{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T01:29:35Z","timestamp":1779240575059,"version":"3.51.4"},"reference-count":110,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although acquired bone marrow failure (BMF) is considered a T cell\u2013mediated autoimmune disease, possible innate immune defects as a cause for systemic immune deviations in response to otherwise innocuous infections have not been extensively explored. In this regard, we recently demonstrated an important role of type I IFNs in protecting hematopoiesis during systemic stress responses to the opportunistic fungal pathogen Pneumocystis in lymphocyte-deficient mice. Mice deficient in both lymphocytes and type I IFN receptor (IFrag\u2212\/\u2212 mice) develop rapidly progressing BMF due to accelerated bone marrow (BM) cell apoptosis associated with innate immune deviations in the BM in response to Pneumocystis lung infection. However, the communication pathway between lung and BM eliciting the induction of BMF in response to this strictly pulmonary infection has been unclear. In this study, we report that absence of an intact type I IFN system during Pneumocystis lung infection not only causes BMF in lymphocyte-deficient mice but also transient BM stress in lymphocyte-competent mice. This is associated with an exuberant systemic IFN-\u03b3 response. IFN-\u03b3 neutralization prevented Pneumocystis lung infection\u2013induced BM depression in type I IFN receptor\u2013deficient mice and prolonged neutrophil survival time in BM from IFrag\u2212\/\u2212 mice. IL-1\u03b2 and upstream regulators of IFN-\u03b3, IL-12, and IL-18 were also upregulated in lung and serum of IFrag\u2212\/\u2212 mice. In conjunction, there was exuberant inflammasome-mediated caspase-1 activation in pulmonary innate immune cells required for processing of IL-18 and IL-1\u03b2. Thus, absence of type I IFN signaling during Pneumocystis lung infection may result in deregulation of inflammasome-mediated pulmonary immune activation, causing systemic immune deviations triggering BMF in this model.<\/jats:p>","DOI":"10.4049\/jimmunol.1301344","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T22:10:32Z","timestamp":1377295832000},"page":"3884-3895","source":"Crossref","is-referenced-by-count":8,"title":["Modulation of Inflammasome-Mediated Pulmonary Immune Activation by Type I IFNs Protects Bone Marrow Homeostasis during Systemic Responses to\n                    <i>Pneumocystis<\/i>\n                    Lung Infection"],"prefix":"10.1093","volume":"191","author":[{"given":"Steve","family":"Searles","sequence":"first","affiliation":[{"name":"Department of Pathology, University of California School of Medicine , La Jolla, CA 92093"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Gauss","sequence":"additional","affiliation":[{"name":"Montana Veterinary Diagnostic Laboratory , Bozeman, MT 59718"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Wilkison","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, MT 59718"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teri R","family":"Hoyt","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, MT 59718"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Dobrinen","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, MT 59718"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Meissner","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, MT 59718"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"2025032405404081500_r1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1365-2559.2010.03612.x","article-title":"The pathology of bone marrow failure","volume":"57","author":"Leguit","year":"2010","journal-title":"Histopathology"},{"key":"2025032405404081500_r2","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1182\/blood-2006-03-010777","article-title":"Current concepts in the pathophysiology and treatment of aplastic anemia","volume":"108","author":"Young","year":"2006","journal-title":"Blood"},{"key":"2025032405404081500_r3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1182\/asheducation-2004.1.318","article-title":"Marrow failure","volume":"2004","author":"Bagby","year":"2004","journal-title":"Hematology (Am Soc Hematol Educ Program)"},{"key":"2025032405404081500_r4","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1182\/blood-2005-05-2096","article-title":"Enhanced TNF-alpha-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1","volume":"106","author":"Bijangi-Vishehsaraei","year":"2005","journal-title":"Blood"},{"key":"2025032405404081500_r5","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1089\/ars.2008.2129","article-title":"Oxidative stress in Fanconi anemia hematopoiesis and disease progression","volume":"10","author":"Du","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"2025032405404081500_r6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jaut.2012.12.011","article-title":"Cytopenia and autoimmune diseases: a vicious cycle fueled by mTOR dysregulation in hematopoietic stem cells","volume":"41","author":"Zheng","year":"2013","journal-title":"J. Autoimmun."