{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:47:33Z","timestamp":1784008053374,"version":"3.55.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In vitro studies identified Y-box\u2013binding protein (YB)-1 as a key regulator of inflammatory mediators. In this study, we observed increased levels of secreted YB-1 in sera from sepsis patients. This led us to investigate the in vivo role of YB-1 in murine models of acute peritonitis following LPS injection, in sterile renal inflammation following unilateral ureteral obstruction, and in experimental pyelonephritis. LPS injection enhanced de novo secretion of YB-1 into the urine and the peritoneal fluid of LPS-treated mice. Furthermore, we could demonstrate a significant, transient upregulation and posttranslational modification (phosphorylation at serine 102) of YB-1 in renal and inflammatory cells. Increased renal cytoplasmic YB-1 amounts conferred enhanced expression of proinflammatory chemokines CCL2 and CCL5. Along these lines, heterozygous YB-1 knockout mice (YB-1+\/d) that display 50% reduced YB-1 levels developed significantly lower responses to both LPS and sterile inflammation induced by unilateral ureteral obstruction. This included diminished immune cell numbers due to impaired migration propensities and reduced chemokine expression. YB-1+\/d mice were protected from LPS-associated mortality (20% mortality on day 3 versus 80% in wild-type controls); however, immunosuppression in YB-1+\/d animals resulted in 50% mortality. In conclusion, our findings identify YB-1 as a major, nonredundant mediator in both systemic and local inflammatory responses.<\/jats:p>","DOI":"10.4049\/jimmunol.1300416","type":"journal-article","created":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T04:36:47Z","timestamp":1374295007000},"page":"2604-2613","source":"Crossref","is-referenced-by-count":64,"title":["YB-1 Is an Early and Central Mediator of Bacterial and Sterile Inflammation In Vivo"],"prefix":"10.1093","volume":"191","author":[{"given":"Lydia","family":"Hanssen","sequence":"first","affiliation":[{"name":"Division of Nephrology and Clinical Immunology, University Hospital Rheinisch-Westfaelische Technische Hochschule-Aachen , 52057 Aachen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Alidousty","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Clinical Immunology, University Hospital Rheinisch-Westfaelische Technische 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Aachen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Boor","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Clinical Immunology, University Hospital Rheinisch-Westfaelische Technische Hochschule-Aachen , 52057 Aachen,","place":["Germany"]},{"name":"Institute of Pathology, University Hospital Rheinisch-Westfaelische Technische Hochschule-Aachen , 52057 Aachen,","place":["Germany"]},{"name":"Institute of Molecular Biomedicine, Comenius University , 81806 Bratislava,","place":["Slovakia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R","family":"Mertens","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hypertension, Diabetes, and Endocrinology, Otto-von-Guericke-University , 39106 Magdeburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia R","family":"van Roeyen","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Clinical Immunology, University Hospital Rheinisch-Westfaelische Technische Hochschule-Aachen , 52057 Aachen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Tacke","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Rheinisch-Westfaelische Technische Hochschule-Aachen , 52057 Aachen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Heymann","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Rheinisch-Westfaelische Technische Hochschule-Aachen , 52057 Aachen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre P","family":"Tittel","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine and Experimental Immunology, Rheinische Friedrich Wilhelms 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