{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:17:17Z","timestamp":1790371037382,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pneumocystis is an atypical fungal pathogen that causes severe, often fatal pneumonia in immunocompromised patients. Healthy humans and animals also encounter this pathogen, but they generate a protective CD4+ T cell\u2013dependent immune response that clears the pathogen with little evidence of disease. Pneumocystis organisms attach tightly to respiratory epithelial cells, and in vitro studies have demonstrated that this interaction triggers NF-\u03baB\u2013dependent epithelial cell responses. However, the contribution of respiratory epithelial cells to the normal host response to Pneumocystis remains unknown. I\u03baB kinase 2 (IKK2) is the upstream kinase that is critical for inducible NF-\u03baB activation. To determine whether IKK2-dependent lung epithelial cell (LEC) responses contribute to the anti-Pneumocystis immune response in vivo, transgenic mice with LEC-specific deletion of IKK2 (IKK2\u0394LEC) were generated. Compared to wild-type mice, IKK2\u0394LEC mice exhibited a delayed onset of Th17 and B cell responses in the lung and delayed fungal clearance. Importantly, delayed Pneumocystis clearance in IKK2\u0394LEC mice was associated with an exacerbated immune response, impaired pulmonary function, and altered lung histology. These data demonstrate that IKK2-dependent LEC responses are important regulators of pulmonary adaptive immune responses and are required for optimal host defense against Pneumocystis infection. LECs likely set the threshold for initiation of the pulmonary immune response and serve to prevent exacerbated lung inflammation by promoting the rapid control of respiratory fungal infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1301679","type":"journal-article","created":{"date-parts":[[2013,9,28]],"date-time":"2013-09-28T05:03:48Z","timestamp":1380344628000},"page":"4720-4730","source":"Crossref","is-referenced-by-count":38,"title":["Selective Ablation of Lung Epithelial IKK2 Impairs Pulmonary Th17 Responses and Delays the Clearance of <i>Pneumocystis<\/i>"],"prefix":"10.1093","volume":"191","author":[{"given":"Nelissa","family":"Perez-Nazario","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester , Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Rangel-Moreno","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center , Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"O\u2019Reilly","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Rochester Medical Center , Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manolis","family":"Pasparakis","sequence":"additional","affiliation":[{"name":"Institute of Genetics, University of Cologne , D-50674 Cologne,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Gigliotti","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester , Rochester, NY 14642"},{"name":"Division of Infectious Diseases, Department of Pediatrics, University of Rochester Medical Center , Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry W","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester , Rochester, NY 14642"},{"name":"Division of Infectious Diseases, Department of Pediatrics, University of Rochester Medical Center , Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"2025032405523059700_r1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/infdis\/168.1.191","article-title":"Further evidence of host species-specific variation in antigens of Pneumocystis carinii using the polymerase chain reaction","volume":"168","author":"Gigliotti","year":"1993","journal-title":"J. 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