{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:24:49Z","timestamp":1767911089270,"version":"3.49.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Even though MHC class II is a dominant susceptibility factor for many diseases, culprit T cell epitopes presented by disease-associated MHC molecules remain largely elusive. T cells of celiac disease lesions recognize cereal gluten epitopes presented by the disease-associated HLA molecules DQ2.5, DQ2.2, or DQ8. Employing celiac disease and complex gluten Ag digests as a model, we tested the feasibility of using DQ2.5 and DQ2.2 as an affinity matrix for identification of disease-relevant T cell epitopes. Known gluten T cell epitope peptides were enriched by DQ2.5, whereas a different set of peptides was enriched by DQ2.2. Of 86 DQ2.2-enriched peptides, four core sequences dominated. One of these core sequences is a previously known epitope and two others are novel epitopes. The study provides insight into the selection of gluten epitopes by DQ2.2. Furthermore, the approach presented is relevant for epitope identification in other MHC class II\u2013associated disorders.<\/jats:p>","DOI":"10.4049\/jimmunol.1301466","type":"journal-article","created":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T03:29:33Z","timestamp":1411788573000},"page":"4497-4506","source":"Crossref","is-referenced-by-count":28,"title":["HLA-DQ Molecules as Affinity Matrix for Identification of Gluten T Cell Epitopes"],"prefix":"10.1093","volume":"193","author":[{"given":"Siri","family":"D\u00f8rum","sequence":"first","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, University of Oslo , 0424 Oslo ,","place":["Norway"]},{"name":"Proteomics Core Facility, Oslo University Hospital\u2013Rikshospitalet , 0027 Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bodd","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, Oslo University Hospital\u2013Rikshospitalet , 0424 Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars-Egil","family":"Fallang","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, University of Oslo , 0424 Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elin","family":"Bergseng","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, University of Oslo , 0424 Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asbj\u00f8rn","family":"Christophersen","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, University of Oslo , 0424 Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie K","family":"Johannesen","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, University of Oslo , 0424 Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo-Wang","family":"Qiao","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, University of Oslo , 0424 Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorunn","family":"Stamnaes","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, University of Oslo , 0424 Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo A","family":"de Souza","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, University of Oslo , 0424 Oslo ,","place":["Norway"]},{"name":"Proteomics Core Facility, Oslo University Hospital\u2013Rikshospitalet , 0027 Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludvig M","family":"Sollid","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, University of Oslo , 0424 Oslo ,","place":["Norway"]},{"name":"Centre for Immune Regulation, Department of Immunology, Oslo University Hospital\u2013Rikshospitalet , 0424 Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,11,1]]},"reference":[{"key":"2025030707424751700_r1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev.med.46.1.17","article-title":"Class II antigens and disease susceptibility","volume":"46","author":"Nepom","year":"1995","journal-title":"Annu. 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