{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:00:03Z","timestamp":1777615203006,"version":"3.51.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Fc\u03b3RIIB, the only Fc\u03b3R expressed on B cells, is important in the maintenance of immunological tolerance to self-Ags. In this study, we investigated the role of Fc\u03b3RIIB in Ag-specific CD4 T cell tolerance induced by mucosally administered Ag (OVA) coupled to cholera toxin B subunit (Ag\/CTB) or given alone. We found that sublingual administration of Ag\/CTB conjugate or intragastric administration of a &amp;gt;100-fold higher dose of Ag alone efficiently suppressed parenteral immunization\u2013induced Ag-specific T cell proliferation and delayed-type hypersensitivity responses in Fc\u03b3RIIB-expressing wild-type (WT), but not Fc\u03b3RIIB\u2212\/\u2212, mice. Such mucosally induced tolerance (oral tolerance) associated with induction of Ag-specific Foxp3+ regulatory T cells was restored in Fc\u03b3RIIB\u2212\/\u2212 mice by adoptive transfer of either WT B cells or WT dendritic cells before the mucosal Ag\/CTB treatment; it was even more pronounced in \u03bcMT mice that received Fc\u03b3RIIB-overexpressing B cells before treatment. Furthermore, cell transfer in either WT or \u03bcMT mice of WT but not Fc\u03b3RIIB\u2212\/\u2212 B cells pretreated for 1 h in vitro with Ag\/CTB conjugate induced Ag-specific immunological tolerance, which was further enhanced by adoptive transfer of WT B cells pretreated with anti-Ag IgG immune complexed Ag\/CTB. We conclude that Fc\u03b3RIIB expression on B cells, in addition to dendritic cells, is important for mucosal induction of Ag-specific immune tolerance.<\/jats:p>","DOI":"10.4049\/jimmunol.1301324","type":"journal-article","created":{"date-parts":[[2013,9,14]],"date-time":"2013-09-14T04:09:44Z","timestamp":1379131784000},"page":"4412-4422","source":"Crossref","is-referenced-by-count":17,"title":["Important Role for Fc\u03b3RIIB on B Lymphocytes for Mucosal Antigen-Induced Tolerance and Foxp3+ Regulatory T Cells"],"prefix":"10.1093","volume":"191","author":[{"given":"Jia-Bin","family":"Sun","sequence":"first","affiliation":[{"name":"University of Gothenburg Vaccine Institute , SE405 30 G\u00f6teborg,","place":["Sweden"]},{"name":"Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg , SE-405 30 G\u00f6teborg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zou","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg , SE-405 30 G\u00f6teborg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth G C","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cambridge Institute for Medical Research , Cambridge CB2 OXY,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Holmgren","sequence":"additional","affiliation":[{"name":"University of Gothenburg Vaccine Institute , SE405 30 G\u00f6teborg,","place":["Sweden"]},{"name":"Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg , SE-405 30 G\u00f6teborg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"2025032405470678900_r1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-065X.2011.01017.x","article-title":"Oral tolerance","volume":"241","author":"Weiner","year":"2011","journal-title":"Immunol. 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