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To assess the cell-intrinsic role of NIK in murine T cell function, we generated mixed bone marrow chimeras using bone marrow from NIK knockout (KO) and wild-type (WT) donor mice and infected the chimeras with lymphocytic choriomeningitis virus (LCMV). The chimeras possess an apparently normal immune system, including a mixture of NIK KO and WT T cells, and the virus was cleared normally. Comparison of the NIK KO and WT CD4 and CD8 T cell responses at 8 d post infection revealed modest but significant differences in the acute response. In both CD4 and CD8 compartments, relatively fewer activated (CD44hi) NIK KO T cells were present, but within the CD44hi population, a comparable percentage of the activated cells produced IFN-\u03b3 in response to ex vivo stimulation with antigenic LCMV peptides, although IL-7R expression was reduced in the NIK KO CD8 T cells. Assessment of the LCMV-specific memory at 65 d post infection revealed many more LCMV-specific WT memory T cells than NIK KO memory T cells in both the CD4 and the CD8 compartments, although the small number of surviving NIK KO memory T cells responded to secondary challenge with virus. These results demonstrate a cell-intrinsic requirement for NIK in the generation and\/or maintenance of memory T cells in response to acute viral infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1301328","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T04:46:35Z","timestamp":1378356395000},"page":"3663-3672","source":"Crossref","is-referenced-by-count":44,"title":["A Cell-Intrinsic Requirement for NF-\u03baB\u2013Inducing Kinase in CD4 and CD8 T Cell Memory"],"prefix":"10.1093","volume":"191","author":[{"given":"Alexander M","family":"Rowe","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology & Immunology, Oregon Health & Science University , Portland, OR 07239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology & Immunology, Oregon Health & Science University , Portland, OR 07239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Rau\u00e9","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR 97006"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Koguchi","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology & Immunology, Oregon Health & Science University , Portland, OR 07239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K","family":"Slifka","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology & Immunology, Oregon Health & Science University , Portland, OR 07239"},{"name":"Oregon National Primate Research Center, Oregon Health & Science University , Beaverton, OR 97006"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology & Immunology, Oregon Health & Science University , Portland, OR 07239"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"2025032405430139000_r1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.coi.2010.02.013","article-title":"Inflammatory cytokines as a third signal for T cell activation","volume":"22","author":"Curtsinger","year":"2010","journal-title":"Curr. 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