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However, unlike ILCs, ID2 is not essential for thymic iNKT cell development. In this study, we demonstrated that ID2 and ID3 redundantly promoted iNKT cell lineage specification involving the induction of the signature transcription factor PLZF and that ID3 was critical for development of TBET-dependent NKT1 cells. In contrast, both ID2 and ID3 limited iNKT cell numbers by enforcing the postselection checkpoint in conventional thymocytes. Therefore, iNKT cells show both adaptive and innate-like requirements for ID proteins at distinct checkpoints during iNKT cell development.<\/jats:p>","DOI":"10.4049\/jimmunol.1301521","type":"journal-article","created":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T03:43:24Z","timestamp":1384573404000},"page":"5973-5983","source":"Crossref","is-referenced-by-count":62,"title":["Essential Functions for ID Proteins at Multiple Checkpoints in Invariant NKT Cell Development"],"prefix":"10.1093","volume":"191","author":[{"given":"Mihalis","family":"Verykokakis","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL 60637"},{"name":"Committee on Immunology, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Iavarone","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Columbia University Medical Center , New York, NY 10032"},{"name":"Department of Neurology, Columbia University Medical Center , New York, NY 10032"},{"name":"Department of Pathology, Columbia University Medical Center , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lasorella","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Columbia University Medical Center , New York, NY 10032"},{"name":"Department of Neurology, Columbia University Medical Center , New York, NY 10032"},{"name":"Department of Pathology, Columbia University Medical Center , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Sigvardsson","sequence":"additional","affiliation":[{"name":"Experimental Hematopoiesis Unit, Department of Clinical and Experimental Medicine, Faculty for Health Sciences, Link\u00f6ping University , 58183 Link\u00f6ping,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara L","family":"Kee","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL 60637"},{"name":"Committee on Immunology, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,12,15]]},"reference":[{"key":"2025032406072947800_r1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.immunol.25.022106.141711","article-title":"The biology of NKT cells","volume":"25","author":"Bendelac","year":"2007","journal-title":"Annu. 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