},{"key":"2025032405404081500_r7","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.autrev.2005.04.014","article-title":"Immunodysregulation of HIV disease at bone marrow level","volume":"4","author":"Isgr\u00f2","year":"2005","journal-title":"Autoimmun. Rev."},{"key":"2025032405404081500_r8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1089\/aid.2005.21.51","article-title":"HIV type 1 protease inhibitors enhance bone marrow progenitor cell activity in normal subjects and in HIV type 1-infected patients","volume":"21","author":"Isgr\u00f2","year":"2005","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"2025032405404081500_r9","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1056\/NEJMra032588","article-title":"Pneumocystis pneumonia","volume":"350","author":"Thomas","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"2025032405404081500_r10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1086\/523814","article-title":"Epidemiology and clinical significance of pneumocystis colonization","volume":"197","author":"Morris","year":"2008","journal-title":"J. Infect. Dis."},{"key":"2025032405404081500_r11","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1086\/591701","article-title":"Relationship of pneumocystis antibody response to severity of chronic obstructive pulmonary disease","volume":"47","author":"Morris","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"2025032405404081500_r12","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1378\/chest.121.2.609","article-title":"COPD and osteoporosis","volume":"121","author":"Biskobing","year":"2002","journal-title":"Chest"},{"key":"2025032405404081500_r13","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1084\/jem.172.3.937","article-title":"Requirement for CD4+ cells in resistance to Pneumocystis carinii pneumonia in mice","volume":"172","author":"Harmsen","year":"1990","journal-title":"J. Exp. Med."},{"key":"2025032405404081500_r14","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1172\/JCI114621","article-title":"A new model of Pneumocystis carinii infection in mice selectively depleted of helper T lymphocytes","volume":"85","author":"Shellito","year":"1990","journal-title":"J. Clin. Invest."},{"key":"2025032405404081500_r15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nri2939","article-title":"Immunity to fungal infections","volume":"11","author":"Romani","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"2025032405404081500_r16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.4161\/viru.1.4.11482","article-title":"Fungal pathogen recognition by the NLRP3 inflammasome","volume":"1","author":"Joly","year":"2010","journal-title":"Virulence"},{"key":"2025032405404081500_r17","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.4049\/jimmunol.171.3.1423","article-title":"Clearance of Pneumocystis carinii in mice is dependent on B cells but not on P carinii-specific antibody","volume":"171","author":"Lund","year":"2003","journal-title":"J. Immunol."},{"key":"2025032405404081500_r18","doi-asserted-by":"crossref","first-page":"5462","DOI":"10.4049\/jimmunol.174.9.5462","article-title":"Role of type I IFNs in pulmonary complications of Pneumocystis murina infection","volume":"174","author":"Meissner","year":"2005","journal-title":"J. Immunol."},{"key":"2025032405404081500_r19","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1128\/IAI.01273-10","article-title":"Pneumocystis infection in an immunocompetent host can promote collateral sensitization to respiratory antigens","volume":"79","author":"Swain","year":"2011","journal-title":"Infect. Immun."},{"key":"2025032405404081500_r20","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.4049\/jimmunol.1002558","article-title":"IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina","volume":"186","author":"Nelson","year":"2011","journal-title":"J. Immunol."},{"key":"2025032405404081500_r21","doi-asserted-by":"crossref","first-page":"e1001058","DOI":"10.1371\/journal.ppat.1001058","article-title":"Immune modulation with sulfasalazine attenuates immunopathogenesis but enhances macrophage-mediated fungal clearance during Pneumocystis pneumonia","volume":"6","author":"Wang","year":"2010","journal-title":"PLoS Pathog."},{"key":"2025032405404081500_r22","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1128\/IAI.70.3.1069-1074.2002","article-title":"Passive intranasal monoclonal antibody prophylaxis against murine Pneumocystis carinii pneumonia","volume":"70","author":"Gigliotti","year":"2002","journal-title":"Infect. Immun."},{"key":"2025032405404081500_r23","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.coviro.2011.11.001","article-title":"Induction and function of type I and III interferon in response to viral infection","volume":"1","author":"Levy","year":"2011","journal-title":"Curr Opin Virol"},{"key":"2025032405404081500_r24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.0105-2896.2004.00207.x","article-title":"The role of type I interferons in non-viral infections","volume":"202","author":"Bogdan","year":"2004","journal-title":"Immunol. Rev."