{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T14:58:18Z","timestamp":1773500298857,"version":"3.50.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Potassium channels modulate macrophage physiology. Blockade of voltage-dependent potassium channels (Kv) by specific antagonists decreases macrophage cytokine production and inhibits proliferation. In the presence of aspirin, acetylated cyclooxygenase-2 loses the activity required to synthesize PGs but maintains the oxygenase activity to produce 15R-HETE from arachidonate. This intermediate product is transformed via 5-LOX into epimeric lipoxins, termed 15-epi-lipoxins (15-epi-lipoxin A4 [e-LXA4]). Kv have been proposed as anti-inflammatory targets. Therefore, we studied the effects of e-LXA4 on signaling and on Kv and inward rectifier potassium channels (Kir) in mice bone marrow\u2013derived macrophages (BMDM). Electrophysiological recordings were performed in these cells by the whole-cell patch-clamp technique. Treatment of BMDM with e-LXA4 inhibited LPS-dependent activation of NF-\u03baB and I\u03baB kinase \u03b2 activity, protected against LPS activation\u2013dependent apoptosis, and enhanced the accumulation of the Nrf-2 transcription factor. Moreover, treatment of LPS-stimulated BMDM with e-LXA4 resulted in a rapid decrease of Kv currents, compatible with attenuation of the inflammatory response. Long-term treatment of LPS-stimulated BMDM with e-LXA4 significantly reverted LPS effects on Kv and Kir currents. Under these conditions, e-LXA4 decreased the calcium influx versus that observed in LPS-stimulated BMDM. These effects were partially mediated via the lipoxin receptor (ALX), because they were significantly reverted by a selective ALX receptor antagonist. We provide evidence for a new mechanism by which e-LXA4 contributes to inflammation resolution, consisting of the reversion of LPS effects on Kv and Kir currents in macrophages.<\/jats:p>","DOI":"10.4049\/jimmunol.1300235","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T04:49:09Z","timestamp":1384836549000},"page":"6136-6146","source":"Crossref","is-referenced-by-count":38,"title":["Modulation of Voltage-Dependent and Inward Rectifier Potassium Channels by 15-Epi-Lipoxin-A4 in Activated Murine Macrophages: Implications in Innate Immunity"],"prefix":"10.1093","volume":"191","author":[{"given":"Cristina","family":"Moreno","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cientificas, Universidad Aut\u00f3noma de Madrid , 28029 Madrid,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Prieto","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cientificas, Universidad Aut\u00f3noma de Madrid , 28029 Madrid,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Mac\u00edas","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cientificas, Universidad Aut\u00f3noma de Madrid , 28029 Madrid,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Pimentel-Santillana","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cientificas, Universidad Aut\u00f3noma de Madrid , 28029 Madrid,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"de la Cruz","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cientificas, Universidad Aut\u00f3noma de Madrid , 28029 Madrid,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paqui G","family":"Trav\u00e9s","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cientificas, Universidad Aut\u00f3noma de Madrid , 28029 Madrid,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisardo","family":"Bosc\u00e1","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cientificas, Universidad Aut\u00f3noma de Madrid , 28029 Madrid,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas , 08036 Barcelona,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cientificas, Universidad Aut\u00f3noma de Madrid , 28029 Madrid,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,12,15]]},"reference":[{"key":"2025032406063975300_r1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"2025032406063975300_r2","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1002\/eji.200737638","article-title":"The macrophage: past, present and future","volume":"37","author":"Gordon","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"2025032406063975300_r3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/0-387-24180-9_2","article-title":"Toll-like receptors: linking innate and adaptive immunity","volume":"560","author":"Pasare","year":"2005","journal-title":"Adv. Exp. Med. Biol."},{"key":"2025032406063975300_r4","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"2025032406063975300_r5","doi-asserted-by":"crossref","first-page":"46307","DOI":"10.1074\/jbc.M304388200","article-title":"Differential voltage-dependent K+ channel responses during proliferation and activation in macrophages","volume":"278","author":"Vicente","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2025032406063975300_r6","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0958-1669(97)80130-9","article-title":"Ion channels in the immune system as targets for immunosuppression","volume":"8","author":"Cahalan","year":"1997","journal-title":"Curr. Opin. Biotechnol."