{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T07:42:01Z","timestamp":1772696521148,"version":"3.50.1"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The transcriptional repressor B lymphocyte\u2013induced maturation protein 1 (BLIMP1) is a master regulator of B and T cell differentiation. To examine the role of BLIMP1 in innate immunity, we used a conditional knockout (CKO) of Blimp1 in myeloid cells and found that Blimp1 CKO mice were protected from lethal infection induced by Listeria monocytogenes. Transcriptome analysis of Blimp1 CKO macrophages identified the murine chemokine (C-C motif) ligand 8, CCL8, as a direct target of Blimp1-mediated transcriptional repression in these cells. BLIMP1-deficient macrophages expressed elevated levels of Ccl8, and consequently Blimp1 CKO mice had higher levels of circulating CCL8, resulting in increased neutrophils in the peripheral blood, promoting a more aggressive antibacterial response. Mice lacking the Ccl8 gene were more susceptible to L. monocytogenes infection than were wild-type mice. Although CCL8 failed to recruit neutrophils directly, it was chemotactic for \u03b3\/\u03b4 T cells, and CCL8-responsive \u03b3\/\u03b4 T cells were enriched for IL-17F. Finally, CCL8-mediated enhanced clearance of L. monocytogenes was dependent on \u03b3\/\u03b4 T cells. Collectively, these data reveal an important role for BLIMP1 in modulating host defenses by suppressing expression of the chemokine CCL8.<\/jats:p>","DOI":"10.4049\/jimmunol.1301799","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T05:20:55Z","timestamp":1391059255000},"page":"2291-2304","source":"Crossref","is-referenced-by-count":32,"title":["The Transcriptional Repressor BLIMP1 Curbs Host Defenses by Suppressing Expression of the Chemokine CCL8"],"prefix":"10.1093","volume":"192","author":[{"given":"Martina","family":"Severa","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School , Worcester, MA 01605"},{"name":"Dipartimento di Malattie Infettive, Parassitarie ed Immuno-Mediata Malattie, Istituto Superiore di Sanit\u00e0 , 299-00161 Rome,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina A","family":"Islam","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02482"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen N","family":"Waggoner","sequence":"additional","affiliation":[{"name":"Department of Pathology and Program in Immunology and Virology, University of Massachusetts Medical School , Worcester, MA 01655"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaozhao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy D","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02482"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glennice","family":"Ryan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Kurt-Jones","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel","family":"Charo","sequence":"additional","affiliation":[{"name":"Gladstone Institute of Cardiovascular Disease, University of California , San Francisco, San Francisco CA 94158"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R","family":"Caffrey","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor L","family":"Boyartchuk","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Centre of Molecular Inflammation Research, Norwegian University of Science and Technology , 7489 Trondheim,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D","family":"Luster","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02482"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine A","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School , Worcester, MA 01605"},{"name":"Department of Cancer Research and Molecular Medicine, Centre of Molecular Inflammation Research, Norwegian University of Science and Technology , 7489 Trondheim,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,3,1]]},"reference":[{"key":"2025032404171356900_r1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00427-005-0044-5","article-title":"A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo","volume":"216","author":"Ng","year":"2006","journal-title":"Dev. Genes Evol."},{"key":"2025032404171356900_r2","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.cub.2004.09.046","article-title":"Blimp-1 specifies neural crest and sensory neuron progenitors in the zebrafish embryo","volume":"14","author":"Roy","year":"2004","journal-title":"Curr. Biol."},{"key":"2025032404171356900_r3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/ng1280","article-title":"The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling","volume":"36","author":"Baxendale","year":"2004","journal-title":"Nat. Genet."},{"key":"2025032404171356900_r4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1101\/gad.13.1.125","article-title":"PRDI-BF1\/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins","volume":"13","author":"Ren","year":"1999","journal-title":"Genes Dev."},{"key":"2025032404171356900_r5","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1101\/gad.5.5.868","article-title":"Identification and characterization of a novel repressor of beta-interferon gene expression","volume":"5","author":"Keller","year":"1991","journal-title":"Genes Dev."},{"key":"2025032404171356900_r6","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S1074-7613(03)00267-X","article-title":"Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells","volume":"19","author":"Shapiro-Shelef","year":"2003","journal-title":"Immunity"},{"key":"2025032404171356900_r7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/0-387-46530-8_2","article-title":"Multiple roles for Blimp-1 in B and T lymphocytes","volume":"596","author":"Savitsky","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"2025032404171356900_r8","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1084\/jem.20051611","article-title":"Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow","volume":"202","author":"Shapiro-Shelef","year":"2005","journal-title":"J. Exp. Med."