{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T21:56:39Z","timestamp":1765230999926,"version":"3.40.3"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Stomatococcus mucilaginosus is an oral commensal that has been occasionally reported to cause severe infections in immunocompromised patients. There is no information about the pathogenic role of S. mucilaginosus in airway infections. In a cohort of 182 subjects with bronchiectasis, we found that 9% were colonized with S. mucilaginosus in their lower airways by culture growth from bronchoalveolar lavage. To address the pathogenic potential of S.mucilaginosus, we developed a murine model of S. mucilaginosus lung infection. Intratracheal injection of S. mucilaginosus in C57BL\/6 mice resulted in a neutrophilic influx with production of proinflammatory cytokines, chemokines, and lipid mediators, mainly PGE2 with induction of cyclooxygenase-2 (COX-2) in the lungs. Presence of TLR2 was necessary for induction of COX-2 and production of PGE2 by S. mucilaginosus. TLR2-deficient mice showed an enhanced clearance of S. mucilaginosus compared with wild-type mice. Administration of PGE2 to TLR2\u2212\/\u2212 mice resulted in impaired clearance of S. mucilaginosus, suggesting a key role for COX-2\u2013induced PGE2 production in immune response to S. mucilaginosus. Mechanistically, induction of COX-2 in macrophages was dependent on the p38-ERK\/MAPK signaling pathway. Furthermore, mice treated with S. mucilaginosus and Pseudomonas aeruginosa showed an increased mortality compared with mice treated with PA103 or S. mucilaginosus alone. Inhibition of COX-2 significantly improved survival in mice infected with PA103 and S. mucilaginosus. These data provide novel insights into the bacteriology and personalized microbiome in patients with bronchiectasis and suggest a pathogenic role for S. mucilaginosus in patients with bronchiectasis.<\/jats:p>","DOI":"10.4049\/jimmunol.1300883","type":"journal-article","created":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T01:33:03Z","timestamp":1378776783000},"page":"3810-3817","source":"Crossref","is-referenced-by-count":19,"title":["Induction of Cyclooxygenase-2 Signaling by <i>Stomatococcus mucilaginosus<\/i> Highlights the Pathogenic Potential of an Oral Commensal"],"prefix":"10.1093","volume":"191","author":[{"given":"Zhihong","family":"Yuan","sequence":"first","affiliation":[{"name":"Veterans Affairs Medical Center , Gainesville, FL 32610"},{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida , Gainesville, FL 32610"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipti","family":"Panchal","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center , Gainesville, FL 32610"},{"name":"Section of Pulmonary, Critical Care, and Sleep Medicine, University of Illinois , Chicago, IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansoor Ali","family":"Syed","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center , Gainesville, FL 32610"},{"name":"Section of Pulmonary, Critical Care, and Sleep Medicine, University of Illinois , Chicago, IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiren","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida , Gainesville, FL 32610"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myungsoo","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Pusan University , Yangsan 626-870,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walid","family":"Hadid","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center , Gainesville, FL 32610"},{"name":"Section of Pulmonary, Critical Care, and Sleep Medicine, University of Illinois , Chicago, IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruxana T","family":"Sadikot","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center , Gainesville, FL 32610"},{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida , Gainesville, FL 32610"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"2025032405422647100_r1","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJMra012519","article-title":"Bronchiectasis","volume":"346","author":"Barker","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"2025032405422647100_r2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccm.2012.02.004","article-title":"Pathogenesis of bronchiectasis","volume":"33","author":"Moulton","year":"2012","journal-title":"Clin. Chest Med."},{"key":"2025032405422647100_r3","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1510\/icvts.2011.284208","article-title":"Non-cystic fibrosis bronchiectasis","volume":"13","author":"Neves","year":"2011","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"2025032405422647100_r4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.phrs.2012.11.006","article-title":"The oral microbiome in health and disease","volume":"69","author":"Wade","year":"2013","journal-title":"Pharmacol. Res."},{"key":"2025032405422647100_r5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev-genom-090711-163814","article-title":"The human microbiome: our second genome","volume":"13","author":"Grice","year":"2012","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"2025032405422647100_r6","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1046\/j.1469-0691.2003.00772.x","article-title":"Bacteremia due to Stomatococcus mucilaginosus in neutropenic patients in the setting of a cancer institute","volume":"9","author":"Fanourgiakis","year":"2003","journal-title":"Clin. Microbiol. Infect."