{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:12:12Z","timestamp":1791321132202,"version":"4.3.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Inhibition of B cells constitutes a rational approach for treating B cell\u2013mediated disorders. We demonstrate in this article that the engagement of the surface Ig-like transcript 2 (ILT2) inhibitory receptor with its preferential ligand HLA-G is critical to inhibit B cell functions. Indeed, ILT2\u2013HLA-G interaction impedes both naive and memory B cell functions in vitro and in vivo. Particularly, HLA-G inhibits B cell proliferation, differentiation, and Ig secretion in both T cell\u2013dependent and \u2013independent models of B cell activation. HLA-G mediates phenotypic and functional downregulation of CXCR4 and CXCR5 chemokine receptors on germinal center B cells. In-depth analysis of the molecular mechanisms mediated by ILT2\u2013HLA-G interaction showed a G0\/G1 cell cycle arrest through dephosphorylation of AKT, GSK-3\u03b2, c-Raf, and Foxo proteins. Crucially, we provide in vivo evidence that HLA-G acts as a negative B cell regulator in modulating B cell Ab secretion in a xenograft mouse model. This B cell regulatory mechanism involving ILT2\u2013HLA-G interaction brings important insight to design future B cell\u2013targeted therapies aimed at reducing inappropriate immune reaction in allotransplantation and autoimmune diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1300438","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T04:55:34Z","timestamp":1390452934000},"page":"1536-1546","source":"Crossref","is-referenced-by-count":159,"title":["Binding of HLA-G to ITIM-Bearing Ig-like Transcript 2 Receptor Suppresses B Cell Responses"],"prefix":"10.1093","volume":"192","author":[{"given":"Abderrahim","family":"Naji","sequence":"first","affiliation":[{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux \u00c9nergies Alternatives, Institut des Maladies Emergentes et des Therapies Innovantes, Service de Recherche en Hemato-Immunologie, Hopital Saint-Louis , 75010 Paris,","place":["France"]},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, L\u2019Institut Universitaire d\u2019H\u00e9matologie, Hopital Saint-Louis, Unit\u00e9 Mixte de Recherche E5 , 75010 Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Menier","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux \u00c9nergies Alternatives, Institut des Maladies Emergentes et des Therapies Innovantes, Service de Recherche en Hemato-Immunologie, Hopital Saint-Louis , 75010 Paris,","place":["France"]},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, L\u2019Institut Universitaire d\u2019H\u00e9matologie, Hopital Saint-Louis, Unit\u00e9 Mixte de Recherche E5 , 75010 Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Morandi","sequence":"additional","affiliation":[{"name":"Laboratory of Oncology, G. Gaslini Children\u2019s Hospital , 16147 Genoa,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Agaugu\u00e9","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux \u00c9nergies Alternatives, Institut des Maladies Emergentes et des Therapies Innovantes, Service de Recherche en Hemato-Immunologie, Hopital Saint-Louis , 75010 Paris,","place":["France"]},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, L\u2019Institut Universitaire d\u2019H\u00e9matologie, Hopital Saint-Louis, Unit\u00e9 Mixte de Recherche E5 , 75010 Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guitta","family":"Maki","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux \u00c9nergies Alternatives, Institut des Maladies Emergentes et des Therapies Innovantes, Service de Recherche en Hemato-Immunologie, Hopital Saint-Louis , 75010 Paris,","place":["France"]},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, L\u2019Institut Universitaire d\u2019H\u00e9matologie, Hopital Saint-Louis, Unit\u00e9 Mixte de Recherche E5 , 75010 Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Ferretti","sequence":"additional","affiliation":[{"name":"Laboratory of Oncology, G. Gaslini Children\u2019s Hospital , 16147 Genoa,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Bruel","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux \u00c9nergies Alternatives, Institut des Maladies Emergentes et des Therapies Innovantes, Service de Recherche en Hemato-Immunologie, Hopital Saint-Louis , 75010 Paris,","place":["France"]},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, L\u2019Institut Universitaire d\u2019H\u00e9matologie, Hopital Saint-Louis, Unit\u00e9 Mixte de Recherche E5 , 75010 Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Pistoia","sequence":"additional","affiliation":[{"name":"Laboratory of Oncology, G. 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