},{"key":"2025032406063975300_r7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.it.2004.09.002","article-title":"Looking through ion channels: recharged concepts in T-cell signaling","volume":"25","author":"Panyi","year":"2004","journal-title":"Trends Immunol."},{"key":"2025032406063975300_r8","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1161\/ATVBAHA.108.180497","article-title":"Macrophage diversity and polarization in atherosclerosis: a question of balance","volume":"29","author":"Mantovani","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025032406063975300_r9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-immunol-030409-101305","article-title":"An integrated view of humoral innate immunity: pentraxins as a paradigm","volume":"28","author":"Bottazzi","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"2025032406063975300_r10","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4049\/jimmunol.0901698","article-title":"Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation","volume":"185","author":"Rodr\u00edguez-Prados","year":"2010","journal-title":"J. Immunol."},{"key":"2025032406063975300_r11","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1084\/jem.187.8.1285","article-title":"Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release","volume":"187","author":"Gronert","year":"1998","journal-title":"J. Exp. Med."},{"key":"2025032406063975300_r12","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/nm.2538","article-title":"Atherosclerosis: current pathogenesis and therapeutic options","volume":"17","author":"Weber","year":"2011","journal-title":"Nat. Med."},{"key":"2025032406063975300_r13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/eurheartj\/ehr460","article-title":"High-sensitivity C-reactive protein, statin therapy, and risks of atrial fibrillation: an exploratory analysis of the JUPITER trial","volume":"33","author":"Pe\u00f1a","year":"2012","journal-title":"Eur. Heart J."},{"key":"2025032406063975300_r14","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1161\/CIRCRESAHA.112.270132","article-title":"Activation of natural killer T cells ameliorates postinfarct cardiac remodeling and failure in mice","volume":"111","author":"Sobirin","year":"2012","journal-title":"Circ. Res."},{"key":"2025032406063975300_r15","doi-asserted-by":"crossref","first-page":"37675","DOI":"10.1074\/jbc.M605617200","article-title":"Association of Kv1.5 and Kv1.3 contributes to the major voltage-dependent K+ channel in macrophages","volume":"281","author":"Vicente","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2025032406063975300_r16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1085\/jgp.200910334","article-title":"Immunomodulation of voltage-dependent K+ channels in macrophages: molecular and biophysical consequences","volume":"135","author":"Villalonga","year":"2010","journal-title":"J. Gen. Physiol."},{"key":"2025032406063975300_r17","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1084\/jem.20080767","article-title":"Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death","volume":"205","author":"Chen","year":"2008","journal-title":"J. Exp. Med."},{"key":"2025032406063975300_r18","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.tins.2011.08.005","article-title":"Emerging roles of resolvins in the resolution of inflammation and pain","volume":"34","author":"Ji","year":"2011","journal-title":"Trends Neurosci."},{"key":"2025032406063975300_r19","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1096\/fj.11-201442","article-title":"Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain","volume":"26","author":"Serhan","year":"2012","journal-title":"FASEB J."},{"key":"2025032406063975300_r20","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bbalip.2010.08.002","article-title":"Specialized pro-resolving lipid mediators in the inflammatory response: An update","volume":"1801","author":"Bannenberg","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"2025032406063975300_r21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.pathmechdis.3.121806.151409","article-title":"Anti-inflammatory and proresolving lipid mediators","volume":"3","author":"Serhan","year":"2008","journal-title":"Annu. Rev. Pathol."},{"key":"2025032406063975300_r22","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/cdd.2009.220","article-title":"Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K\/Akt and the ERK\/Nrf-2 defense pathways","volume":"17","author":"Prieto","year":"2010","journal-title":"Cell Death Differ."