{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:51:29Z","timestamp":1760122289784,"version":"3.40.2"},"reference-count":92,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Resolution of Chlamydia genital tract infection is delayed in the absence of MyD88. In these studies, we first used bone marrow chimeras to demonstrate a requirement for MyD88 expression by hematopoietic cells in the presence of a wild-type epithelium. Using mixed bone marrow chimeras we then determined that MyD88 expression was specifically required in the adaptive immune compartment. Furthermore, adoptive transfer experiments revealed that CD4+ T cell expression of MyD88 was necessary for normal resolution of genital tract infection. This requirement was associated with a reduced ability of MyD88\u2212\/\u2212CD4+ T cells to accumulate in the draining lymph nodes and genital tract when exposed to the same inflammatory milieu as wild-type CD4+ T cells. We also demonstrated that the impaired infection control we observed in the absence of MyD88 could not be recapitulated by deficiencies in TLR or IL-1R signaling. In vitro, we detected an increased frequency of apoptotic MyD88\u2212\/\u2212CD4+ T cells upon activation in the absence of exogenous ligands for receptors upstream of MyD88. These data reveal an intrinsic requirement for MyD88 in CD4+ T cells during Chlamydia infection and indicate that the importance of MyD88 extends beyond innate immune responses by directly influencing adaptive immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.1301547","type":"journal-article","created":{"date-parts":[[2013,9,14]],"date-time":"2013-09-14T04:09:44Z","timestamp":1379131784000},"page":"4269-4279","source":"Crossref","is-referenced-by-count":15,"title":["CD4+ T Cell Expression of MyD88 Is Essential for Normal Resolution of <i>Chlamydia muridarum<\/i> Genital Tract Infection"],"prefix":"10.1093","volume":"191","author":[{"given":"Lauren C","family":"Frazer","sequence":"first","affiliation":[{"name":"Department of Immunology, University of Pittsburgh School of Medicine , Pittsburgh, PA 15201"},{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh of the University of Pittsburgh Medical Center , Pittsburgh, PA 15224"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne E","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh of the University of Pittsburgh Medical Center , Pittsburgh, PA 15224"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A","family":"Zurenski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh of the University of Pittsburgh Medical Center , Pittsburgh, PA 15224"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Mintus","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh of the University of Pittsburgh Medical Center , Pittsburgh, PA 15224"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy E","family":"Tomasak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh of the University of Pittsburgh Medical Center , Pittsburgh, PA 15224"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Prantner","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma M","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh of the University of Pittsburgh Medical Center , Pittsburgh, PA 15224"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toni","family":"Darville","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Pittsburgh School of Medicine , Pittsburgh, PA 15201"},{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh of the University of Pittsburgh Medical Center , Pittsburgh, PA 15224"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"2025032405465174600_r1","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1086\/652395","article-title":"Risk of sequelae after Chlamydia trachomatis genital infection in women","volume":"201","author":"Haggerty","year":"2010","journal-title":"J. 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