{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:28:58Z","timestamp":1791091738621,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Critical roles of IL-27 in autoimmune diseases and infections have been reported; however, the contribution of endogenous IL-27 to tumor progression remains elusive. In this study, by using IL-27p28 conditional knockout mice, we demonstrate that IL-27 is critical in protective immune response against methyl-cholanthrene\u2013induced fibrosarcoma and transplanted B16 melanoma, and dendritic cells (DCs) are the primary source. DC-derived IL-27 is required for shaping tumor microenvironment by inducing CXCL-10 expression in myeloid-derived suppressor cells and regulating IL-12 production from DCs, which lead to the recruitment and activation of NK and NKT cells resulting in immunological control of tumors. Indeed, reconstitution of IL-27 or CXCL-10 in tumor site significantly inhibits tumor growth and restores the number and activation of NK and NKT cells. In summary, our study identifies a previous unknown critical role of DC-derived IL-27 in NK and NKT cell\u2013dependent antitumor immunity through shaping tumor microenvironment, and sheds light on developing novel therapeutic approaches based on IL-27.<\/jats:p>","DOI":"10.4049\/jimmunol.1300328","type":"journal-article","created":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T01:55:51Z","timestamp":1370310951000},"page":"500-508","source":"Crossref","is-referenced-by-count":55,"title":["Critical Role of Dendritic Cell\u2013Derived IL-27 in Antitumor Immunity through Regulating the Recruitment and Activation of NK and NKT Cells"],"prefix":"10.1093","volume":"191","author":[{"given":"Jun","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University , Tianjin 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