},{"key":"2025032405422647100_r7","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1469-0691.1999.tb00116.x","article-title":"Pneumonia due to Stomatococcus mucilaginosus in an AIDS patient: case report and literature review","volume":"5","author":"Lambotte","year":"1999","journal-title":"Clin. Microbiol. Infect."},{"key":"2025032405422647100_r8","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1179\/joc.2000.12.6.536","article-title":"Treatment of Stomatococcus mucilaginosus bloodstream infection in two acute leukemia patients, first reported at our cancer center","volume":"12","author":"Paci","year":"2000","journal-title":"J. Chemother."},{"key":"2025032405422647100_r9","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00007611-199103000-00029","article-title":"Stomatococcus mucilaginosus catheter-related infection in an adolescent with osteosarcoma","volume":"84","author":"Ascher","year":"1991","journal-title":"South. Med. J."},{"key":"2025032405422647100_r10","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1093\/clinids\/13.6.1048","article-title":"Infections due to Stomatococcus mucilaginosus: 10 cases and review","volume":"13","author":"Ascher","year":"1991","journal-title":"Rev. Infect. Dis."},{"key":"2025032405422647100_r11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1198-743X(14)65140-5","article-title":"Stomatococcus mucilaginosus septicemia in leukemic patients","volume":"2","author":"Granlund","year":"1996","journal-title":"Clin. Microbiol. Infect."},{"key":"2025032405422647100_r12","first-page":"678","article-title":"Stomatococcus mucilaginosus infections in children with leukemia","volume":"9","author":"Weinblatt","year":"1990","journal-title":"Pediatr. Infect. Dis. J."},{"key":"2025032405422647100_r13","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/BF02148699","article-title":"Stomatococcus mucilaginosus endocarditis","volume":"4","author":"Prag","year":"1985","journal-title":"Eur. J. Clin. Microbiol."},{"key":"2025032405422647100_r14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1128\/jcm.27.1.215-216.1989","article-title":"Endocarditis caused by relatively penicillin-resistant Stomatococcus mucilaginosus","volume":"27","author":"Pinsky","year":"1989","journal-title":"J. Clin. Microbiol."},{"key":"2025032405422647100_r15","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1128\/jcm.27.5.1125-1126.1989","article-title":"Stomatococcus mucilaginosus catheter-associated infection with septicemia","volume":"27","author":"Poirier","year":"1989","journal-title":"J. Clin. Microbiol."},{"key":"2025032405422647100_r16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0163-4453(94)91312-9","article-title":"Stomatococcus mucilaginosus lower respiratory tract infection in a patient with AIDS","volume":"29","author":"Cunniffe","year":"1994","journal-title":"J. Infect."},{"key":"2025032405422647100_r17","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1080\/00365540701387064","article-title":"Eight cases of lower respiratory tract infection caused by Stomatococcus mucilaginosus","volume":"39","author":"Korsholm","year":"2007","journal-title":"Scand. J. Infect. Dis."},{"key":"2025032405422647100_r18","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1164\/rccm.200408-1044SO","article-title":"Pathogen-host interactions in Pseudomonas aeruginosa pneumonia","volume":"171","author":"Sadikot","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025032405422647100_r19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"2025032405422647100_r20","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","article-title":"Toll-like receptors and their crosstalk with other innate receptors in infection and immunity","volume":"34","author":"Kawai","year":"2011","journal-title":"Immunity"},{"key":"2025032405422647100_r21","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/eji.200636636","article-title":"Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2","volume":"37","author":"Sadikot","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"2025032405422647100_r22","doi-asserted-by":"crossref","first-page":"8222","DOI":"10.4049\/jimmunol.180.12.8222","article-title":"Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii","volume":"180","author":"Aronoff","year":"2008","journal-title":"J. Immunol."},{"key":"2025032405422647100_r23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.prostaglandins.2012.03.002","article-title":"E-prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae","volume":"98","author":"Aronoff","year":"2012","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"2025032405422647100_r24","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.4049\/jimmunol.0801795","article-title":"Histoplasma capsulatum cell wall beta-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection","volume":"182","author":"Sorgi","year":"2009","journal-title":"J. Immunol."},{"key":"2025032405422647100_r25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1574-695X.2010.00656.x","article-title":"Cyclooxygenase-derived mediators regulate the immunological control of Strongyloides venezuelensis infection","volume":"59","author":"Machado","year":"2010","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"2025032405422647100_r26","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1165\/rcmb.2007-0153OC","article-title":"Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidase","volume":"37","author":"Serezani","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2025032405422647100_r27","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.4049\/jimmunol.0900129","article-title":"E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection","volume":"183","author":"Aronoff","year":"2009","journal-title":"J. Immunol."