{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T05:23:53Z","timestamp":1783747433361,"version":"3.55.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Th17 cells are a proinflammatory subset of effector T cells that have been implicated in the pathogenesis of asthma. Their production of the cytokine IL-17 is known to induce local recruitment of neutrophils, but the direct impact of IL-17 on the lung epithelium is poorly understood. In this study, we describe a novel mouse model of spontaneous IL-17\u2013driven lung inflammation that exhibits many similarities to asthma in humans. We have found that STAT3 hyperactivity in T lymphocytes causes an expansion of Th17 cells, which home preferentially to the lungs. IL-17 secretion then leads to neutrophil infiltration and lung epithelial changes, in turn leading to a chronic inflammatory state with increased mucus production and decreased lung function. We used this model to investigate the effects of IL-17 activity on airway epithelium and identified CXCL5 and MIP-2 as important factors in neutrophil recruitment. The neutralization of IL-17 greatly reduces pulmonary neutrophilia, underscoring a key role for IL-17 in promoting chronic airway inflammation. These findings emphasize the role of IL-17 in mediating neutrophil-driven pulmonary inflammation and highlight a new mouse model that may be used for the development of novel therapies targeting Th17 cells in asthma and other chronic pulmonary diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1301360","type":"journal-article","created":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T04:15:42Z","timestamp":1377144942000},"page":"3100-3111","source":"Crossref","is-referenced-by-count":91,"title":["T Cell\u2013Derived IL-17 Mediates Epithelial Changes in the Airway and Drives Pulmonary Neutrophilia"],"prefix":"10.1093","volume":"191","author":[{"given":"Laura K","family":"Fogli","sequence":"first","affiliation":[{"name":"Department of Pathology, New York University School of Medicine , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S","family":"Sundrud","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, The Scripps Research Institute , Jupiter, FL 33458"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University School of Medicine , New York, NY 10016"},{"name":"Department of Hematology\/Oncology, New York University School of Medicine , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Bajwa","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University School of Medicine , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Jensen","sequence":"additional","affiliation":[{"name":"Immune Disease Institute , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Derudder","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine , Berlin 13092,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University School of Medicine , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryaline","family":"Coffre","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University School of Medicine , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Uyttenhove","sequence":"additional","affiliation":[{"name":"Ludwig Institute , Brussels 1200,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Van Snick","sequence":"additional","affiliation":[{"name":"Ludwig Institute , Brussels 1200,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schmidt-Supprian","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Biochemistry , Munich 82152,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjana","family":"Rao","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Grunig","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, New York University School of Medicine , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Durbin","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University School of Medicine , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano S","family":"Casola","sequence":"additional","affiliation":[{"name":"The Institute of Molecular Oncology, Italian Foundation for Cancer Research , Milan 20139,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Rajewsky","sequence":"additional","affiliation":[{"name":"Immune Disease Institute , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei B","family":"Koralov","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University School of Medicine , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,9,15]]},"reference":[{"key":"2025032405364224900_r1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1600-065X.2011.01032.x","article-title":"Human asthma phenotypes: from the clinic, to cytokines, and back again","volume":"242","author":"Bhakta","year":"2011","journal-title":"Immunol. 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