{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:39:52Z","timestamp":1779187192891,"version":"3.51.4"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To study regulatory T (Treg) cell control of chronic autoimmunity in a lymphoreplete host, we created and characterized a new model of autoimmune lung inflammation that targets the medium and small airways. We generated transgenic mice that express a chimeric membrane protein consisting of hen egg lysozyme and a hemoglobin epitope tag under the control of the Clara cell secretory protein promoter, which largely limited transgene expression to the respiratory bronchioles. When Clara cell secretory protein\u2013membrane hen egg lysozyme\/hemoglobin transgenic mice were crossed to N3.L2 TCR transgenic mice that recognize the hemoglobin epitope, the bigenic progeny developed dense, pseudo-follicular lymphocytic peribronchiolar infiltrates that resembled the histological pattern of follicular bronchiolitis. Aggregates of activated IFN-\u03b3\u2013 and IL-17A\u2013secreting CD4+ T cells as well as B cells surrounded the airways. Lung pathology was similar in Ifng\u2212\/\u2212 and Il17a\u2212\/\u2212 mice, indicating that either cytokine is sufficient to establish chronic disease. A large number of Ag-specific Treg cells accumulated in the lesions, and Treg cell depletion in the affected mice led to an interstitial spread of the disease that ultimately proved fatal. Thus, Treg cells act to restrain autoimmune responses, resulting in an organized and controlled chronic pathological process rather than a progressive disease.<\/jats:p>","DOI":"10.4049\/jimmunol.1301576","type":"journal-article","created":{"date-parts":[[2013,10,26]],"date-time":"2013-10-26T03:38:56Z","timestamp":1382758736000},"page":"5460-5476","source":"Crossref","is-referenced-by-count":4,"title":["Chronic Follicular Bronchiolitis Requires Antigen-Specific Regulatory T Cell Control To Prevent Fatal Disease Progression"],"prefix":"10.1093","volume":"191","author":[{"given":"Erica G","family":"Schmitt","sequence":"first","affiliation":[{"name":"Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin , Milwaukee, WI 53226"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipica","family":"Haribhai","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin , Milwaukee, WI 53226"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan C","family":"Jeschke","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin , Milwaukee, WI 53226"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic O","family":"Co","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin , Milwaukee, WI 53226"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Ziegelbauer","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin , Milwaukee, WI 53226"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Yan","sequence":"additional","affiliation":[{"name":"Section of Quantitative Health Sciences, Department of Pediatrics, Medical College of Wisconsin , Milwaukee, WI 53226"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science , Chiba 278-0022,","place":["Japan"]},{"name":"Core Research for Evolutional Science and Technology, Japan Science and Technology Agency , Saitama 332-0012,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj K","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Alabama State University , Montgomery, AL 36101"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pippa","family":"Simpson","sequence":"additional","affiliation":[{"name":"Section of Quantitative Health Sciences, Department of Pediatrics, Medical College of Wisconsin , Milwaukee, WI 53226"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nita H","family":"Salzman","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Department of Pediatrics, Medical College of Wisconsin , Milwaukee, WI 53226"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calvin B","family":"Williams","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin , Milwaukee, WI 53226"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,12,1]]},"reference":[{"key":"2025032406011500600_r1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J. 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