},{"key":"2025032404171356900_r9","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/ni1321","article-title":"Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance","volume":"7","author":"Kallies","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025032404171356900_r10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ni1320","article-title":"Transcriptional repressor Blimp-1 regulates T cell homeostasis and function","volume":"7","author":"Martins","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025032404171356900_r11","doi-asserted-by":"crossref","first-page":"14988","DOI":"10.1073\/pnas.0707323104","article-title":"Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1","volume":"104","author":"Magn\u00fasd\u00f3ttir","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032404171356900_r12","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cell.2006.06.048","article-title":"Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland","volume":"126","author":"Horsley","year":"2006","journal-title":"Cell"},{"key":"2025032404171356900_r13","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1084\/jem.20110658","article-title":"Tolerogenic function of Blimp-1 in dendritic cells","volume":"208","author":"Kim","year":"2011","journal-title":"J. Exp. Med."},{"key":"2025032404171356900_r14","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nri1461","article-title":"Immune responses to Listeria monocytogenes","volume":"4","author":"Pamer","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"2025032404171356900_r15","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1034\/j.1600-0528.2002.017407.x","article-title":"Innate defenses in the liver during Listeria infection","volume":"174","author":"Cousens","year":"2000","journal-title":"Immunol. Rev."},{"key":"2025032404171356900_r16","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.micinf.2007.05.008","article-title":"Innate and adaptive immune responses to Listeria monocytogenes: a short overview","volume":"9","author":"Zenewicz","year":"2007","journal-title":"Microbes Infect."},{"key":"2025032404171356900_r17","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.4049\/jimmunol.169.7.3863","article-title":"Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice","volume":"169","author":"Seki","year":"2002","journal-title":"J. Immunol."},{"key":"2025032404171356900_r18","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.4049\/jimmunol.169.7.3869","article-title":"MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity","volume":"169","author":"Edelson","year":"2002","journal-title":"J. Immunol."},{"key":"2025032404171356900_r19","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.4049\/jimmunol.176.7.4337","article-title":"Distinct roles of TLR2 and the adaptor ASC in IL-1beta\/IL-18 secretion in response to Listeria monocytogenes","volume":"176","author":"Oz\u00f6ren","year":"2006","journal-title":"J. Immunol."},{"key":"2025032404171356900_r20","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/416194a","article-title":"RICK\/Rip2\/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems","volume":"416","author":"Kobayashi","year":"2002","journal-title":"Nature"},{"key":"2025032404171356900_r21","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"440","author":"Mariathasan","year":"2006","journal-title":"Nature"},{"key":"2025032404171356900_r22","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/ni.1864","article-title":"The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses","volume":"11","author":"Rathinam","year":"2010","journal-title":"Nat. Immunol."},{"key":"2025032404171356900_r23","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/eji.201040425","article-title":"Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome","volume":"40","author":"Kim","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"2025032404171356900_r24","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature08476","article-title":"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity","volume":"461","author":"Ishikawa","year":"2009","journal-title":"Nature"},{"key":"2025032404171356900_r25","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"Ishikawa","year":"2008","journal-title":"Nature"},{"key":"2025032404171356900_r26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/B978-0-12-394590-7.00002-6","article-title":"Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cell-mediated immunity","volume":"113","author":"Witte","year":"2012","journal-title":"Adv. Immunol."},{"key":"2025032404171356900_r27","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.4049\/jimmunol.1100088","article-title":"MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP","volume":"187","author":"Jin","year":"2011","journal-title":"J. Immunol."},{"key":"2025032404171356900_r28","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1128\/IAI.00999-10","article-title":"The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides","volume":"79","author":"Sauer","year":"2011","journal-title":"Infect. Immun."},{"key":"2025032404171356900_r29","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.4049\/jimmunol.173.12.7416","article-title":"IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism","volume":"173","author":"Stockinger","year":"2004","journal-title":"J. Immunol."},{"key":"2025032404171356900_r30","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.4049\/jimmunol.174.3.1602","article-title":"Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1","volume":"174","author":"O\u2019Connell","year":"2005","journal-title":"J. Immunol."