{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:46:41Z","timestamp":1791226001102,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Autoantibodies targeting conformationally intact myelin oligodendrocyte glycoprotein (MOG) are found in different inflammatory diseases of the CNS, but their antigenic epitopes have not been mapped. We expressed mutants of MOG on human HeLa cells and analyzed sera from 111 patients (104 children, 7 adults) who recognized cell-bound human MOG, but had different diseases, including acute disseminated encephalomyelitis (ADEM), one episode of transverse myelitis or optic neuritis, multiple sclerosis (MS), anti-aquaporin-4 (AQP4)\u2013negative neuromyelitis optica (NMO), and chronic relapsing inflammatory optic neuritis (CRION). We obtained insight into the recognition of epitopes in 98 patients. All epitopes identified were located at loops connecting the \u03b2 strands of MOG. The most frequently recognized MOG epitope was revealed by the P42S mutation positioned in the CC\u2032-loop. Overall, we distinguished seven epitope patterns, including the one mainly recognized by mouse mAbs. In half of the patients, the anti-MOG response was directed to a single epitope. The epitope specificity was not linked to certain disease entities. Longitudinal analysis of 11 patients for up to 5 y indicated constant epitope recognition without evidence for intramolecular epitope spreading. Patients who rapidly lost their anti-MOG IgG still generated a long-lasting IgG response to vaccines, indicating that their loss of anti-MOG reactivity did not reflect a general lack of capacity for long-standing IgG responses. The majority of human anti-MOG Abs did not recognize rodent MOG, which has implications for animal studies. Our findings might assist in future detection of potential mimotopes and pave the way to Ag-specific depletion.<\/jats:p>","DOI":"10.4049\/jimmunol.1301296","type":"journal-article","created":{"date-parts":[[2013,9,7]],"date-time":"2013-09-07T03:08:36Z","timestamp":1378523316000},"page":"3594-3604","source":"Crossref","is-referenced-by-count":137,"title":["Distinction and Temporal Stability of Conformational Epitopes on Myelin Oligodendrocyte Glycoprotein Recognized by Patients with Different Inflammatory Central Nervous System Diseases"],"prefix":"10.1093","volume":"191","author":[{"given":"Marie C","family":"Mayer","sequence":"first","affiliation":[{"name":"Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University , 81377 Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanze","family":"Breithaupt","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biotechnology, Martin-Luther-University Halle-Wittenberg , 06120 Halle,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Reindl","sequence":"additional","affiliation":[{"name":"Clinical Department of Neurology, Innsbruck Medical University , 6020 Innsbruck,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Schanda","sequence":"additional","affiliation":[{"name":"Clinical Department of Neurology, Innsbruck Medical University , 6020 Innsbruck,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Rost\u00e1sy","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics, Department of Pediatrics I, Innsbruck Medical University , 6020 Innsbruck,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Berger","sequence":"additional","affiliation":[{"name":"Clinical Department of Neurology, Innsbruck Medical University , 6020 Innsbruck,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell C","family":"Dale","sequence":"additional","affiliation":[{"name":"Neuroimmunology Group, Institute of Neuroscience and Muscle Research, the Kids Research Institute at the Children\u2019s Hospital at Westmead, University of Sydney , Westmead, New South Wales 2145,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Brilot","sequence":"additional","affiliation":[{"name":"Neuroimmunology Group, Institute of Neuroscience and Muscle Research, the Kids Research Institute at the Children\u2019s Hospital at Westmead, University of Sydney , Westmead, New South Wales 2145,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Olsson","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska University Hospital , 17176 Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Jenne","sequence":"additional","affiliation":[{"name":"Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz-Zentrum M\u00fcnchen, Member of the German Center for Lung Research , 81377 Munich,","place":["Germany"]},{"name":"Max Planck Institute of Neurobiology , 82152 Martinsried,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Katrin","family":"Pr\u00f6bstel","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University , 81377 Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Dornmair","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University , 81377 Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Wekerle","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Neurobiology , 82152 Martinsried,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Hohlfeld","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University , 81377 Munich,","place":["Germany"]},{"name":"Munich Cluster for Systems Neurology (SyNergy) , 80336 Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Banwell","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics, The Children\u2019s Hospital of Philadelphia, University of Pennsylvania , PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Bar-Or","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Montreal Neurological Institute, McGill University , Montreal, Quebec H3A 2BA,","place":["Canada"]},{"name":"Experimental Therapeutics Program, Montreal Neurological Institute, McGill University , Montreal, Quebec H3A 2BA,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Meinl","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University , 81377 Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"2025032405401970100_r1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S1474-4422(11)70096-5","article-title":"Autoantibodies associated with diseases of the CNS: new developments and future 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