{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:21:09Z","timestamp":1791217269890,"version":"4.1.0"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CD4+ T follicular helper cells (TFH) are critical for the formation and function of B cell responses to infection or immunization, but also play an important role in autoimmunity. The factors that contribute to the differentiation of this helper cell subset are incompletely understood, although several cytokines including IL-6, IL-21, and IL-12 can promote TFH cell formation. Yet, none of these factors, nor their downstream cognate STATs, have emerged as nonredundant, essential drivers of TFH cells. This suggests a model in which multiple factors can contribute to the phenotypic characteristics of TFH cells. Because type I IFNs are often generated in immune responses, we set out to investigate whether these factors are relevant to TFH cell differentiation. Type I IFNs promote Th1 responses, thus one possibility was these factors antagonized TFH-expressed genes. However, we show that type I IFNs (IFN-\u03b1\/\u03b2) induced B cell lymphoma 6 (Bcl6) expression, the master regulator transcription factor for TFH cells, and CXCR5 and programmed cell death-1 (encoded by Pdcd1), key surface molecules expressed by TFH cells. In contrast, type I IFNs failed to induce IL-21, the signature cytokine for TFH cells. The induction of Bcl6 was regulated directly by STAT1, which bound to the Bcl6, Cxcr5, and Pdcd1 loci. These data suggest that type I IFNs (IFN-\u03b1\/\u03b2) and STAT1 can contribute to some features of TFH cells but are inadequate in inducing complete programming of this subset.<\/jats:p>","DOI":"10.4049\/jimmunol.1300675","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T21:39:30Z","timestamp":1391204370000},"page":"2156-2166","source":"Crossref","is-referenced-by-count":121,"title":["Type I IFN Induces Binding of STAT1 to Bcl6: Divergent Roles of STAT Family Transcription Factors in the T Follicular Helper Cell Genetic Program"],"prefix":"10.1093","volume":"192","author":[{"given":"Shingo","family":"Nakayamada","sequence":"first","affiliation":[{"name":"Lymphocyte Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda C","family":"Poholek","sequence":"additional","affiliation":[{"name":"Lymphocyte Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina T","family":"Lu","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Lymphocyte Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanari","family":"Kato","sequence":"additional","affiliation":[{"name":"Lymphocyte Biology 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Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Kanno","sequence":"additional","affiliation":[{"name":"Lymphocyte Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"O\u2019Shea","sequence":"additional","affiliation":[{"name":"Lymphocyte Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,3,1]]},"reference":[{"key":"2025032404151670200_r1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/383787a0","article-title":"Functional diversity of helper T lymphocytes","volume":"383","author":"Abbas","year":"1996","journal-title":"Nature"},{"key":"2025032404151670200_r2","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/2081332a0","article-title":"Thymus and the production of antibody-plaque-forming cells","volume":"208","author":"Miller","year":"1965","journal-title":"Nature"},{"key":"2025032404151670200_r3","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.3181\/00379727-118-30073","article-title":"Absence of antibody plaque forming cells in spleens of thymectomized mice immunized with sheep erythrocytes","volume":"118","author":"Friedman","year":"1965","journal-title":"Proc. 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Immunol."},{"key":"2025032404151670200_r44","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.8140422","article-title":"Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6","volume":"264","author":"Zhong","year":"1994","journal-title":"Science"},{"key":"2025032404151670200_r45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.167.1.1","article-title":"Cutting edge: the common \u03b3-chain is an indispensable subunit of the IL-21 receptor complex","volume":"167","author":"Asao","year":"2001","journal-title":"J. Immunol."},{"key":"2025032404151670200_r46","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1182\/blood-2011-11-392985","article-title":"Functional STAT3 deficiency compromises the generation of human T follicular helper cells","volume":"119","author":"Ma","year":"2012","journal-title":"Blood"},{"key":"2025032404151670200_r47","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.immuni.2009.04.016","article-title":"Human dendritic cells induce the differentiation of interleukin-21\u2011producing T follicular helper-like cells through interleukin-12","volume":"31","author":"Schmitt","year":"2009","journal-title":"Immunity"},{"key":"2025032404151670200_r48","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1182\/blood-2012-08-448902","article-title":"IL-12 receptor \u03b21 deficiency alters in vivo T follicular helper cell response in humans","volume":"121","author":"Schmitt","year":"2013","journal-title":"Blood"},{"key":"2025032404151670200_r49","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.immuni.2011.11.012","article-title":"Early Th1 cell differentiation is marked by a Tfh cell-like transition","volume":"35","author":"Nakayamada","year":"2011","journal-title":"Immunity"},{"key":"2025032404151670200_r50","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/ni.2242","article-title":"Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile","volume":"13","author":"Oestreich","year":"2012","journal-title":"Nat. Immunol."},{"key":"2025032404151670200_r51","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1084\/jem.20111174","article-title":"STAT5 is a potent negative regulator of TFH cell differentiation","volume":"209","author":"Johnston","year":"2012","journal-title":"J. Exp. Med."},{"key":"2025032404151670200_r52","doi-asserted-by":"crossref","first-page":"11234","DOI":"10.1074\/jbc.M111.324046","article-title":"STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function","volume":"287","author":"Nurieva","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2025032404151670200_r53","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2012.02.012","article-title":"Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation","volume":"36","author":"Ballesteros-Tato","year":"2012","journal-title":"Immunity"},{"key":"2025032404151670200_r54","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2567.2011.03412.x","article-title":"Regulation of effector and memory T-cell functions by type I interferon","volume":"132","author":"Huber","year":"2011","journal-title":"Immunology"},{"key":"2025032404151670200_r55","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1126\/science.1237568","article-title":"Immunology: an interferon paradox","volume":"340","author":"Odorizzi","year":"2013","journal-title":"Science"},{"key":"2025032404151670200_r56","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1126\/science.1235214","article-title":"Persistent LCMV infection is controlled by blockade of type I interferon signaling","volume":"340","author":"Teijaro","year":"2013","journal-title":"Science"},{"key":"2025032404151670200_r57","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1126\/science.1235208","article-title":"Blockade of chronic type I interferon signaling to control persistent LCMV infection","volume":"340","author":"Wilson","year":"2013","journal-title":"Science"},{"key":"2025032404151670200_r58","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.4049\/jimmunol.157.11.4781","article-title":"Activation of STAT4 by IL-12 and IFN-\u03b1: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation","volume":"157","author":"Cho","year":"1996","journal-title":"J. Immunol."},{"key":"2025032404151670200_r59","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1074\/jbc.275.4.2693","article-title":"Recruitment of Stat4 to the human interferon-\u03b1\/\u03b2 receptor requires activated Stat2","volume":"275","author":"Farrar","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2025032404151670200_r60","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1002\/eji.200324829","article-title":"Frontline: absence of functional STAT4 activation despite detectable tyrosine phosphorylation induced by murine IFN-\u03b1","volume":"34","author":"Berenson","year":"2004","journal-title":"Eur. J. 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Med."},{"key":"2025032404151670200_r78","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/intimm\/8.5.765","article-title":"Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes","volume":"8","author":"Agata","year":"1996","journal-title":"Int. Immunol."},{"key":"2025032404151670200_r79","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/ni1488","article-title":"IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways","volume":"8","author":"Zhou","year":"2007","journal-title":"Nat. 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