{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:15:48Z","timestamp":1791900948503,"version":"4.3.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The process of lymphopoiesis begins in the bone marrow (BM) and requires multiple cellular intermediates. For T cell production, lymphoid progenitors exit the BM and home to the thymus where maturation and selection ensue. These processes are dependent on a number of factors, including chemokines and adhesion molecules. Although the \u03b22 integrin CD11a plays an important role in the migration of lymphocytes to lymph nodes, the role of CD11a in T cell development is largely undefined. Our studies now show that, in CD11a\u2212\/\u2212 mice, thymic cellularity was decreased and early T cell development was partially impaired. Remarkably, CD11a was critical for generation of common lymphoid progenitors (CLPs) and lymphoid-primed multipotent progenitors. However, in intact CD11a\u2212\/\u2212 mice, peripheral B and T cell subsets were only modestly altered, suggesting that compensatory mechanisms were operating. In contrast, competitive BM-reconstitution assays revealed an essential role for CD11a in the generation of thymocytes and mature T and B cells. This defect was linked to the requirement for CD11a in the development of CLPs. Furthermore, our results identified CLPs, and not lymphoid-primed multipotent progenitors, as the requisite CD11a-dependent precursor for lymphocyte development. Thus, these findings established a key role for CD11a in lymphopoiesis.<\/jats:p>","DOI":"10.4049\/jimmunol.1301820","type":"journal-article","created":{"date-parts":[[2014,8,9]],"date-time":"2014-08-09T06:47:01Z","timestamp":1407566821000},"page":"2863-2872","source":"Crossref","is-referenced-by-count":21,"title":["CD11a Is Essential for Normal Development of Hematopoietic Intermediates"],"prefix":"10.1093","volume":"193","author":[{"given":"Tina O","family":"Bose","sequence":"first","affiliation":[{"name":"Department of Immunology, Center for Integrated Immunology and Vaccine Research, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara L","family":"Colpitts","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center for Integrated Immunology and Vaccine Research, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quynh-Mai","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center for Integrated Immunology and Vaccine Research, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Puddington","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center for Integrated Immunology and Vaccine Research, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Lefran\u00e7ois","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center for Integrated Immunology and Vaccine Research, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"2025030707354071100_r1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1242\/dev.040998","article-title":"Embryonic origin of the adult hematopoietic system: advances and questions","volume":"138","author":"Medvinsky","year":"2011","journal-title":"Development"},{"key":"2025030707354071100_r2","doi-asserted-by":"crossref","first-page":"E75","DOI":"10.1371\/journal.pbio.0020075","article-title":"Circulation and chemotaxis of fetal hematopoietic stem cells","volume":"2","author":"Christensen","year":"2004","journal-title":"PLoS Biol."},{"key":"2025030707354071100_r3","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev.iy.10.040192.003551","article-title":"Lymphocyte development from stem cells","volume":"10","author":"Ikuta","year":"1992","journal-title":"Annu. 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