},{"key":"2025032405422647100_r28","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1182\/blood-2011-08-374207","article-title":"Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2\/protein kinase A signaling","volume":"119","author":"Zaslona","year":"2012","journal-title":"Blood"},{"key":"2025032405422647100_r29","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1084\/jem.20082058","article-title":"Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2\/EP2 signaling","volume":"206","author":"Medeiros","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025032405422647100_r30","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.4049\/jimmunol.179.4.2565","article-title":"Induction and function of lipocalin prostaglandin D synthase in host immunity","volume":"179","author":"Joo","year":"2007","journal-title":"J. Immunol."},{"key":"2025032405422647100_r31","doi-asserted-by":"crossref","first-page":"503128","DOI":"10.1155\/2012\/503128","article-title":"PGD synthase and PGD2 in immune response","volume":"2012","author":"Joo","year":"2012","journal-title":"Mediators Inflamm."},{"key":"2025032405422647100_r32","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1164\/ajrccm.164.5.2008059","article-title":"High-dose dexamethasone accentuates nuclear factor-kappa B activation in endotoxin-treated mice","volume":"164","author":"Sadikot","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025032405422647100_r33","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.4049\/jimmunol.172.3.1801","article-title":"p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia","volume":"172","author":"Sadikot","year":"2004","journal-title":"J. Immunol."},{"key":"2025032405422647100_r34","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.4049\/jimmunol.176.8.4923","article-title":"Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa","volume":"176","author":"Sadikot","year":"2006","journal-title":"J. Immunol."},{"key":"2025032405422647100_r35","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.antiviral.2011.07.011","article-title":"Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro","volume":"91","author":"Lee","year":"2011","journal-title":"Antiviral Res."},{"key":"2025032405422647100_r36","doi-asserted-by":"crossref","first-page":"7811","DOI":"10.4049\/jimmunol.177.11.7811","article-title":"Cyclooxygenase-2 inhibition attenuates antibody responses against human papillomavirus-like particles","volume":"177","author":"Ryan","year":"2006","journal-title":"J. Immunol."},{"key":"2025032405422647100_r37","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.4049\/jimmunol.177.4.2391","article-title":"Cyclooxygenase-2 inhibitor enhances the efficacy of a breast cancer vaccine: role of IDO","volume":"177","author":"Basu","year":"2006","journal-title":"J. Immunol."},{"key":"2025032405422647100_r38","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1111\/j.1462-5822.2007.00902.x","article-title":"Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaB-inhibiting activity","volume":"9","author":"Mazur","year":"2007","journal-title":"Cell. Microbiol."},{"key":"2025032405422647100_r39","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/157488712799363280","article-title":"Use of antibiotics in bronchiectasis","volume":"7","author":"King","year":"2012","journal-title":"Rev. Recent Clin. Trials"},{"key":"2025032405422647100_r40","doi-asserted-by":"crossref","first-page":"L668","DOI":"10.1152\/ajplung.00043.2007","article-title":"Regulation of cyclooxygenase-2 expression by small GTPase Rac2 in bone marrow macrophages","volume":"293","author":"Azim","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2025032405422647100_r41","doi-asserted-by":"crossref","first-page":"7868","DOI":"10.4049\/jimmunol.179.11.7868","article-title":"NF-kappaB-inducing kinase regulates cyclooxygenase 2 gene expression in macrophages by phosphorylation of PU.1","volume":"179","author":"Azim","year":"2007","journal-title":"J. Immunol."},{"key":"2025032405422647100_r42","doi-asserted-by":"crossref","first-page":"8111","DOI":"10.4049\/jimmunol.177.11.8111","article-title":"Cyclooxygenase-2 gene transcription in a macrophage model of inflammation","volume":"177","author":"Kang","year":"2006","journal-title":"J. Immunol."},{"key":"2025032405422647100_r43","doi-asserted-by":"crossref","first-page":"L1219","DOI":"10.1152\/ajplung.00474.2006","article-title":"Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages","volume":"292","author":"Joo","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2025032405422647100_r44","doi-asserted-by":"crossref","first-page":"55127","DOI":"10.1074\/jbc.M409885200","article-title":"Toll-like receptor 2 and mitogen- and stress-activated kinase 1 are effectors of Mycobacterium avium-induced cyclooxygenase-2 expression in macrophages","volume":"279","author":"Pathak","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2025032405422647100_r45","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2174\/156802607779941314","article-title":"Eicosanoids in inflammation: biosynthesis, pharmacology, and therapeutic frontiers","volume":"7","author":"Khanapure","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"2025032405422647100_r46","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.4049\/jimmunol.171.6.3047","article-title":"Candida albicans induces selectively transcriptional activation of cyclooxygenase-2 in HeLa cells: pivotal roles of Toll-like receptors, p38 mitogen-activated protein kinase, and NF-kappa B","volume":"171","author":"Deva","year":"2003","journal-title":"J. Immunol."