{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:03:32Z","timestamp":1791349412103,"version":"4.3.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Systemic lupus erythematosus is a chronic inflammatory autoimmune disease, the development of which is characterized by a progressive loss of renal function. Such dysfunction is associated with leukocyte infiltration in the glomerular and tubulointerstitial compartments in both human and experimental lupus nephritis. In this study, we investigated the role of the Ccr1 chemokine receptor in this infiltration process during the progression of nephritis in the lupus-prone New Zealand Black\/New Zealand White (NZB\/W) mouse model. We found that peripheral T cells, mononuclear phagocytes, and neutrophils, but not B cells, from nephritic NZB\/W mice were more responsive to Ccr1 ligands than the leukocytes from younger prenephritic NZB\/W mice. Short-term treatment of nephritic NZB\/W mice with the orally available Ccr1 antagonist BL5923 decreased renal infiltration by T cells and macrophages. Longer Ccr1 blockade decreased kidney accumulation of effector\/memory CD4+ T cells, Ly6C+ monocytes, and both M1 and M2 macrophages; reduced tubulointerstitial and glomerular injuries; delayed fatal proteinuria; and prolonged animal lifespan. In contrast, renal humoral immunity was unaffected in BL5923-treated mice, which reflected the unchanged numbers of infiltrated B cells in the kidneys. Altogether, these findings define a pivotal role for Ccr1 in the recruitment of T and mononuclear phagocyte cells to inflamed kidneys of NZB\/W mice, which in turn contribute to the progression of renal injury.<\/jats:p>","DOI":"10.4049\/jimmunol.1300123","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T04:40:10Z","timestamp":1387860010000},"page":"886-896","source":"Crossref","is-referenced-by-count":35,"title":["CCR1 Inhibition Ameliorates the Progression of Lupus Nephritis in NZB\/W Mice"],"prefix":"10.1093","volume":"192","author":[{"given":"Alexandre","family":"Bignon","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Sud, Laboratoire \u201cCytokines, Chimiokines et Immunopathologie,\u201d Unit\u00e9 Mixte de Recherche S996 , 92140 Clamart,","place":["France"]},{"name":"INSERM, Laboratoire d\u2019Excellence en Recherche sur le M\u00e9dicament et l\u2019Innovation Th\u00e9rapeutique , 92140 Clamart,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Gaudin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, Laboratoire \u201cCytokines, Chimiokines et Immunopathologie,\u201d Unit\u00e9 Mixte de Recherche S996 , 92140 Clamart,","place":["France"]},{"name":"INSERM, Laboratoire d\u2019Excellence en Recherche sur le M\u00e9dicament et l\u2019Innovation Th\u00e9rapeutique , 92140 Clamart,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"H\u00e9mon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, Laboratoire \u201cCytokines, Chimiokines et Immunopathologie,\u201d Unit\u00e9 Mixte de Recherche S996 , 92140 Clamart,","place":["France"]},{"name":"INSERM, Laboratoire d\u2019Excellence en Recherche sur le M\u00e9dicament et l\u2019Innovation Th\u00e9rapeutique , 92140 Clamart,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Tharinger","sequence":"additional","affiliation":[{"name":"Institut Paris-Sud d\u2019Innovation Th\u00e9rapeutique\/Institut F\u00e9d\u00e9ratif de Recherche 141 , 92290 Ch\u00e2tenay-Malabry,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Mayol","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, INSERM U1111, Ecole Normale Sup\u00e9rieure, Universit\u00e9 Lyon 1, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 5308 , 69365 Lyon Cedex 07,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Walzer","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, INSERM U1111, Ecole Normale Sup\u00e9rieure, Universit\u00e9 Lyon 1, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 5308 , 69365 Lyon Cedex 07,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pius","family":"Loetscher","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research , Novartis Pharma AG, CH-4056 Basel,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Peuchmaur","sequence":"additional","affiliation":[{"name":"Service d\u2019Anatomie et de Cytologie Pathologique, Unit\u00e9 Propre de Recherche de l\u2019Enseignement Sup\u00e9rieur Associ\u00e9 1320, H\u00f4pital Robert Debr\u00e9 , 75019 Paris,","place":["France"]},{"name":"Universit\u00e9 Denis Diderot, Universit\u00e9 Paris 7 , 75013 Paris","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Berrebi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, Laboratoire \u201cCytokines, Chimiokines et Immunopathologie,\u201d Unit\u00e9 Mixte de Recherche S996 , 92140 Clamart,","place":["France"]},{"name":"INSERM, Laboratoire d\u2019Excellence en Recherche sur le M\u00e9dicament et l\u2019Innovation Th\u00e9rapeutique , 92140 Clamart,","place":["France"]},{"name":"Service d\u2019Anatomie et de Cytologie Pathologique, Unit\u00e9 Propre de Recherche de l\u2019Enseignement Sup\u00e9rieur Associ\u00e9 1320, H\u00f4pital Robert Debr\u00e9 , 75019 Paris,","place":["France"]},{"name":"Universit\u00e9 Denis Diderot, Universit\u00e9 Paris 7 , 75013 Paris","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Balabanian","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, Laboratoire \u201cCytokines, Chimiokines et Immunopathologie,\u201d Unit\u00e9 Mixte de Recherche S996 , 92140 Clamart,","place":["France"]},{"name":"INSERM, Laboratoire d\u2019Excellence en Recherche sur le M\u00e9dicament et l\u2019Innovation 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