{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:57:34Z","timestamp":1790873854837,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Current models of CD4+ T cell help suggest a major role for CD154 binding to CD40 expressed on dendritic cells, with a lesser role for direct T:T interactions via CD40 expressed on CD8+ T cells. However, the contribution of CD8+ T cell\u2013derived CD40 signals during the donor-reactive T cell response to a transplant has never been studied. In this study, we examined the graft-rejection kinetics and CD4+ and CD8+ donor-reactive T cell responses under conditions in which CD40 was genetically ablated only on APC, as well as under conditions in which CD40 was genetically ablated only on donor-reactive CD8+ T cells. Our results revealed a significant role for CD8+ T cell\u2013expressed CD40 in the augmentation of donor-reactive CD8+ T cell responses following transplantation and showed that CD40 expressed on CD8+ T cells must be inhibited to allow conversion of CD4+ T cells into induced regulatory T cells. Thus, this study identifies a major role for CD8+ T cell\u2013derived CD40 signals as a critical switch factor that both promotes optimal differentiation of cytokine-producing CD8+ effector T cell responses and inhibits the differentiation of Ag-specific Foxp3+ induced regulatory T cells in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.1300267","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T04:56:05Z","timestamp":1373950565000},"page":"1957-1964","source":"Crossref","is-referenced-by-count":22,"title":["Inhibition of CD8+ T Cell\u2013Derived CD40 Signals Is Necessary but Not Sufficient for Foxp3+ Induced Regulatory T Cell Generation In Vivo"],"prefix":"10.1093","volume":"191","author":[{"given":"Danya","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Surgery, Emory University, Atlanta, GA 30322; and Emory Transplant Center, Emory University , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana R","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Emory University, Atlanta, GA 30322; and Emory Transplant Center, Emory University , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Konomos","sequence":"additional","affiliation":[{"name":"Department of Surgery, Emory University, Atlanta, GA 30322; and Emory Transplant Center, Emory University , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy L","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Surgery, Emory University, Atlanta, GA 30322; and Emory Transplant Center, Emory University , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,8,15]]},"reference":[{"key":"2025032405190023500_r1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/30996","article-title":"Help for cytotoxic-T-cell responses is mediated by CD40 signalling","volume":"393","author":"Bennett","year":"1998","journal-title":"Nature"},{"key":"2025032405190023500_r2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/31002","article-title":"T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions","volume":"393","author":"Schoenberger","year":"1998","journal-title":"Nature"},{"key":"2025032405190023500_r3","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/30989","article-title":"A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell","volume":"393","author":"Ridge","year":"1998","journal-title":"Nature"},{"key":"2025032405190023500_r4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.immunol.22.012703.104533","article-title":"CD40\/CD154 interactions at the interface of tolerance and immunity","volume":"22","author":"Quezada","year":"2004","journal-title":"Annu. 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