},{"key":"2025032405404081500_r25","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.chom.2011.04.007","article-title":"A nonredundant role for plasmacytoid dendritic cells in host defense against the human fungal pathogen Aspergillus fumigatus","volume":"9","author":"Ramirez-Ortiz","year":"2011","journal-title":"Cell Host Microbe"},{"key":"2025032405404081500_r26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"2025032405404081500_r27","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.immuni.2006.08.007","article-title":"Type I interferons in host defense","volume":"25","author":"Stetson","year":"2006","journal-title":"Immunity"},{"key":"2025032405404081500_r28","first-page":"S9-94","article-title":"The role of type I interferons in the differentiation and function of Th1 and Th2 cells","volume":"24","author":"de Waal Malefyt","year":"1997","journal-title":"Semin. Oncol."},{"key":"2025032405404081500_r29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1074-7613(03)00208-5","article-title":"Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6","volume":"19","author":"Jego","year":"2003","journal-title":"Immunity"},{"key":"2025032405404081500_r30","doi-asserted-by":"crossref","first-page":"7047","DOI":"10.4049\/jimmunol.0903273","article-title":"Type I IFN receptor regulates neutrophil functions and innate immunity to Leishmania parasites","volume":"184","author":"Xin","year":"2010","journal-title":"J. Immunol."},{"key":"2025032405404081500_r31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.immuni.2006.08.010","article-title":"Type I interferon in systemic lupus erythematosus and other autoimmune diseases","volume":"25","author":"Banchereau","year":"2006","journal-title":"Immunity"},{"key":"2025032405404081500_r32","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.coi.2006.09.014","article-title":"Systemic lupus erythematosus: all roads lead to type I interferons","volume":"18","author":"Pascual","year":"2006","journal-title":"Curr. Opin. Immunol."},{"key":"2025032405404081500_r33","doi-asserted-by":"crossref","first-page":"6705","DOI":"10.4049\/jimmunol.178.11.6705","article-title":"Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production","volume":"178","author":"Chang","year":"2007","journal-title":"J. Immunol."},{"key":"2025032405404081500_r34","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1172\/JCI33342","article-title":"The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice","volume":"118","author":"Guo","year":"2008","journal-title":"J. Clin. Invest."},{"key":"2025032405404081500_r35","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.4049\/jimmunol.166.9.5530","article-title":"IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells","volume":"166","author":"Levings","year":"2001","journal-title":"J. Immunol."},{"key":"2025032405404081500_r36","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1084\/jem.20051725","article-title":"Twist mediates suppression of inflammation by type I IFNs and Axl","volume":"203","author":"Sharif","year":"2006","journal-title":"J. Exp. Med."},{"key":"2025032405404081500_r37","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.immuni.2011.02.006","article-title":"Type I interferon inhibits interleukin-1 production and inflammasome activation","volume":"34","author":"Guarda","year":"2011","journal-title":"Immunity"},{"key":"2025032405404081500_r38","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1191\/135248506ms1247oa","article-title":"Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis (INCOMIN Trial) II: analysis of MRI responses to treatment and correlation with Nab","volume":"12","author":"Barbero","year":"2006","journal-title":"Mult. Scler."},{"key":"2025032405404081500_r39","first-page":"CD005278","article-title":"Recombinant interferon beta or glatiramer acetate for delaying conversion of the first demyelinating event to multiple sclerosis","volume":"2","author":"Clerico","year":"2008","journal-title":"Cochrane Database Syst. Rev."},{"key":"2025032405404081500_r40","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1212\/01.wnl.0000252724.67789.1e","article-title":"A randomized study of two interferon-beta treatments in relapsing-remitting multiple sclerosis","volume":"67","author":"Durelli","year":"2006","journal-title":"Neurology"},{"key":"2025032405404081500_r41","first-page":"1807","article-title":"An open-labeled, randomized study comparing systemic interferon-alpha-2A and prednisolone enemas in the treatment of left-sided ulcerative colitis","volume":"96","author":"Madsen","year":"2001","journal-title":"Am. J. Gastroenterol."},{"key":"2025032405404081500_r42","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1172\/JCI200524518","article-title":"Illuminating the role of type I IFNs in colitis","volume":"115","author":"Wirtz","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2025032405404081500_r43","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/75068","article-title":"Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo","volume":"6","author":"Atreya","year":"2000","journal-title":"Nat. Med."