{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:35:43Z","timestamp":1791329743679,"version":"4.3.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>NK cells constitute the first line of defense against pathogens and transformed cells. They mature in secondary lymphoid organs, including tonsils, where common pathogens, such as EBV, enter the host and potentially imprint differentiating cells, which then patrol the body via the blood stream. Therefore, we set out to characterize a distinct human NK cell population in tonsils that produces high amounts of the immunomodulatory and antiviral cytokine IFN-\u03b3. We found that the tonsilar IFN-\u03b3high NK cell subset is CD56brightNKG2A+CD94+CD54+CD62L\u2212, is present in tonsils ex vivo and is more mature than other CD56bright NK cells in tonsils and less mature than other NK cells in blood, shows very low plasticity even after prolonged cytokine stimulation, accumulates in tonsils of EBV carriers, and is able to potently restrict EBV-induced transformation of B cells. Thus, we characterized a distinct and stable IFN-\u03b3high NK cell subpopulation that can specifically restrict malignant transformation of EBV-infected B cells. This subset should be exploited for future development of cell-based therapeutic approaches in EBV-associated malignancies.<\/jats:p>","DOI":"10.4049\/jimmunol.1301046","type":"journal-article","created":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T16:24:38Z","timestamp":1381422278000},"page":"4989-4995","source":"Crossref","is-referenced-by-count":71,"title":["A Distinct Subpopulation of Human NK Cells Restricts B Cell Transformation by EBV"],"prefix":"10.1093","volume":"191","author":[{"given":"Anna","family":"L\u00fcnemann","sequence":"first","affiliation":[{"name":"Viral Immunobiology, Institute of Experimental Immunology, University of Z\u00fcrich , CH-8057 Z\u00fcrich,","place":["Switzerland"]},{"name":"Experimental Infectious Diseases and Cancer Research, Division of Infectious Diseases and Hospital Epidemiology, Children\u2019s Research Center, University Children\u2019s Hospital of Z\u00fcrich , CH-8032 Z\u00fcrich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana D","family":"Vanoaica","sequence":"additional","affiliation":[{"name":"Viral Immunobiology, Institute of Experimental Immunology, University of Z\u00fcrich , CH-8057 Z\u00fcrich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik","family":"Azzi","sequence":"additional","affiliation":[{"name":"Experimental Infectious Diseases and Cancer Research, Division of Infectious Diseases and Hospital Epidemiology, Children\u2019s Research Center, University Children\u2019s Hospital of Z\u00fcrich , CH-8032 Z\u00fcrich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Nadal","sequence":"additional","affiliation":[{"name":"Experimental Infectious Diseases and Cancer Research, Division of Infectious Diseases and Hospital Epidemiology, Children\u2019s Research Center, University Children\u2019s Hospital of Z\u00fcrich , CH-8032 Z\u00fcrich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"M\u00fcnz","sequence":"additional","affiliation":[{"name":"Viral Immunobiology, Institute of Experimental Immunology, University of Z\u00fcrich , CH-8057 Z\u00fcrich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"key":"2025032405570600800_r1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/eji.1830050208","article-title":"\u201cNatural\u201d killer cells in the mouse. 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