},{"key":"2025032404171356900_r31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.immuni.2005.12.003","article-title":"Recognition of cytosolic DNA activates an IRF3-dependent innate immune response","volume":"24","author":"Stetson","year":"2006","journal-title":"Immunity"},{"key":"2025032404171356900_r32","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1126\/science.1189801","article-title":"c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response","volume":"328","author":"Woodward","year":"2010","journal-title":"Science"},{"key":"2025032404171356900_r33","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nature10429","article-title":"STING is a direct innate immune sensor of cyclic di-GMP","volume":"478","author":"Burdette","year":"2011","journal-title":"Nature"},{"key":"2025032404171356900_r34","doi-asserted-by":"crossref","first-page":"26188","DOI":"10.1074\/jbc.M604516200","article-title":"Toll-like receptor-dependent and -independent Viperin gene expression and counter-regulation by PRDI-binding factor-1\/BLIMP-1","volume":"281","author":"Severa","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2025032404171356900_r35","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"key":"2025032404171356900_r36","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1198\/016214504000000683","article-title":"A model-based background adjustment for oligonucleotide expression arrays","volume":"99","author":"Wu","year":"2004","journal-title":"J. Amer. Statist. Assoc."},{"key":"2025032404171356900_r37","doi-asserted-by":"crossref","first-page":"Article 3","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Statist. Appl. Genet. Mol. Biol."},{"key":"2025032404171356900_r38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Royal Statist. Soc. Series B (Methodological)"},{"key":"2025032404171356900_r39","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/bioinformatics\/btl567","article-title":"Using GOstats to test gene lists for GO term association","volume":"23","author":"Falcon","year":"2007","journal-title":"Bioinformatics"},{"key":"2025032404171356900_r40","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.1128\/MCB.01091-06","article-title":"Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc","volume":"26","author":"Sharma","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"2025032404171356900_r41","doi-asserted-by":"crossref","first-page":"5556","DOI":"10.4049\/jimmunol.173.9.5556","article-title":"B lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sites","volume":"173","author":"Kuo","year":"2004","journal-title":"J. Immunol."},{"key":"2025032404171356900_r42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/345175a0","article-title":"Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells","volume":"345","author":"Bielecki","year":"1990","journal-title":"Nature"},{"key":"2025032404171356900_r43","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.4049\/jimmunol.164.4.2064","article-title":"Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide","volume":"164","author":"Flo","year":"2000","journal-title":"J. Immunol."},{"key":"2025032404171356900_r44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic Res."},{"key":"2025032404171356900_r45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/77861","article-title":"BLIMP-1: trigger for differentiation of myeloid lineage","volume":"1","author":"Chang","year":"2000","journal-title":"Nat. Immunol."},{"key":"2025032404171356900_r46","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1093\/nar\/23.23.4878","article-title":"MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data","volume":"23","author":"Quandt","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"2025032404171356900_r47","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025032404171356900_r48","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1172\/JCI29919","article-title":"Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites","volume":"117","author":"Tsou","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2025032404171356900_r49","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1084\/jem.186.10.1757","article-title":"Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor","volume":"186","author":"Kurihara","year":"1997","journal-title":"J. Exp. Med."},{"key":"2025032404171356900_r50","doi-asserted-by":"crossref","first-page":"911","DOI":"10.4049\/jimmunol.1100588","article-title":"Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling","volume":"187","author":"Delano","year":"2011","journal-title":"J. Immunol."},{"key":"2025032404171356900_r51","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/ni.1984","article-title":"Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells","volume":"12","author":"Islam","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025032404171356900_r52","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.immuni.2012.05.008","article-title":"The chemokine superfamily revisited","volume":"36","author":"Zlotnik","year":"2012","journal-title":"Immunity"},{"key":"2025032404171356900_r53","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"Kolls","year":"2004","journal-title":"Immunity"},{"key":"2025032404171356900_r54","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.4049\/jimmunol.181.5.3456","article-title":"IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver","volume":"181","author":"Hamada","year":"2008","journal-title":"J. Immunol."},{"key":"2025032404171356900_r55","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.4049\/jimmunol.176.7.4331","article-title":"Homing and function of human skin gammadelta T cells and NK cells: relevance for tumor surveillance","volume":"176","author":"Ebert","year":"2006","journal-title":"J. Immunol."},{"key":"2025032404171356900_r56","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/intimm\/dxm128","article-title":"Involvement of CC chemokines in gammadelta T lymphocyte trafficking during allergic inflammation: the role of CCL2\/CCR2 pathway","volume":"20","author":"Penido","year":"2008","journal-title":"Int. Immunol."