{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:28:04Z","timestamp":1787030884516,"version":"build-2736575974"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Structural congenital heart disease (CHD) has not previously been linked to autoimmunity. In our study, we developed an autoimmune model of structural CHD that resembles hypoplastic left heart syndrome (HLHS), a life-threatening CHD primarily affecting the left ventricle. Because cardiac myosin (CM) is a dominant autoantigen in autoimmune heart disease, we hypothesized that immunization with CM might lead to transplacental passage of maternal autoantibodies and a prenatal HLHS phenotype in exposed fetuses. Elevated anti-CM autoantibodies in maternal and fetal sera, as well as IgG reactivity in fetal myocardium, were correlated with structural CHD that included diminished left ventricular cavity dimensions in the affected progeny. Further, fetuses that developed a marked HLHS phenotype had elevated serum titers of anti\u2013\u03b2-adrenergic receptor Abs, as well as increased protein kinase A activity, suggesting a potential mechanism for the observed pathological changes. Our maternal\u2013fetal model presents a new concept linking autoimmunity against CM and cardiomyocyte proliferation with cardinal features of HLHS. To our knowledge, this report shows the first evidence in support of a novel immune-mediated mechanism for pathogenesis of structural CHD that may have implications in its future diagnosis and treatment.<\/jats:p>","DOI":"10.4049\/jimmunol.1301264","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:32:59Z","timestamp":1395880379000},"page":"4074-4082","source":"Crossref","is-referenced-by-count":17,"title":["Congenital Heart Disease Linked to Maternal Autoimmunity against Cardiac Myosin"],"prefix":"10.1093","volume":"192","author":[{"given":"Charles R","family":"Cole","sequence":"first","affiliation":[{"name":"Division of Molecular Cardiovascular Biology, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E","family":"Yutzey","sequence":"additional","affiliation":[{"name":"Division of Molecular Cardiovascular Biology, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop K","family":"Brar","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Washington University Medical Center , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa S","family":"Goessling","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Washington University Medical Center , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J","family":"VanVickle-Chavez","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Washington University Medical Center , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine W","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirooz","family":"Eghtesady","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Washington University Medical Center , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"key":"2025032404271613900_r1","first-page":"e2","article-title":"Heart disease and stroke statistics\u20142012 update: a report from the American Heart Association","volume":"125","author":"Roger","year":"2012","journal-title":"Circulation"},{"key":"2025032404271613900_r2","first-page":"e25","article-title":"Heart disease and stroke statistics\u20142008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee","volume":"117","author":"Rosamond","year":"2008","journal-title":"Circulation"},{"key":"2025032404271613900_r3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1017\/S1047951105000132","article-title":"Current issues and perspectives in hypoplasia of the left heart","volume":"15","author":"Sedmera","year":"2005","journal-title":"Cardiol. 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