},{"key":"2025032405404081500_r44","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.immuni.2012.01.011","article-title":"Constitutive type I interferon modulates homeostatic balance through tonic signaling","volume":"36","author":"Gough","year":"2012","journal-title":"Immunity"},{"key":"2025032405404081500_r45","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1200\/JCO.2002.03.052","article-title":"Mechanisms and management of toxicities associated with high-dose interferon alfa-2b therapy","volume":"20","author":"Kirkwood","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"2025032405404081500_r46","first-page":"165","article-title":"Autoimmune thyroiditis and myelosuppression following treatment with interferon-alpha for hepatitis C","volume":"37","author":"Schmitt","year":"1999","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"2025032405404081500_r47","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1189\/jlb.1104690","article-title":"Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2","volume":"78","author":"Sakamoto","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"2025032405404081500_r48","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0065-2776(07)95005-1","article-title":"Osteoimmunology: a view from the bone","volume":"95","author":"David","year":"2007","journal-title":"Adv. Immunol."},{"key":"2025032405404081500_r49","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1600-0765.2005.00814.x","article-title":"Inflammatory bone destruction and osteoimmunology","volume":"40","author":"Takayanagi","year":"2005","journal-title":"J. Periodontal Res."},{"key":"2025032405404081500_r50","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.0105-2896.2005.00333.x","article-title":"Skeletal development, bone remodeling, and hematopoiesis","volume":"208","author":"Aguila","year":"2005","journal-title":"Immunol. Rev."},{"key":"2025032405404081500_r51","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ni1331","article-title":"The hematopoietic stem cell in its place","volume":"7","author":"Adams","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025032405404081500_r52","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nature07815","article-title":"IFNalpha activates dormant haematopoietic stem cells in vivo","volume":"458","author":"Essers","year":"2009","journal-title":"Nature"},{"key":"2025032405404081500_r53","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1189\/jlb.0306154","article-title":"Type I interferon production in HIV-infected patients","volume":"80","author":"Hosmalin","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"2025032405404081500_r54","doi-asserted-by":"crossref","first-page":"9243","DOI":"10.1128\/JVI.00457-11","article-title":"Type I interferon contributes to CD4+ T cell depletion induced by infection with HIV-1 in the human thymus","volume":"85","author":"Sivaraman","year":"2011","journal-title":"J. Virol."},{"key":"2025032405404081500_r55","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1086\/425020","article-title":"Early plasmacytoid dendritic cell changes predict plasma HIV load rebound during primary infection","volume":"190","author":"Pacanowski","year":"2004","journal-title":"J. Infect. Dis."},{"key":"2025032405404081500_r56","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1182\/blood.V98.10.3016","article-title":"Reduced blood CD123+ (lymphoid) and CD11c+ (myeloid) dendritic cell numbers in primary HIV-1 infection","volume":"98","author":"Pacanowski","year":"2001","journal-title":"Blood"},{"key":"2025032405404081500_r57","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.4049\/jimmunol.168.9.4796","article-title":"Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals","volume":"168","author":"Chehimi","year":"2002","journal-title":"J. Immunol."},{"key":"2025032405404081500_r58","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1097\/00002030-200109070-00002","article-title":"Interferon-alpha generation and immune reconstitution during antiretroviral therapy for human immunodeficiency virus infection","volume":"15","author":"Siegal","year":"2001","journal-title":"AIDS"},{"key":"2025032405404081500_r59","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1189\/jlb.0909635","article-title":"Plasmacytoid dendritic cells in HIV infection: striking a delicate balance","volume":"87","author":"Fitzgerald-Bocarsly","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"2025032405404081500_r60","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.4049\/jimmunol.178.10.6604","article-title":"Type I interferon signaling and B cells maintain hemopoiesis during Pneumocystis infection of the lung","volume":"178","author":"Meissner","year":"2007","journal-title":"J. Immunol."