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We found that the expression of wild-type p53-induced phosphatase 1 (Wip1) in mouse and human neutrophils was downregulated quickly after neutrophil activation through JNK-microRNA-16 pathway. Importantly, the Wip1 expression level was negatively correlated with inflammatory cytokine productions of neutrophils in sepsis patients. Wip1-deficient mice displayed increased bactericidal activities to Staphylococcus aureus and were hypersensitive to LPS-induced acute lung damage with increased neutrophil infiltration and inflammation. Mechanism studies showed that the enhanced inflammatory activity of neutrophils caused by Wip1 deficiency was mediated by p38 MAPK-STAT1 and NF-\u03baB pathways. The increased migration ability of Wip1KO neutrophils was mediated by the decreased CXCR2 internalization and desensitization, which was directly regulated by p38 MAPK activity. Thus, our findings identify a previously unrecognized function of Wip1 as an intrinsic negative regulator for neutrophil proinflammatory cytokine production and migration through multiple signal pathways.<\/jats:p>","DOI":"10.4049\/jimmunol.1300656","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T04:18:05Z","timestamp":1389068285000},"page":"1184-1195","source":"Crossref","is-referenced-by-count":66,"title":["Phosphatase Wip1 Negatively Regulates Neutrophil Migration and Inflammation"],"prefix":"10.1093","volume":"192","author":[{"given":"Bo","family":"Sun","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine , Beijing 100700,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongran","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Science and Peking Union Medical College , Beijing 100021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,1]]},"reference":[{"key":"2025032404092703800_r1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1749-6632.1999.tb08473.x","article-title":"Stem cells, pre-progenitor cells and lineage-committed cells: are our dogmas correct?","volume":"872","author":"Metcalf","year":"1999","journal-title":"Ann. 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Chem."},{"key":"2025032404092703800_r42","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1182\/blood.V89.9.3421","article-title":"Activation of the NF-\u03baB pathway by inflammatory stimuli in human neutrophils","volume":"89","author":"McDonald","year":"1997","journal-title":"Blood"},{"key":"2025032404092703800_r43","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1189\/jlb.0806536","article-title":"Differential involvement of NF-\u03baB and MAP kinase pathways in the generation of inflammatory cytokines by human neutrophils","volume":"81","author":"Cloutier","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"2025032404092703800_r44","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s12010-012-9958-3","article-title":"Identifying the regulative role of NF-\u03baB binding sites within promoter region of human matrix metalloproteinase 9 (mmp-9) by TNF-\u03b1 induction","volume":"169","author":"Wu","year":"2013","journal-title":"Appl. Biochem. 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Lipid Res."},{"key":"2025032404092703800_r52","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.4049\/jimmunol.158.3.1361","article-title":"Chemoattractant cross-desensitization of the human neutrophil IL-8 receptor involves receptor internalization and differential receptor subtype regulation","volume":"158","author":"Sabroe","year":"1997","journal-title":"J. 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