{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:51:30Z","timestamp":1793238690486,"version":"4.5.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>High-affinity class-switched Abs and memory B cells are products of the germinal center (GC). The CD4+ T cell help required for the development and maintenance of the GC is delivered by follicular Th cells (TFH), a CD4+ Th cell subset characterized by expression of Bcl-6 and secretion of IL-21. The cellular interactions that mediate differentiation of TFH and GC B cells remain an important area of investigation. We previously showed that MHC class II (MHCII)\u2013dependent dendritic cell Ag presentation is sufficient for the differentiation of a TFH intermediate (termed pre-TFH), characterized by Bcl-6 expression but lacking IL-21 secretion. In this article, we examine the contributions of MHCII Ag presentation by B cells to TFH differentiation and GC responses in several contexts. B cells alone do not efficiently prime naive CD4+ T cells or induce TFH after protein immunization; however, during lymphocytic choriomeningitis virus infection, B cells induce TFH differentiation despite the lack of effector CD4+ T cell generation. Still, MHCII+ dendritic cells and B cells cooperate for optimal TFH and GC B cell differentiation in response to both model Ags and viral infection. This study highlights the roles for B cells in both CD4+ T cell priming and TFH differentiation, and demonstrates that different APC subsets work in tandem to mediate the GC response.<\/jats:p>","DOI":"10.4049\/jimmunol.1301284","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T05:23:45Z","timestamp":1395293025000},"page":"3607-3617","source":"Crossref","is-referenced-by-count":127,"title":["B Cell Antigen Presentation in the Initiation of Follicular Helper T Cell and Germinal Center Differentiation"],"prefix":"10.1093","volume":"192","author":[{"given":"Lisa G","family":"Barnett","sequence":"first","affiliation":[{"name":"Department of Medicine, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M A","family":"Simkins","sequence":"additional","affiliation":[{"name":"Department of Medicine, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burton E","family":"Barnett","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa L","family":"Korn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy L","family":"Johnson","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E John","family":"Wherry","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory F","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St. Louis , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri M","family":"Laufer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Philadelphia Veterans Affairs Medical Center , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,4,15]]},"reference":[{"key":"2025032404242028800_r1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"2025032404242028800_r2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/ni.1740","article-title":"MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity","volume":"10","author":"Perrigoue","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025032404242028800_r3","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.4049\/jimmunol.0803180","article-title":"Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation","volume":"182","author":"Kambayashi","year":"2009","journal-title":"J. Immunol."},{"key":"2025032404242028800_r4","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/0168-9525(89)90140-6","article-title":"Fine-tuning of MHC class II gene expression in defined microenvironments","volume":"5","author":"Fehling","year":"1989","journal-title":"Trends Genet."},{"key":"2025032404242028800_r5","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3763::AID-IMMU3763>3.0.CO;2-D","article-title":"CD4+ T cell responses in mice lacking MHC class II molecules specifically on B cells","volume":"28","author":"Williams","year":"1998","journal-title":"Eur. J. 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Immunol."},{"key":"2025032404242028800_r37","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.immuni.2012.11.020","article-title":"Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype","volume":"38","author":"Baumjohann","year":"2013","journal-title":"Immunity"},{"key":"2025032404242028800_r38","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nature03555","article-title":"A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity","volume":"435","author":"Vinuesa","year":"2005","journal-title":"Nature"},{"key":"2025032404242028800_r39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/ni.1690","article-title":"The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells","volume":"10","author":"Bauquet","year":"2009","journal-title":"Nat. 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Exp. Med."},{"key":"2025032404242028800_r44","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<390::AID-IMMU390>3.0.CO;2-O","article-title":"Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection","volume":"28","author":"Oxenius","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"2025032404242028800_r45","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"2025032404242028800_r46","doi-asserted-by":"crossref","first-page":"545","DOI":"10.4049\/jimmunol.1201598","article-title":"Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses","volume":"191","author":"Archambault","year":"2013","journal-title":"J. Immunol."},{"key":"2025032404242028800_r47","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1126\/science.1910207","article-title":"Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice","volume":"253","author":"Grusby","year":"1991","journal-title":"Science"},{"key":"2025032404242028800_r48","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.immuni.2008.08.013","article-title":"Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells","volume":"29","author":"Allenspach","year":"2008","journal-title":"Immunity"},{"key":"2025032404242028800_r49","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1128\/JVI.77.8.4911-4927.2003","article-title":"Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment","volume":"77","author":"Wherry","year":"2003","journal-title":"J. Virol."},{"key":"2025032404242028800_r50","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.1093\/nar\/29.3.e10","article-title":"A method for the generation of conditional gene repair mutations in mice","volume":"29","author":"Dragatsis","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"2025032404242028800_r51","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/nar\/25.6.1317","article-title":"B lymphocyte-specific, Cre-mediated mutagenesis in mice","volume":"25","author":"Rickert","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2025032404242028800_r52","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0092-8674(91)90448-8","article-title":"Mice lacking MHC class II molecules","volume":"66","author":"Cosgrove","year":"1991","journal-title":"Cell"},{"key":"2025032404242028800_r53","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1084\/jem.175.1.131","article-title":"Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens","volume":"175","author":"Eynon","year":"1992","journal-title":"J. Exp. Med."},{"key":"2025032404242028800_r54","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nri2454","article-title":"The who, how and where of antigen presentation to B cells","volume":"9","author":"Batista","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"2025032404242028800_r55","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.4049\/jimmunol.1101328","article-title":"Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells","volume":"187","author":"Wollenberg","year":"2011","journal-title":"J. Immunol."},{"key":"2025032404242028800_r56","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.2426","article-title":"Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions","volume":"17","author":"Chung","year":"2011","journal-title":"Nat. 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Immunol."},{"key":"2025032404242028800_r60","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.4049\/jimmunol.135.5.2937","article-title":"Antigen presentation by splenic B cells: resting B cells are ineffective, whereas activated B cells are effective accessory cells for T cell responses","volume":"135","author":"Krieger","year":"1985","journal-title":"J. Immunol."},{"key":"2025032404242028800_r61","doi-asserted-by":"crossref","first-page":"8252","DOI":"10.1073\/pnas.88.18.8252","article-title":"Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure","volume":"88","author":"Odermatt","year":"1991","journal-title":"Proc. Natl. Acad. Sci. 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