},{"key":"2025032405404081500_r61","doi-asserted-by":"crossref","first-page":"5956","DOI":"10.4049\/jimmunol.1003558","article-title":"Prevention of bone marrow cell apoptosis and regulation of hematopoiesis by type I IFNs during systemic responses to pneumocystis lung infection","volume":"186","author":"Taylor","year":"2011","journal-title":"J. Immunol."},{"key":"2025032405404081500_r62","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ajpath.2012.03.023","article-title":"Type 1 IFNs suppress accelerated osteoclastogenesis and prevent loss of bone mass during systemic inflammatory responses to Pneumocystis lung infection","volume":"181","author":"Wilkison","year":"2012","journal-title":"Am. J. Pathol."},{"key":"2025032405404081500_r63","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1128\/IAI.71.11.6213-6221.2003","article-title":"Absence of the macrophage mannose receptor in mice does not increase susceptibility to Pneumocystis carinii infection in vivo","volume":"71","author":"Swain","year":"2003","journal-title":"Infect. Immun."},{"key":"2025032405404081500_r64","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1939-165X.2004.tb00351.x","article-title":"Cytologic evaluation of bone marrow in rats: indications, methods, and normal morphology","volume":"33","author":"Bolliger","year":"2004","journal-title":"Vet. Clin. Pathol."},{"key":"2025032405404081500_r65","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1128\/iai.56.8.1858-1863.1988","article-title":"Role of alveolar macrophages in lipopolysaccharide-induced neutrophil accumulation","volume":"56","author":"Harmsen","year":"1988","journal-title":"Infect. Immun."},{"key":"2025032405404081500_r66","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma: an overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"2025032405404081500_r67","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.immuni.2009.09.002","article-title":"Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases","volume":"31","author":"Hu","year":"2009","journal-title":"Immunity"},{"key":"2025032405404081500_r68","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1182\/blood-2003-01-0114","article-title":"TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro","volume":"102","author":"Dufour","year":"2003","journal-title":"Blood"},{"key":"2025032405404081500_r69","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1182\/blood-2005-05-1884","article-title":"Interferon-gamma-induced gene expression in CD34 cells: identification of pathologic cytokine-specific signature profiles","volume":"107","author":"Zeng","year":"2006","journal-title":"Blood"},{"key":"2025032405404081500_r70","first-page":"792","article-title":"Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 36-1993. A 28-year-old man with AIDS, persistent pancytopenia, and lymphoma","volume-title":"N. Engl. J. Med.","year":"1993"},{"key":"2025032405404081500_r71","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nri2691","article-title":"The IL-1 family: regulators of immunity","volume":"10","author":"Sims","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"2025032405404081500_r72","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S1359-6101(03)00043-1","article-title":"The biology of IL-12: coordinating innate and adaptive immune responses","volume":"14","author":"Watford","year":"2003","journal-title":"Cytokine Growth Factor Rev."},{"key":"2025032405404081500_r73","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.coi.2011.07.005","article-title":"Cross-regulation between the IL-1\u03b2\/IL-18 processing inflammasome and other inflammatory cytokines","volume":"23","author":"Barker","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"2025032405404081500_r74","doi-asserted-by":"crossref","first-page":"e45186","DOI":"10.1371\/journal.pone.0045186","article-title":"Distinct licensing of IL-18 and IL-1\u03b2 secretion in response to NLRP3 inflammasome activation","volume":"7","author":"Schmidt","year":"2012","journal-title":"PLoS ONE"},{"key":"2025032405404081500_r75","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.it.2011.01.003","article-title":"Inflammasome activation and IL-1\u03b2 and IL-18 processing during infection","volume":"32","author":"van de Veerdonk","year":"2011","journal-title":"Trends Immunol."},{"key":"2025032405404081500_r76","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.4049\/jimmunol.175.2.1232","article-title":"Elimination of senescent neutrophils by TNF-related apoptosis-inducing [corrected] ligand","volume":"175","author":"Lum","year":"2005","journal-title":"J. Immunol."},{"key":"2025032405404081500_r77","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1182\/blood-2003-12-4274","article-title":"TNF-related apoptosis-inducing ligand is involved in neutropenia of systemic lupus erythematosus","volume":"104","author":"Matsuyama","year":"2004","journal-title":"Blood"},{"key":"2025032405404081500_r78","first-page":"68","article-title":"Systemic dissemination of Pneumocystis carinii in a patient with acquired immunodeficiency syndrome","volume":"38","author":"Amin","year":"1990","journal-title":"Henry Ford Hosp. Med. J."