},{"key":"2025032406063975300_r23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"Serhan","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"2025032406063975300_r24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.plefa.2005.05.003","article-title":"Anti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALX","volume":"73","author":"Chiang","year":"2005","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"2025032406063975300_r25","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1096\/fj.02-0770com","article-title":"Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defense","volume":"17","author":"Devchand","year":"2003","journal-title":"FASEB J."},{"key":"2025032406063975300_r26","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1182\/blood-2013-04-496661","article-title":"A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation","volume":"122","author":"Brancaleone","year":"2013","journal-title":"Blood"},{"key":"2025032406063975300_r27","doi-asserted-by":"crossref","first-page":"21416","DOI":"10.1074\/jbc.M111.328278","article-title":"PKC activity regulates functional effects of KVb1.3 on KV1.5 channels. Identification of a cardiac KV1.5 channelosome","volume":"287","author":"David","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2025032406063975300_r28","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/sj.cdd.4401017","article-title":"Induction of apoptosis by nitric oxide in macrophages is independent of apoptotic volume decrease","volume":"9","author":"Hortelano","year":"2002","journal-title":"Cell Death Differ."},{"key":"2025032406063975300_r29","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.4049\/jimmunol.1203029","article-title":"Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses","volume":"190","author":"Trav\u00e9s","year":"2013","journal-title":"J. Immunol."},{"key":"2025032406063975300_r30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/abio.1999.4287","article-title":"Assay for IkappaB kinases using an in vivo biotinylated IkappaB protein substrate","volume":"274","author":"Wisniewski","year":"1999","journal-title":"Anal. Biochem."},{"key":"2025032406063975300_r31","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1124\/mol.106.031906","article-title":"Selective activation of liver X receptors by acanthoic acid-related diterpenes","volume":"71","author":"Traves","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"2025032406063975300_r32","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1085\/jgp.93.4.609","article-title":"Divalent ion trapping inside potassium channels of human T lymphocytes","volume":"93","author":"Grissmer","year":"1989","journal-title":"J. Gen. Physiol."},{"key":"2025032406063975300_r33","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1124\/pr.57.4.10","article-title":"International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels","volume":"57","author":"Gutman","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"2025032406063975300_r34","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1096\/fj.10-159913","article-title":"FPR2\/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis","volume":"24","author":"Maderna","year":"2010","journal-title":"FASEB J."},{"key":"2025032406063975300_r35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.plefa.2005.05.004","article-title":"Taking insult from injury: lipoxins and lipoxin receptor agonists and phagocytosis of apoptotic cells","volume":"73","author":"Maderna","year":"2005","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"2025032406063975300_r36","doi-asserted-by":"crossref","first-page":"8533","DOI":"10.4049\/jimmunol.179.12.8533","article-title":"The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in mice","volume":"179","author":"Souza","year":"2007","journal-title":"J. Immunol."},{"key":"2025032406063975300_r37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/039463200401700103","article-title":"Lipoxin A4 counteracts synergistic activation of human fibroblast-like synoviocytes","volume":"17","author":"Sodin-Semrl","year":"2004","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"2025032406063975300_r38","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tips.2004.03.010","article-title":"K+ channels as targets for specific immunomodulation","volume":"25","author":"Chandy","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"2025032406063975300_r39","doi-asserted-by":"crossref","first-page":"936","DOI":"10.4049\/jimmunol.166.2.936","article-title":"Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation","volume":"166","author":"Beeton","year":"2001","journal-title":"J. Immunol."},{"key":"2025032406063975300_r40","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1124\/mol.104.008193","article-title":"Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases","volume":"67","author":"Beeton","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"2025032406063975300_r41","doi-asserted-by":"crossref","first-page":"13942","DOI":"10.1073\/pnas.241497298","article-title":"Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis","volume":"98","author":"Beeton","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032406063975300_r42","doi-asserted-by":"crossref","first-page":"11094","DOI":"10.1073\/pnas.0501770102","article-title":"The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain","volume":"102","author":"Rus","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032406063975300_r43","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s002329900093","article-title":"Ion channel expression in PMA-differentiated human THP-1 macrophages","volume":"152","author":"DeCoursey","year":"1996","journal-title":"J. Membr. Biol."