{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:50:05Z","timestamp":1793163005231,"version":"4.5.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Development of cerebral malaria (CM), a severe and fatal form of clinical Plasmodium falciparum infection, results from a damaging cascade of vascular, inflammatory, and immunological host responses that leads to brain injury. Progression to CM can be modified by host genetic factors. Our case-control study in Angolan children aimed at highlighting the role of IFN (\u03b1, \u03b2) receptor 1 (IFNAR1) in progression to CM. We report a robust association between IFNAR1 and CM protection, as well as detailed studies showing analogous protection from experimental CM in Ifnar1\u2212\/\u2212 mice infected with P. berghei ANKA. We developed a novel cell-transfer protocol that enables spleen cell priming in the absence of disease. This led to the discovery that IFNAR1 expression in CD8+ T cells is crucial and can abrogate resistance to experimental CM in Ifnar1\u2212\/\u2212 mice. Splenic CD8+ T cells from Ifnar1\u2212\/\u2212 mice are functionally activated upon infection, yet are unable to mediate experimental CM development within the brain tissue. Our findings prove that IFNAR1 signaling unleashes CD8+ T cell effector capacity, which is vital for CM, and raises the hypothesis that the cohesive role of IFNAR1 in both human and mouse CM operates through CD8+ T cell triggering.<\/jats:p>","DOI":"10.4049\/jimmunol.1300114","type":"journal-article","created":{"date-parts":[[2013,4,13]],"date-time":"2013-04-13T03:37:07Z","timestamp":1365824227000},"page":"5118-5127","source":"Crossref","is-referenced-by-count":52,"title":["<i>IFNAR1<\/i> Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in <i>Plasmodium berghei<\/i>\u2013Infected Mice"],"prefix":"10.1093","volume":"190","author":[{"given":"Elizabeth Ann","family":"Ball","sequence":"first","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia , 2781-156 Oeiras,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ros\u00e1rio","family":"Sambo","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia , 2781-156 Oeiras,","place":["Portugal"]},{"name":"Faculdade de Medicina, Universidade Agostinho Neto , Luanda,","place":["Angola"]},{"name":"Hospital Pedi\u00e1trico David Bernardino , Luanda,","place":["Angola"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madalena","family":"Martins","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia , 2781-156 Oeiras,","place":["Portugal"]},{"name":"Neurological Clinical Research Unit, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon , 1649-028 Lisboa,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jesus","family":"Trovoada","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia , 2781-156 Oeiras,","place":["Portugal"]},{"name":"Centro National de Endemias , S\u00e3o Tom\u00e9, Sa\u00f5 Tome e Pr\u00edncipe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Benchimol","sequence":"additional","affiliation":[{"name":"Hospital Pedi\u00e1trico David Bernardino , Luanda,","place":["Angola"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Costa","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia , 2781-156 Oeiras,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edgia","family":"Antunes Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia , 2781-156 Oeiras,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia , 2781-156 Oeiras,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Penha-Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia , 2781-156 Oeiras,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"2025032407001752200_r1","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.4269\/ajtmh.2007.77.1015","article-title":"Differences in presentation of severe malaria in urban and rural Gabon","volume":"77","author":"Issifou","year":"2007","journal-title":"Am. 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