{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:23:33Z","timestamp":1792718613276,"version":"4.5.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Invariant NKT (iNKT) cells act at the crossroad between innate and adaptive immunity and are important players in the defense against microbial pathogens. iNKT cells can detect pathogens that trigger innate receptors (e.g., TLRs, Rig-I, Dectin-1) within APCs, with the consequential induction of CD1d-mediated Ag presentation and release of proinflammatory cytokines. We show that the cytosolic peptidoglycan-sensing receptors Nod1 and Nod2 are necessary for optimal IFN-\u03b3 production by iNKT cells, as well as NK cells. In the absence of Nod1 and Nod2, iNKT cells had a blunted IFN-\u03b3 response following infection by Salmonella enterica serovar Typhimurium and Listeria monocytogenes. For Gram-negative bacteria, we reveal a synergy between Nod1\/2 and TLR4 in dendritic cells that potentiates IL-12 production and, ultimately, activates iNKT cells. These findings suggest that multiple innate pathways can cooperate to regulate iNKT cell activation during bacterial infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1301412","type":"journal-article","created":{"date-parts":[[2013,10,26]],"date-time":"2013-10-26T03:38:56Z","timestamp":1382758736000},"page":"5646-5654","source":"Crossref","is-referenced-by-count":36,"title":["Nod1 and Nod2 Enhance TLR-Mediated Invariant NKT Cell Activation during Bacterial Infection"],"prefix":"10.1093","volume":"191","author":[{"given":"Thirumahal","family":"Selvanantham","sequence":"first","affiliation":[{"name":"Department of Immunology, University of Toronto , Toronto, Ontario M5S 1A8,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichole K","family":"Escalante","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Toronto , Toronto, Ontario M5S 1A8,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra","family":"Cruz Tleugabulova","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Toronto , Toronto, Ontario M5S 1A8,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Fi\u00e9v\u00e9","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Toronto , Toronto, Ontario M5S 1A8,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen E","family":"Girardin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto , Toronto, Ontario M5S 1A8,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana J","family":"Philpott","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Toronto , Toronto, Ontario M5S 1A8,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Mallevaey","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Toronto , Toronto, Ontario M5S 1A8,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,12,1]]},"reference":[{"key":"2025032406003175400_r1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.immunol.25.022106.141711","article-title":"The biology of NKT cells","volume":"25","author":"Bendelac","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"2025032406003175400_r2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nri854","article-title":"The unconventional lifestyle of NKT cells","volume":"2","author":"Kronenberg","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2025032406003175400_r3","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.coi.2008.03.018","article-title":"CD1d-restricted iNKT cells, the \u2018Swiss-Army knife\u2019 of the immune system","volume":"20","author":"Matsuda","year":"2008","journal-title":"Curr. Opin. Immunol."},{"key":"2025032406003175400_r4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nri3328","article-title":"Recognition of CD1d-restricted antigens by natural killer T cells","volume":"12","author":"Rossjohn","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"2025032406003175400_r5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1600-065X.2012.01166.x","article-title":"Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells","volume":"250","author":"Girardi","year":"2012","journal-title":"Immunol. Rev."},{"key":"2025032406003175400_r6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2567.2012.03580.x","article-title":"Strategy of lipid recognition by invariant natural killer T cells: \u2018one for all and all for one\u2019","volume":"136","author":"Mallevaey","year":"2012","journal-title":"Immunology"},{"key":"2025032406003175400_r7","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.4049\/jimmunol.175.2.1137","article-title":"Invariant V alpha 14+ NKT cells participate in the early response to enteric Listeria monocytogenes infection","volume":"175","author":"Ranson","year":"2005","journal-title":"J. Immunol."},{"key":"2025032406003175400_r8","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1002\/eji.200324254","article-title":"Critical role of Valpha14+ natural killer T cells in the innate phase of host protection against Streptococcus pneumoniae infection","volume":"33","author":"Kawakami","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"2025032406003175400_r9","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.4049\/jimmunol.181.4.2292","article-title":"Rapid NKT cell responses are self-terminating during the course of microbial infection","volume":"181","author":"Chiba","year":"2008","journal-title":"J. Immunol."},{"key":"2025032406003175400_r10","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.4049\/jimmunol.165.9.4797","article-title":"Cutting edge: CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferi","volume":"165","author":"Kumar","year":"2000","journal-title":"J. Immunol."