},{"key":"2025032405404081500_r79","first-page":"420","article-title":"[Bone marrow involvement by Pneumocystis carinii in an AIDS patient]","volume":"17","author":"Corti","year":"1999","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"2025032405404081500_r80","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1189\/jlb.1206753","article-title":"The role of the beta-glucan receptor Dectin-1 in control of fungal infection","volume":"82","author":"Dennehy","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"2025032405404081500_r81","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1165\/rcmb.2004-0300OC","article-title":"Pneumocystis cell wall beta-glucans stimulate alveolar epithelial cell chemokine generation through nuclear factor-kappaB-dependent mechanisms","volume":"32","author":"Evans","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2025032405404081500_r82","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1084\/jem.20030932","article-title":"Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp. muris involves molecular recognition by the Dectin-1 beta-glucan receptor","volume":"198","author":"Steele","year":"2003","journal-title":"J. Exp. Med."},{"key":"2025032405404081500_r83","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1128\/CMR.00001-12","article-title":"The Cryptococcus neoformans capsule: a sword and a shield","volume":"25","author":"O\u2019Meara","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"2025032405404081500_r84","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nature10071","article-title":"Activation of the innate immune receptor Dectin-1 upon formation of a \u2018phagocytic synapse\u2019","volume":"472","author":"Goodridge","year":"2011","journal-title":"Nature"},{"key":"2025032405404081500_r85","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.exphem.2004.08.006","article-title":"A mouse model of lymphocyte infusion-induced bone marrow failure","volume":"32","author":"Bloom","year":"2004","journal-title":"Exp. Hematol."},{"key":"2025032405404081500_r86","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0301-472X(99)00009-0","article-title":"Expression of interferon-gamma by stromal cells inhibits murine long-term repopulating hematopoietic stem cell activity","volume":"27","author":"Yu","year":"1999","journal-title":"Exp. Hematol."},{"key":"2025032405404081500_r87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00320711","article-title":"The function of lymphocytes in normal and suppressed hematopoiesis","volume":"48","author":"Zoumbos","year":"1984","journal-title":"Blut"},{"key":"2025032405404081500_r88","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.1128\/MCB.20.13.4724-4735.2000","article-title":"The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors","volume":"20","author":"Pang","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"2025032405404081500_r89","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0092-8674(00)80047-1","article-title":"SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine","volume":"98","author":"Alexander","year":"1999","journal-title":"Cell"},{"key":"2025032405404081500_r90","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/ni1287","article-title":"Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity","volume":"7","author":"Fenner","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025032405404081500_r91","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.2353\/ajpath.2010.091158","article-title":"Type-I IFN signaling suppresses an excessive IFN-gamma response and thus prevents lung damage and chronic inflammation during Pneumocystis (PC) clearance in CD4 T cell-competent mice","volume":"176","author":"Meissner","year":"2010","journal-title":"Am. J. Pathol."},{"key":"2025032405404081500_r92","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1084\/jem.193.6.661","article-title":"Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis","volume":"193","author":"Smyth","year":"2001","journal-title":"J. Exp. Med."},{"key":"2025032405404081500_r93","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.leukres.2005.09.015","article-title":"A probable role for trail-induced apoptosis in the pathogenesis of marrow failure. Implications from an in vitro model and from marrow of aplastic anemia patients","volume":"30","author":"Kakagianni","year":"2006","journal-title":"Leuk. Res."},{"key":"2025032405404081500_r94","first-page":"3733","article-title":"Interferon-gamma modulates TRAIL-mediated apoptosis in human colon carcinoma cells","volume":"21","author":"Langaas","year":"2001","journal-title":"Anticancer Res."},{"key":"2025032405404081500_r95","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1006\/excr.2000.5073","article-title":"p53-independent upregulation of KILLER\/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma","volume":"262","author":"Meng","year":"2001","journal-title":"Exp. Cell Res."