{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:29:40Z","timestamp":1791221380304,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CD8 T cell memory critically contributes to long-term immunity. Both low- and high-affinity TCR signals are able to support the differentiation of memory CD8 T cells. However, it is unclear whether the requirements for memory development change when TCR signal strength is altered. To gain further insight into this question, we used a TCR\u03b2 transmembrane domain mutant model that is defective in the generation of memory in response to high-affinity ligands. Surprisingly, lowering TCR signal strength, by stimulation with low-affinity ligands, resulted in normal memory development. Restoration of memory correlated with recovery of TCR-dependent NF-\u03baB signaling. Thus, these data provide novel evidence that the requirements for memory are qualitatively different depending on TCR signal strength.<\/jats:p>","DOI":"10.4049\/jimmunol.1300905","type":"journal-article","created":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T03:43:24Z","timestamp":1384573404000},"page":"5797-5801","source":"Crossref","is-referenced-by-count":23,"title":["Cutting Edge: The Signals for the Generation of T Cell Memory Are Qualitatively Different Depending on TCR Ligand Strength"],"prefix":"10.1093","volume":"191","author":[{"given":"Karin M","family":"Knudson","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri , Columbia, MO 65212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota Medical School , Minneapolis, MN 55454"},{"name":"Center for Immunology, University of Minnesota Medical School , Minneapolis, MN 55454"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri , Columbia, MO 65212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C","family":"Jameson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota Medical School , Minneapolis, MN 55454"},{"name":"Center for Immunology, University of Minnesota Medical School , Minneapolis, MN 55454"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Teixeiro","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri , Columbia, MO 65212"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,12,15]]},"reference":[{"key":"2025032406061979600_r1","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1002\/(SICI)1521-4141(200005)30:5<1458::AID-IMMU1458>3.0.CO;2-2","article-title":"Tracing and characterization of the low-avidity self-specific T cell repertoire","volume":"30","author":"de Visser","year":"2000","journal-title":"Eur. 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