},{"key":"2025032406003175400_r11","doi-asserted-by":"crossref","first-page":"19863","DOI":"10.1073\/pnas.0810519105","article-title":"NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi","volume":"105","author":"Tupin","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032406003175400_r12","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1172\/JCI36264","article-title":"Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans","volume":"118","author":"De Santo","year":"2008","journal-title":"J. Clin. Invest."},{"key":"2025032406003175400_r13","doi-asserted-by":"crossref","first-page":"5590","DOI":"10.4049\/jimmunol.1002348","article-title":"Potential role of invariant NKT cells in the control of pulmonary inflammation and CD8+ T cell response during acute influenza A virus H3N2 pneumonia","volume":"186","author":"Paget","year":"2011","journal-title":"J. Immunol."},{"key":"2025032406003175400_r14","doi-asserted-by":"crossref","first-page":"e1000106","DOI":"10.1371\/journal.ppat.1000106","article-title":"NK cell-like behavior of Valpha14i NK T cells during MCMV infection","volume":"4","author":"Wesley","year":"2008","journal-title":"PLoS Pathog."},{"key":"2025032406003175400_r15","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature03407","article-title":"Recognition of bacterial glycosphingolipids by natural killer T cells","volume":"434","author":"Kinjo","year":"2005","journal-title":"Nature"},{"key":"2025032406003175400_r16","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ni1380","article-title":"Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria","volume":"7","author":"Kinjo","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025032406003175400_r17","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/ni.2096","article-title":"Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria","volume":"12","author":"Kinjo","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025032406003175400_r18","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1084\/jem.20102555","article-title":"Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection","volume":"208","author":"Brigl","year":"2011","journal-title":"J. Exp. Med."},{"key":"2025032406003175400_r19","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.immuni.2007.08.017","article-title":"Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids","volume":"27","author":"Paget","year":"2007","journal-title":"Immunity"},{"key":"2025032406003175400_r20","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nature03408","article-title":"Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections","volume":"434","author":"Mattner","year":"2005","journal-title":"Nature"},{"key":"2025032406003175400_r21","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/ni1002","article-title":"Mechanism of CD1d-restricted natural killer T cell activation during microbial infection","volume":"4","author":"Brigl","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025032406003175400_r22","doi-asserted-by":"crossref","first-page":"20490","DOI":"10.1073\/pnas.0710145104","article-title":"Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation","volume":"104","author":"Salio","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032406003175400_r23","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.chom.2011.09.011","article-title":"Innate recognition of cell wall \u03b2-glucans drives invariant natural killer T cell responses against fungi","volume":"10","author":"Cohen","year":"2011","journal-title":"Cell Host Microbe"},{"key":"2025032406003175400_r24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.immuni.2010.08.003","article-title":"Lysosomal \u03b1-galactosidase controls the generation of self lipid antigens for natural killer T cells","volume":"33","author":"Darmoise","year":"2010","journal-title":"Immunity"},{"key":"2025032406003175400_r25","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/ni.2143","article-title":"Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals","volume":"12","author":"Brennan","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025032406003175400_r26","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.4049\/jimmunol.178.5.2706","article-title":"Invariant NKT cells amplify the innate immune response to lipopolysaccharide","volume":"178","author":"Nagarajan","year":"2007","journal-title":"J. Immunol."},{"key":"2025032406003175400_r27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/1040841X.2012.706249","article-title":"Recognition of bacterial infection by innate immune sensors","volume":"39","author":"Kumar","year":"2013","journal-title":"Crit. Rev. Microbiol."},{"key":"2025032406003175400_r28","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.coi.2012.12.007","article-title":"Sensing of cell death by myeloid C-type lectin receptors","volume":"25","author":"Sancho","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"2025032406003175400_r29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/B978-0-12-410524-9.00004-9","article-title":"Intracellular pathogen detection by RIG-I-like receptors","volume":"117","author":"Dixit","year":"2013","journal-title":"Adv. Immunol."},{"key":"2025032406003175400_r30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1600-065X.2008.00731.x","article-title":"Pattern recognition receptors and control of adaptive immunity","volume":"227","author":"Palm","year":"2009","journal-title":"Immunol. Rev."},{"key":"2025032406003175400_r31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.smim.2012.01.001","article-title":"Examining host-microbial interactions through the lens of NOD: From plants to mammals","volume":"24","author":"Robertson","year":"2012","journal-title":"Semin. Immunol."