{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:55:26Z","timestamp":1772819726037,"version":"3.50.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Instillation of silica into the lungs of rodents results in pathological changes that strongly mimic human silicosis, an occupational lung disease marked by restrictive airway obstruction, inflammation, and fibrosis. Because IL-13 is a pivotal proinflammatory and fibrogenic cytokine, we examined whether a recombinant immunotoxin comprised of human IL-13 and a mutated form of Pseudomonas exotoxin (IL-13\u2013PE) might affect pathological features of experimental silicosis. Mice received a single intranasal instillation of silica particles and were treated with intranasal IL-13\u2013PE every other day from days 21 to 27 postsilica. The sensitivity of putative cell targets to IL-13\u2013PE was also assessed in in vitro settings. Upregulation of IL-13, its receptor subunits IL-13R\u03b11 and IL-13R\u03b12, and shared receptor IL-4R\u03b1 were associated with development of granulomatous lung inflammation triggered by silica. IL-13\u2013PE inhibited silica-induced granuloma and fibrotic responses noted at 24 h and 15 d after the last treatment. Upregulation of TNF-\u03b1, TGF-\u03b2, and chemokines, as well as increased collagen deposition and airway hyperreactivity to methacholine were all clearly sensitive to IL-13\u2013PE. In addition, IL-13\u2013PE inhibited both IL-13\u2013induced proliferation of cultured lung fibroblasts from silicotic mice and silica-induced IL-8 generation from A549 cells. In conclusion, our findings show that therapeutic treatment with IL-13\u2013PE can reverse important pathological features caused by inhalation of silica particles, suggesting that this recombinant immunotoxin is a promising molecular template in drug discovery for the treatment of silicosis.<\/jats:p>","DOI":"10.4049\/jimmunol.1203551","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T01:21:29Z","timestamp":1381972889000},"page":"5220-5229","source":"Crossref","is-referenced-by-count":32,"title":["IL-13 Immunotoxin Accelerates Resolution of Lung Pathological Changes Triggered by Silica Particles in Mice"],"prefix":"10.1093","volume":"191","author":[{"given":"Tatiana Paula T","family":"Ferreira","sequence":"first","affiliation":[{"name":"Laboratory of Inflammation, Oswaldo Cruz Institute\u2013Oswaldo Cruz Foundation , 21045-900 Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina S","family":"de Arantes","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation, Oswaldo Cruz Institute\u2013Oswaldo Cruz Foundation , 21045-900 Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caio Victor M F","family":"do Nascimento","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation, Oswaldo Cruz Institute\u2013Oswaldo Cruz Foundation , 21045-900 Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla C","family":"Olsen","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation, Oswaldo Cruz Institute\u2013Oswaldo Cruz Foundation , 21045-900 Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia G","family":"Trentin","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation, Oswaldo Cruz Institute\u2013Oswaldo Cruz Foundation , 21045-900 Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia R M","family":"Rocco","sequence":"additional","affiliation":[{"name":"Laboratory of Pulmonary Investigation, Federal University of Rio de Janeiro , 21941-901 Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cory M","family":"Hogaboam","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School , Ann Arbor, MI 48109"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj K","family":"Puri","sequence":"additional","affiliation":[{"name":"Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration , Silver Spring, MD 20993"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Aur\u00e9lio","family":"Martins","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation, Oswaldo Cruz Institute\u2013Oswaldo Cruz Foundation , 21045-900 Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Machado","family":"Rodrigues e Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation, Oswaldo Cruz Institute\u2013Oswaldo Cruz Foundation , 21045-900 Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"key":"2025032405563751600_r1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.disamonth.2007.09.020","article-title":"Silicosis: a review","volume":"53","author":"Greenberg","year":"2007","journal-title":"Dis. 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