},{"key":"2025032406063975300_r44","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0006-3495(84)84080-1","article-title":"Calcium- and voltage-activated potassium channels in human macrophages","volume":"46","author":"Gallin","year":"1984","journal-title":"Biophys. J."},{"key":"2025032406063975300_r45","doi-asserted-by":"crossref","first-page":"10680","DOI":"10.1523\/JNEUROSCI.19-24-10680.1999","article-title":"A Kv1.5 to Kv1.3 switch in endogenous hippocampal microglia and a role in proliferation","volume":"19","author":"Kotecha","year":"1999","journal-title":"J. Neurosci."},{"key":"2025032406063975300_r46","doi-asserted-by":"crossref","first-page":"C1123","DOI":"10.1152\/ajpcell.2000.279.4.C1123","article-title":"Upregulation of Kv1.3 K(+) channels in microglia deactivated by TGF-beta","volume":"279","author":"Schilling","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2025032406063975300_r47","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1073\/pnas.81.10.3083","article-title":"Development of a delayed outward-rectifying K+ conductance in cultured mouse peritoneal macrophages","volume":"81","author":"Ypey","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032406063975300_r48","doi-asserted-by":"crossref","first-page":"L862","DOI":"10.1152\/ajplung.00095.2003","article-title":"Kv1.3 potassium channels in human alveolar macrophages","volume":"285","author":"Mackenzie","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2025032406063975300_r49","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.4049\/jimmunol.166.2.1009","article-title":"New insights into endotoxin-induced activation of macrophages: involvement of a K+ channel in transmembrane signaling","volume":"166","author":"Blunck","year":"2001","journal-title":"J. Immunol."},{"key":"2025032406063975300_r50","doi-asserted-by":"crossref","first-page":"C796","DOI":"10.1152\/ajpcell.2001.280.4.C796","article-title":"K+ channels and the microglial respiratory burst","volume":"280","author":"Khanna","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2025032406063975300_r51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","article-title":"The versatility and universality of calcium signalling","volume":"1","author":"Berridge","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025032406063975300_r52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-065X.2009.00816.x","article-title":"The functional network of ion channels in T lymphocytes","volume":"231","author":"Cahalan","year":"2009","journal-title":"Immunol. Rev."},{"key":"2025032406063975300_r53","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature04702","article-title":"A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function","volume":"441","author":"Feske","year":"2006","journal-title":"Nature"},{"key":"2025032406063975300_r54","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature05122","article-title":"Orai1 is an essential pore subunit of the CRAC channel","volume":"443","author":"Prakriya","year":"2006","journal-title":"Nature"},{"key":"2025032406063975300_r55","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.1127883","article-title":"CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry","volume":"312","author":"Vig","year":"2006","journal-title":"Science"},{"key":"2025032406063975300_r56","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature05108","article-title":"Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai","volume":"443","author":"Yeromin","year":"2006","journal-title":"Nature"},{"key":"2025032406063975300_r57","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1084\/jem.177.3.637","article-title":"Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation","volume":"177","author":"Lin","year":"1993","journal-title":"J. Exp. Med."},{"key":"2025032406063975300_r58","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00424-003-1148-2","article-title":"Effect of dexamethasone on voltage-gated K+ channels in Jurkat T-lymphocytes","volume":"447","author":"Lampert","year":"2003","journal-title":"Pflugers Arch."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/191\/12\/6136\/61537017\/1300235.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/191\/12\/6136\/61537017\/1300235.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T18:30:46Z","timestamp":1742927446000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/191\/12\/6136\/7966614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1300235","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,12]]},"published":{"date-parts":[[2013,12]]}}}