},{"key":"2025032404171356900_r57","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.jaci.2004.10.019","article-title":"IL-17 cytokine family","volume":"114","author":"Kawaguchi","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025032404171356900_r58","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2008.11.009","article-title":"Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses","volume":"30","author":"Ishigame","year":"2009","journal-title":"Immunity"},{"key":"2025032404171356900_r59","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.immuni.2009.08.001","article-title":"Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity","volume":"31","author":"Sutton","year":"2009","journal-title":"Immunity"},{"key":"2025032404171356900_r60","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0092-8674(94)90321-2","article-title":"Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells","volume":"77","author":"Turner","year":"1994","journal-title":"Cell"},{"key":"2025032404171356900_r61","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1126\/science.276.5312.596","article-title":"Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation","volume":"276","author":"Lin","year":"1997","journal-title":"Science"},{"key":"2025032404171356900_r62","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nri2800","article-title":"Innate IL-17-producing cells: the sentinels of the immune system","volume":"10","author":"Cua","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"2025032404171356900_r63","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/mi.2009.100","article-title":"Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa","volume":"2","author":"Khader","year":"2009","journal-title":"Mucosal Immunol."},{"key":"2025032404171356900_r64","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2567.2008.03017.x","article-title":"Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens","volume":"126","author":"Curtis","year":"2009","journal-title":"Immunology"},{"key":"2025032404171356900_r65","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1183\/09031936.04.00032904","article-title":"Neutrophils, interleukin-17A and lung disease","volume":"25","author":"Lind\u00e9n","year":"2005","journal-title":"Eur. Respir. J."},{"key":"2025032404171356900_r66","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1182\/blood.V98.12.3309","article-title":"Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice","volume":"98","author":"Forlow","year":"2001","journal-title":"Blood"},{"key":"2025032404171356900_r67","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1034\/j.1398-9995.2002.02164.x","article-title":"Neutrophilic airway inflammation and IL-17","volume":"57","author":"Lind\u00e9n","year":"2002","journal-title":"Allergy"},{"key":"2025032404171356900_r68","doi-asserted-by":"crossref","first-page":"5814","DOI":"10.4049\/jimmunol.165.10.5814","article-title":"IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells","volume":"165","author":"Witowski","year":"2000","journal-title":"J. Immunol."},{"key":"2025032404171356900_r69","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1189\/jlb.0204065","article-title":"Interleukin-17 regulates expression of the CXC chemokine LIX\/CXCL5 in osteoblasts: implications for inflammation and neutrophil recruitment","volume":"76","author":"Ruddy","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"2025032404171356900_r70","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0014-2999(03)01341-4","article-title":"Pharmacological modulation of interleukin-17-induced GCP-2-, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells","volume":"462","author":"Prause","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"2025032404171356900_r71","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-065X.2006.00477.x","article-title":"gammadelta T-cell receptors: functional correlations","volume":"215","author":"O\u2019Brien","year":"2007","journal-title":"Immunol. Rev."},{"key":"2025032404171356900_r72","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1600-065X.2006.00468.x","article-title":"Self\/non-self discrimination by human gammadelta T cells: simple solutions for a complex issue?","volume":"215","author":"Thedrez","year":"2007","journal-title":"Immunol. Rev."},{"key":"2025032404171356900_r73","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/intimm\/dxn069","article-title":"IL-17A is produced by Th17, gammadelta T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance","volume":"20","author":"Schulz","year":"2008","journal-title":"Int. Immunol."},{"key":"2025032404171356900_r74","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.4049\/jimmunol.178.6.3786","article-title":"IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection","volume":"178","author":"Umemura","year":"2007","journal-title":"J. Immunol."},{"key":"2025032404171356900_r75","doi-asserted-by":"crossref","first-page":"12304","DOI":"10.1128\/JVI.01269-12","article-title":"Type I interferon induction during influenza virus infection increases susceptibility to secondary Streptococcus pneumoniae infection by negative regulation of \u03b3\u03b4 T cells","volume":"86","author":"Li","year":"2012","journal-title":"J. Virol."},{"key":"2025032404171356900_r76","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1074-7613(03)00171-7","article-title":"TNF\/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection","volume":"19","author":"Serbina","year":"2003","journal-title":"Immunity"},{"key":"2025032404171356900_r77","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1002\/eji.201041363","article-title":"Specific depletion reveals a novel role for neutrophil-mediated protection in the liver during Listeria monocytogenes infection","volume":"41","author":"Carr","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"2025032404171356900_r78","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.4049\/jimmunol.1101721","article-title":"Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection","volume":"187","author":"Shi","year":"2011","journal-title":"J. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/192\/5\/2291\/62510880\/1301799.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/192\/5\/2291\/62510880\/1301799.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T06:47:15Z","timestamp":1742798835000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/192\/5\/2291\/7993544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,1]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,3,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1301799","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,3]]},"published":{"date-parts":[[2014,3,1]]}}}