},{"key":"2025032405422647100_r47","doi-asserted-by":"crossref","first-page":"6234","DOI":"10.1128\/IAI.71.11.6234-6242.2003","article-title":"Role of cyclooxygenase enzymes in a murine model of experimental cholera","volume":"71","author":"Gessell-Lee","year":"2003","journal-title":"Infect. Immun."},{"key":"2025032405422647100_r48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1158\/1940-6207.CAPR-11-0496","article-title":"The effect of HIV and HPV coinfection on cervical COX-2 expression and systemic prostaglandin E2 levels","volume":"5","author":"Fitzgerald","year":"2012","journal-title":"Cancer Prev. Res."},{"key":"2025032405422647100_r49","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.virol.2012.03.019","article-title":"Production of prostaglandin E2 in response to infection with modified vaccinia Ankara virus","volume":"428","author":"Pollara","year":"2012","journal-title":"Virology"},{"key":"2025032405422647100_r50","first-page":"850","article-title":"Alteration in heme oxygenase-1 and nitric oxide synthase-2 gene expression during endotoxemia in cyclooxygenase-2-deficient mice","volume":"6","author":"Ejima","year":"2004","journal-title":"Antioxid. Redox Signal."},{"key":"2025032405422647100_r51","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.4049\/jimmunol.1101186","article-title":"Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis","volume":"187","author":"Fredenburgh","year":"2011","journal-title":"J. Immunol."},{"key":"2025032405422647100_r52","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1128\/IAI.72.3.1637-1644.2004","article-title":"Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis","volume":"72","author":"Medeiros","year":"2004","journal-title":"Infect. Immun."},{"key":"2025032405422647100_r53","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.4049\/jimmunol.177.8.5499","article-title":"Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation","volume":"177","author":"Ballinger","year":"2006","journal-title":"J. Immunol."},{"key":"2025032405422647100_r54","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/SHK.0b013e318272ff8a","article-title":"Ketoprofen impairs immunosuppression induced by severe sepsis and reveals an important role for prostaglandin E2","volume":"38","author":"Brogliato","year":"2012","journal-title":"Shock"},{"key":"2025032405422647100_r55","doi-asserted-by":"crossref","first-page":"37937","DOI":"10.1074\/jbc.M305108200","article-title":"Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2","volume":"278","author":"Murakami","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2025032405422647100_r56","doi-asserted-by":"crossref","first-page":"e50244","DOI":"10.1371\/journal.pone.0050244","article-title":"Lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 mediates late-phase PGE2 production in bone marrow derived macrophages","volume":"7","author":"Xiao","year":"2012","journal-title":"PLoS One"},{"key":"2025032405422647100_r57","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1136\/thx.2006.060293","article-title":"COX-2: a link between airway inflammation and disordered chloride secretion in cystic fibrosis?","volume":"61","author":"Clayton","year":"2006","journal-title":"Thorax"},{"key":"2025032405422647100_r58","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1136\/thx.2004.039842","article-title":"Upregulation of COX-1 and COX-2 in nasal polyps in cystic fibrosis","volume":"61","author":"Roca-Ferrer","year":"2006","journal-title":"Thorax"},{"key":"2025032405422647100_r59","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1056\/NEJM199503303321303","article-title":"Effect of high-dose ibuprofen in patients with cystic fibrosis","volume":"332","author":"Konstan","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"2025032405422647100_r60","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.molimm.2011.11.011","article-title":"ESAT-6 induced COX-2 expression involves coordinated interplay between PI3K and MAPK signaling","volume":"49","author":"Bansal","year":"2012","journal-title":"Mol. Immunol."},{"key":"2025032405422647100_r61","doi-asserted-by":"crossref","first-page":"a009738","DOI":"10.1101\/cshperspect.a009738","article-title":"The cystic fibrosis airway microbiome","volume":"3","author":"Lynch","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"2025032405422647100_r62","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/MOP.0b013e32834604f2","article-title":"The airway microbiome in cystic fibrosis and implications for treatment","volume":"23","author":"Zemanick","year":"2011","journal-title":"Curr. Opin. Pediatr."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/191\/7\/3810\/62510817\/1300883.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/191\/7\/3810\/62510817\/1300883.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T05:57:34Z","timestamp":1742882254000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/191\/7\/3810\/7989776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,1]]},"references-count":62,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,10,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1300883","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[2013,10]]},"published":{"date-parts":[[2013,10,1]]}}}