},{"key":"2025032405404081500_r96","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1182\/blood.V96.4.1465","article-title":"Coadministration of interleukin-18 and interleukin-12 induces a fatal inflammatory response in mice: critical role of natural killer cell interferon-gamma production and STAT-mediated signal transduction","volume":"96","author":"Carson","year":"2000","journal-title":"Blood"},{"key":"2025032405404081500_r97","first-page":"234","article-title":"Interleukin 18 induces a synergistic enhancement of interferon gamma production in mixed murine spleen cell-tumor cell cultures: role of endogenous interleukin 12","volume":"24","author":"Micallef","year":"2000","journal-title":"Cancer Detect. Prev."},{"key":"2025032405404081500_r98","first-page":"364","article-title":"Proinflammatory interferon-gamma\u2014inducing monokines (interleukin-12, interleukin-18, interleukin-15)\u2014serum profile in patients with systemic lupus erythematosus","volume":"13","author":"Robak","year":"2002","journal-title":"Eur. Cytokine Netw."},{"key":"2025032405404081500_r99","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1086\/598508","article-title":"Early production of gamma-interferon in clinical malaria: role of interleukin-18 and interleukin-12","volume":"48","author":"Torre","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"2025032405404081500_r100","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-065X.2008.00706.x","article-title":"Interleukin-10: new perspectives on an old cytokine","volume":"226","author":"Mosser","year":"2008","journal-title":"Immunol. Rev."},{"key":"2025032405404081500_r101","first-page":"218","article-title":"Pathways for cytokine secretion","volume":"25","author":"Stanley","year":"2010","journal-title":"Physiology (Bethesda)"},{"key":"2025032405404081500_r102","doi-asserted-by":"crossref","first-page":"285","DOI":"10.4049\/jimmunol.1200861","article-title":"Memory CD4+ T cells are required for optimal NK cell effector functions against the opportunistic fungal pathogen Pneumocystis murina","volume":"190","author":"Kelly","year":"2013","journal-title":"J. Immunol."},{"key":"2025032405404081500_r103","doi-asserted-by":"crossref","first-page":"7540","DOI":"10.4049\/jimmunol.178.12.7540","article-title":"Type I IFN contributes to NK cell homeostasis, activation, and antitumor function","volume":"178","author":"Swann","year":"2007","journal-title":"J. Immunol."},{"key":"2025032405404081500_r104","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1158\/1078-0432.CCR-07-0776","article-title":"Interleukin-12: biological properties and clinical application","volume":"13","author":"Del Vecchio","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"2025032405404081500_r105","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.immuni.2012.08.027","article-title":"NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells","volume":"37","author":"Masters","year":"2012","journal-title":"Immunity"},{"key":"2025032405404081500_r106","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1086\/430931","article-title":"Type I interferon production is profoundly and transiently impaired in primary HIV-1 infection","volume":"192","author":"Kamga","year":"2005","journal-title":"J. Infect. Dis."},{"key":"2025032405404081500_r107","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1182\/blood.V98.4.906","article-title":"Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients","volume":"98","author":"Soumelis","year":"2001","journal-title":"Blood"},{"key":"2025032405404081500_r108","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0198-8859(02)00760-7","article-title":"Natural type 1 interferon producing cells in HIV infection","volume":"63","author":"Soumelis","year":"2002","journal-title":"Hum. Immunol."},{"key":"2025032405404081500_r109","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1086\/339548","article-title":"Opportunistic infections in patients with and patients without Acquired Immunodeficiency Syndrome","volume":"34","author":"Sepkowitz","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"2025032405404081500_r110","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1182\/blood.V91.5.1479","article-title":"The influence of human immunodeficiency virus-1 on hematopoiesis","volume":"91","author":"Moses","year":"1998","journal-title":"Blood"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/191\/7\/3884\/62512173\/1301344.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/191\/7\/3884\/62512173\/1301344.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T01:33:02Z","timestamp":1742866382000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/191\/7\/3884\/7989614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,1]]},"references-count":110,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,10,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1301344","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718085307.793484841","asserted-by":"object"}]},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,10]]},"published":{"date-parts":[[2013,10,1]]}}}