},{"key":"2025032406003175400_r32","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3389\/fimmu.2012.00328","article-title":"NOD1 and NOD2 signaling in infection and inflammation","volume":"3","author":"Moreira","year":"2012","journal-title":"Front Immunol"},{"key":"2025032406003175400_r33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-065X.2008.00734.x","article-title":"Function of Nod-like receptors in microbial recognition and host defense","volume":"227","author":"Franchi","year":"2009","journal-title":"Immunol. Rev."},{"key":"2025032406003175400_r34","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1126\/science.1084677","article-title":"Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan","volume":"300","author":"Girardin","year":"2003","journal-title":"Science"},{"key":"2025032406003175400_r35","doi-asserted-by":"crossref","first-page":"8869","DOI":"10.1074\/jbc.C200651200","article-title":"Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection","volume":"278","author":"Girardin","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2025032406003175400_r36","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1074\/jbc.C200673200","article-title":"Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn\u2019s disease","volume":"278","author":"Inohara","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2025032406003175400_r37","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/ni945","article-title":"An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid","volume":"4","author":"Chamaillard","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025032406003175400_r38","doi-asserted-by":"crossref","first-page":"7925","DOI":"10.4049\/jimmunol.181.11.7925","article-title":"Nod2-dependent Th2 polarization of antigen-specific immunity","volume":"181","author":"Magalhaes","year":"2008","journal-title":"J. Immunol."},{"key":"2025032406003175400_r39","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.immuni.2007.03.009","article-title":"Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity","volume":"26","author":"Fritz","year":"2007","journal-title":"Immunity"},{"key":"2025032406003175400_r40","doi-asserted-by":"crossref","first-page":"14896","DOI":"10.1073\/pnas.1015063108","article-title":"Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation","volume":"108","author":"Magalhaes","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032406003175400_r41","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/hmg\/ddi087","article-title":"NOD1 variation, immunoglobulin E and asthma","volume":"14","author":"Hysi","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"2025032406003175400_r42","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/ng.952","article-title":"Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease","volume":"43","author":"Rivas","year":"2011","journal-title":"Nat. Genet."},{"key":"2025032406003175400_r43","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm.2391","article-title":"Identification of an innate T helper type 17 response to intestinal bacterial pathogens","volume":"17","author":"Geddes","year":"2011","journal-title":"Nat. Med."},{"key":"2025032406003175400_r44","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1128\/IAI.00759-10","article-title":"Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model","volume":"78","author":"Geddes","year":"2010","journal-title":"Infect. Immun."},{"key":"2025032406003175400_r45","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1128\/iai.32.2.748-758.1981","article-title":"Stimulation of nonspecific resistance to infection induced by 6-O-acyl muramyl dipeptide analogs in mice","volume":"32","author":"Matsumoto","year":"1981","journal-title":"Infect. Immun."},{"key":"2025032406003175400_r46","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/1753425912471691","article-title":"Identification of a synthetic muramyl peptide derivative with enhanced Nod2 stimulatory capacity","volume":"19","author":"Rubino","year":"2013","journal-title":"Innate Immun."},{"key":"2025032406003175400_r47","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1128\/iai.25.2.645-652.1979","article-title":"Mitogenic effects of bacterial cell walls, their fragments, and related synthetic compounds on thymocytes and splenocytes of guinea pigs","volume":"25","author":"Takada","year":"1979","journal-title":"Infect. Immun."},{"key":"2025032406003175400_r48","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1128\/iai.27.3.826-831.1980","article-title":"Immunostimulant activities of a lipophilic muramyl dipeptide derivative and of desmuramyl peptidolipid analogs","volume":"27","author":"Parant","year":"1980","journal-title":"Infect. Immun."},{"key":"2025032406003175400_r49","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1365-2567.2009.03130.x","article-title":"Rapid and reliable generation of invariant natural killer T-cell lines in vitro","volume":"128","author":"Chiba","year":"2009","journal-title":"Immunology"},{"key":"2025032406003175400_r50","doi-asserted-by":"crossref","first-page":"41702","DOI":"10.1074\/jbc.M307198200","article-title":"Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2","volume":"278","author":"Girardin","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2025032406003175400_r51","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.4049\/jimmunol.165.9.4917","article-title":"A subset of NKT cells that lacks the NK1.1 marker, expresses CD1d molecules, and autopresents the \u03b1-galactosylceramide antigen","volume":"165","author":"Hameg","year":"2000","journal-title":"J. Immunol."