immune reactions in vivo and are expected to be useful for studying human allergies. However, application of this technology to the study of human allergies has been limited, largely because of the poor development of human myeloid cells, especially granulocytes and mast cells, which are responsible for mediating allergic diseases, in conventional humanized mice. In this study, we developed a novel transgenic (Tg) strain, NOD\/Shi-scid-IL2r\u03b3null (NOG), bearing human IL-3 and GM-CSF genes (NOG IL-3\/GM\u2013Tg). In this strain, a large number of human myeloid cells of various lineages developed after transplantation of human CD34+ hematopoietic stem cells. Notably, mature basophils and mast cells expressing Fc\u03b5RI were markedly increased. These humanized NOG IL-3\/GM\u2013Tg mice developed passive cutaneous anaphylaxis reactions when administered anti\u20134-hydroxy-3-nitrophenylacetyl IgE Abs and 4-hydroxy-3-nitrophenylacetyl. More importantly, a combination of serum from Japanese cedar pollinosis patients and cedar pollen extract also elicited strong passive cutaneous anaphylaxis responses in mice. Thus, to our knowledge, our NOG IL-3\/GM\u2013Tg mice are the first humanized mouse model to enable the study of human allergic responses in vivo and are excellent tools for preclinical studies of allergic diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1203543","type":"journal-article","created":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T05:10:15Z","timestamp":1376716215000},"page":"2890-2899","source":"Crossref","is-referenced-by-count":156,"title":["Establishment of a Human Allergy Model Using Human IL-3\/GM-CSF\u2013Transgenic NOG Mice"],"prefix":"10.1093","volume":"191","author":[{"given":"Ryoji","family":"Ito","sequence":"first","affiliation":[{"name":"Central Institute for Experimental Animals , Kawasaki-ku, Kawasaki, Kanagawa 210-0821,","place":["Japan"]},{"name":"Department of Anatomy, Keio University School of Medicine , Shinjuku-ku, Tokyo 160-8582,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Central Institute for Experimental Animals , Kawasaki-ku, Kawasaki, Kanagawa 210-0821,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikumi","family":"Katano","sequence":"additional","affiliation":[{"name":"Central Institute for Experimental Animals , Kawasaki-ku, Kawasaki, Kanagawa 210-0821,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kawai","sequence":"additional","affiliation":[{"name":"Central Institute for Experimental Animals , Kawasaki-ku, Kawasaki, Kanagawa 210-0821,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Kamisako","sequence":"additional","affiliation":[{"name":"Central Institute for Experimental Animals , Kawasaki-ku, Kawasaki, Kanagawa 210-0821,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Ogura","sequence":"additional","affiliation":[{"name":"Central Institute for Experimental Animals , Kawasaki-ku, Kawasaki, Kanagawa 210-0821,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Ida-Tanaka","sequence":"additional","affiliation":[{"name":"Central Institute for Experimental Animals , Kawasaki-ku, Kawasaki, Kanagawa 210-0821,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Suemizu","sequence":"additional","affiliation":[{"name":"Central Institute for Experimental Animals , Kawasaki-ku, Kawasaki, Kanagawa 210-0821,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nunomura","sequence":"additional","affiliation":[{"name":"Division of Molecular Cell Immunology and Allergology, Nihon University, Graduate School of Medical Science , Itabashi-ku, Tokyo 173-8610,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisei","family":"Ra","sequence":"additional","affiliation":[{"name":"Division of Molecular Cell Immunology and Allergology, Nihon University, Graduate School of Medical Science , Itabashi-ku, Tokyo 173-8610,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Mori","sequence":"additional","affiliation":[{"name":"National Hospital Organization, Sagamihara National Hospital, Clinical Research Center , Minami-ku, Sagamihara, Kanagawa 252-0315,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadakazu","family":"Aiso","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Keio University School of Medicine , Shinjuku-ku, Tokyo 160-8582,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Ito","sequence":"additional","affiliation":[{"name":"Central Institute for Experimental Animals , Kawasaki-ku, Kawasaki, Kanagawa 210-0821,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,9,15]]},"reference":[{"key":"2025032405375092000_r1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1067\/mai.2000.107194","article-title":"Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC\/Nga mice","volume":"106","author":"Kotani","year":"2000","journal-title":"J. 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