{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:27:44Z","timestamp":1791217664216,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although IFN-\u03b3 is required for resolution of Listeria monocytogenes infection, the identities of the IFN-\u03b3\u2013responsive cells that initiate the process remain unclear. We addressed this question using novel mice with conditional loss of IFN-\u03b3R (IFNGR1). Itgax-cre+Ifngr1f\/f mice with selective IFN-\u03b3 unresponsiveness in CD8\u03b1+ dendritic cells displayed increased susceptibility to infection. This phenotype was due to the inability of IFN-\u03b3\u2013unresponsive CD8\u03b1+ dendritic cells to produce the initial burst of IL-12 induced by IFN-\u03b3 from TNF-\u03b1\u2013activated NK\/NKT cells. The defect in early IL-12 production resulted in increased IL-4 production that established a myeloid cell environment favoring Listeria growth. Neutralization of IL-4 restored Listeria resistance in Itgax-cre+Ifngr1f\/f mice. We also found that Itgax-cre+Ifngr1f\/f mice survived infection with low-dose Listeria as the result of a second wave of IL-12 produced by Ly6Chi monocytes. Thus, an IFN-\u03b3\u2013driven cascade involving CD8\u03b1+ dendritic cells and NK\/NKT cells induces the rapid production of IL-12 that initiates the anti-Listeria response.<\/jats:p>","DOI":"10.4049\/jimmunol.1300910","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T03:44:38Z","timestamp":1379562278000},"page":"4223-4234","source":"Crossref","is-referenced-by-count":71,"title":["Identifying the Initiating Events of Anti-\n                    <i>Listeria<\/i>\n                    Responses Using Mice with Conditional Loss of IFN-\u03b3 Receptor Subunit 1 (IFNGR1)"],"prefix":"10.1093","volume":"191","author":[{"given":"Sang Hun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier A","family":"Carrero","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Uppaluri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Michael","family":"White","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M","family":"Archambault","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koon Siew","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szeman Ruby","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen C F","family":"Sheehan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil R","family":"Unanue","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"2025032405452769000_r1","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nri1461","article-title":"Immune responses to Listeria monocytogenes","volume":"4","author":"Pamer","year":"2004","journal-title":"Nat. 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