},{"key":"2025032406003175400_r52","doi-asserted-by":"crossref","first-page":"e45348","DOI":"10.1371\/journal.pone.0045348","article-title":"Direct engagement of TLR4 in invariant NKT cells regulates immune diseases by differential IL-4 and IFN-\u03b3 production in mice","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS ONE"},{"key":"2025032406003175400_r53","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.4049\/jimmunol.180.6.4082","article-title":"Activation of human NK cells by the bacterial pathogen-associated molecular pattern muramyl dipeptide","volume":"180","author":"Athi\u00e9-Morales","year":"2008","journal-title":"J. Immunol."},{"key":"2025032406003175400_r54","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1177\/1753425910372000","article-title":"Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors","volume":"17","author":"Qiu","year":"2011","journal-title":"Innate Immun"},{"key":"2025032406003175400_r55","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1053\/j.gastro.2012.04.017","article-title":"Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice","volume":"143","author":"Wingender","year":"2012","journal-title":"Gastroenterology"},{"key":"2025032406003175400_r56","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1126\/science.1219328","article-title":"Microbial exposure during early life has persistent effects on natural killer T cell function","volume":"336","author":"Olszak","year":"2012","journal-title":"Science"},{"key":"2025032406003175400_r57","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.tim.2005.08.008","article-title":"A mouse model for S. typhimurium-induced enterocolitis","volume":"13","author":"Hapfelmeier","year":"2005","journal-title":"Trends Microbiol."},{"key":"2025032406003175400_r58","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.smim.2009.10.006","article-title":"How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens","volume":"22","author":"Brigl","year":"2010","journal-title":"Semin. Immunol."},{"key":"2025032406003175400_r59","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1126\/science.1223490","article-title":"Interactions between the microbiota and the immune system","volume":"336","author":"Hooper","year":"2012","journal-title":"Science"},{"key":"2025032406003175400_r60","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/MOG.0b013e32835a68ea","article-title":"Nod-like receptors in intestinal host defense: controlling pathogens, the microbiota, or both?","volume":"29","author":"Robertson","year":"2013","journal-title":"Curr. Opin. Gastroenterol."},{"key":"2025032406003175400_r61","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1084\/jem.20031319","article-title":"Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+\/+ mice and can be reactivated by IFNgamma neutralization","volume":"199","author":"Monack","year":"2004","journal-title":"J. Exp. Med."},{"key":"2025032406003175400_r62","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1126\/science.8456301","article-title":"Immune response in mice that lack the interferon-gamma receptor","volume":"259","author":"Huang","year":"1993","journal-title":"Science"},{"key":"2025032406003175400_r63","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.4049\/jimmunol.163.9.4647","article-title":"Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells","volume":"163","author":"Carnaud","year":"1999","journal-title":"J. Immunol."},{"key":"2025032406003175400_r64","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.4049\/jimmunol.174.7.3864","article-title":"Cutting edge: IFN-gamma signaling to macrophages is required for optimal Valpha14i NK T\/NK cell cross-talk","volume":"174","author":"Wesley","year":"2005","journal-title":"J. Immunol."},{"key":"2025032406003175400_r65","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.4049\/jimmunol.1103582","article-title":"Role of \u03b3\u03b4 T cells in \u03b1-galactosylceramide-mediated immunity","volume":"188","author":"Paget","year":"2012","journal-title":"J. Immunol."},{"key":"2025032406003175400_r66","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.4049\/jimmunol.1100338","article-title":"C5a regulates NKT and NK cell functions in sepsis","volume":"187","author":"Fusakio","year":"2011","journal-title":"J. Immunol."},{"key":"2025032406003175400_r67","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.4049\/jimmunol.169.3.1426","article-title":"Critical role of NK cells rather than V alpha 14(+)NKT cells in lipopolysaccharide-induced lethal shock in mice","volume":"169","author":"Emoto","year":"2002","journal-title":"J. Immunol."},{"key":"2025032406003175400_r68","first-page":"88","article-title":"Activation of natural killer cells during microbial infections","volume":"2","author":"Horowitz","year":"2011","journal-title":"Front Immunol"},{"key":"2025032406003175400_r69","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1084\/jem.20010938","article-title":"Reciprocal activating interaction between natural killer cells and dendritic cells","volume":"195","author":"Gerosa","year":"2002","journal-title":"J. Exp. Med."},{"key":"2025032406003175400_r70","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fimmu.2013.00011","article-title":"Lipopolysaccharide induces IFN-\u03b3 production in human NK cells","volume":"4","author":"Kanevskiy","year":"2013","journal-title":"Front Immunol"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/191\/11\/5646\/62506154\/1301412.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/191\/11\/5646\/62506154\/1301412.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T12:03:50Z","timestamp":1742904230000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/191\/11\/5646\/7989559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,1]]},"references-count":70,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,12,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1301412","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,12]]},"published":{"date-parts":[[2013,12,1]]}}}